ID A0A0R2S996_9ACTN Unreviewed; 337 AA.
AC A0A0R2S996;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Hemolysin {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=ABS00_06605 {ECO:0000313|EMBL:KRO71422.1};
OS Actinobacteria bacterium BACL2 MAG-120920-bin34.
OC Bacteria; Actinomycetota; Actinomycetes.
OX NCBI_TaxID=1655602 {ECO:0000313|EMBL:KRO71422.1, ECO:0000313|Proteomes:UP000051188};
RN [1] {ECO:0000313|EMBL:KRO71422.1, ECO:0000313|Proteomes:UP000051188}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BACL20 MAG-120920-bin34 {ECO:0000313|EMBL:KRO71422.1};
RA Hugerth L.W., Larsson J., Alneberg J., Lindh M.V., Legrand C., Pinhassi J.,
RA Andersson A.F.;
RT "Metagenome-Assembled Genomes uncover a global brackish microbiome.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRO71422.1}.
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DR EMBL; LIBS01000363; KRO71422.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0R2S996; -.
DR Proteomes; UP000051188; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR Gene3D; 3.30.465.10; -; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR002550; CNNM.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR044751; Ion_transp-like_CBS.
DR InterPro; IPR005170; Transptr-assoc_dom.
DR PANTHER; PTHR22777; HEMOLYSIN-RELATED; 1.
DR PANTHER; PTHR22777:SF17; UPF0053 INNER MEMBRANE PROTEIN YFJD; 1.
DR Pfam; PF00571; CBS; 1.
DR Pfam; PF01595; CNNM; 1.
DR Pfam; PF03471; CorC_HlyC; 1.
DR SMART; SM00116; CBS; 2.
DR SMART; SM01091; CorC_HlyC; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 1.
DR PROSITE; PS51371; CBS; 2.
DR PROSITE; PS51846; CNNM; 1.
PE 4: Predicted;
KW CBS domain {ECO:0000256|ARBA:ARBA00023122, ECO:0000256|PROSITE-
KW ProRule:PRU00703};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU01193}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU01193};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW ProRule:PRU01193}.
FT TRANSMEM 6..23
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 30..55
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..93
FT /note="CNNM transmembrane"
FT /evidence="ECO:0000259|PROSITE:PS51846"
FT DOMAIN 112..172
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 180..237
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KRO71422.1"
SQ SEQUENCE 337 AA; 37274 MW; 087783AA95848034 CRC64;
LIAVAAMVVL SYVVVGVGPR TLAKQNAVRW IIPACVVAVV MSKILGPLTS LLIAIGNAIT
PGKGFKSGPF ANEAELRDLV DQAHERGLVE ESEHEMIHSV FELGDTLVRE LMVPRIEMVW
IEGSKNLRQG LSLALRSGFT RIPVIGENLD EILGIAYVKD LARRTHEYRE AELTELVSDH
IRGATFVPET KTASELLKEM QRDQIHLAIV VDEYGGTAGL ITIEDILEEI VGEIADEYDD
DVEEFEWVTT SQVRVSARLH LEDLADKLEF ELSEDEKEDV DTIGGFVAKT LGRVPIPGST
VTLKGWVLTA ERPIGRRHRI ATFLVERPAD LVPDKEV
//
