ID   A0A0R2RUZ3_9PROT        Unreviewed;       137 AA.
AC   A0A0R2RUZ3;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=Ferric uptake regulation protein {ECO:0000256|RuleBase:RU364037};
GN   Name=fur {ECO:0000256|RuleBase:RU364037};
GN   ORFNames=ABS03_04365 {ECO:0000313|EMBL:KRO64704.1};
OS   Pelagibacteraceae bacterium BACL5 MAG-120820-bin39.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Candidatus Pelagibacterales;
OC   Candidatus Pelagibacteraceae.
OX   NCBI_TaxID=1655605 {ECO:0000313|EMBL:KRO64704.1, ECO:0000313|Proteomes:UP000051468};
RN   [1] {ECO:0000313|EMBL:KRO64704.1, ECO:0000313|Proteomes:UP000051468}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BACL5 MAG-120820-bin39 {ECO:0000313|EMBL:KRO64704.1};
RA   Hugerth L.W., Larsson J., Alneberg J., Lindh M.V., Legrand C., Pinhassi J.,
RA   Andersson A.F.;
RT   "Metagenome-Assembled Genomes uncover a global brackish microbiome.";
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR602481-2};
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC         Evidence={ECO:0000256|PIRSR:PIRSR602481-2};
CC       Note=Binds 1 Mn(2+) or Fe(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR602481-2};
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|RuleBase:RU364037}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU364037}.
CC   -!- SIMILARITY: Belongs to the Fur family. {ECO:0000256|RuleBase:RU364037}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRO64704.1}.
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DR   EMBL; LIBV01000033; KRO64704.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0R2RUZ3; -.
DR   Proteomes; UP000051468; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd07153; Fur_like; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR002481; FUR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR33202:SF7; FERRIC UPTAKE REGULATION PROTEIN; 1.
DR   PANTHER; PTHR33202; ZINC UPTAKE REGULATION PROTEIN; 1.
DR   Pfam; PF01475; FUR; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|RuleBase:RU364037};
KW   DNA-binding {ECO:0000256|RuleBase:RU364037};
KW   Iron {ECO:0000256|PIRSR:PIRSR602481-2, ECO:0000256|RuleBase:RU364037};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR602481-2,
KW   ECO:0000256|RuleBase:RU364037}; Repressor {ECO:0000256|RuleBase:RU364037};
KW   Transcription {ECO:0000256|RuleBase:RU364037};
KW   Transcription regulation {ECO:0000256|RuleBase:RU364037};
KW   Zinc {ECO:0000256|RuleBase:RU364037}.
FT   BINDING         112
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR602481-2"
SQ   SEQUENCE   137 AA;  15917 MW;  32CCA84763C14297 CRC64;
     MTNNSIFLNK LRSSGLRPTK QRLKICEVLF DTEKTFHFTV NDLVKIIDEK MNEKISLATV
     YNTVHAFHKK GYLKEISINS DKSYFDTNTK IHHHFYDNNT KELTDISDDQ VEKVKINTSL
     PGKKITSVEV LVRVENK
//