ID A0A0R3NKX8_DROPS Unreviewed; 2856 AA.
AC A0A0R3NKX8;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 28-FEB-2018, entry version 18.
DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN Name=Dpse\GA24638 {ECO:0000313|EMBL:KRT01608.1};
GN ORFNames=Dpse_GA24638 {ECO:0000313|EMBL:KRT01608.1}, GA24638
GN {ECO:0000313|FlyBase:FBgn0246028};
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245 {ECO:0000313|EMBL:KRT01608.1, ECO:0000313|Proteomes:UP000001819};
RN [1] {ECO:0000313|EMBL:KRT01608.1, ECO:0000313|Proteomes:UP000001819}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94
RC {ECO:0000313|Proteomes:UP000001819};
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P.,
RA Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J.,
RA van Batenburg M.F., Howells S.L., Scherer S.E., Sodergren E.,
RA Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D.,
RA Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D.,
RA Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R.,
RA Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L.,
RA Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura:
RT chromosomal, gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
RN [2] {ECO:0000313|EMBL:KRT01608.1, ECO:0000313|Proteomes:UP000001819}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94
RC {ECO:0000313|Proteomes:UP000001819};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 Genomes Consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B.,
RA Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N.,
RA Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P.,
RA Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W.,
RA Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A.,
RA Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D.,
RA Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D.,
RA Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A.,
RA Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H.,
RA Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S.,
RA Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A.,
RA Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S.,
RA Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J.,
RA Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W.,
RA Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A.,
RA Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S.,
RA Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H.,
RA Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F.,
RA Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S.,
RA Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J.,
RA Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A.,
RA Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A.,
RA Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B.,
RA McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P.,
RA Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B.,
RA Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S.,
RA Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D.,
RA Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H.,
RA Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A.,
RA Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H.,
RA Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L.,
RA Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C.,
RA Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M.,
RA Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E.,
RA Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D.,
RA Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N.,
RA Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C.,
RA Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B.,
RA Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A.,
RA Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D.,
RA Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P.,
RA Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A.,
RA An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P.,
RA Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J.,
RA Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A.,
RA Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M.,
RA Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G.,
RA DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M.,
RA Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S.,
RA Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D.,
RA Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F.,
RA LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T.,
RA Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V.,
RA Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J.,
RA Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V.,
RA Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T.,
RA Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B.,
RA Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P.,
RA Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C.,
RA Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L.,
RA Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC -!- SUBCELLULAR LOCATION: Cell membrane
CC {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC {ECO:0000256|RuleBase:RU361132}.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; CM000071; KRT01608.1; -; Genomic_DNA.
DR RefSeq; XP_015039170.1; XM_015183684.1.
DR STRING; 7237.FBpp0277376; -.
DR EnsemblMetazoa; FBtr0370609; FBpp0332965; FBgn0246028.
DR GeneID; 6898122; -.
DR FlyBase; FBgn0246028; Dpse\GA24638.
DR Proteomes; UP000001819; Chromosome 3.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.120.350; -; 4.
DR InterPro; IPR031649; GPHH_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR Pfam; PF16905; GPHH; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR00170; NACHANNEL.
DR PROSITE; PS50096; IQ; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Complete proteome {ECO:0000313|Proteomes:UP000001819};
KW Ion channel {ECO:0000256|RuleBase:RU361132};
KW Ion transport {ECO:0000256|RuleBase:RU361132};
KW Membrane {ECO:0000256|SAAS:SAAS00085096};
KW Reference proteome {ECO:0000313|Proteomes:UP000001819};
KW Sodium {ECO:0000256|RuleBase:RU361132};
KW Sodium channel {ECO:0000256|RuleBase:RU361132};
KW Sodium transport {ECO:0000256|RuleBase:RU361132};
KW Transmembrane {ECO:0000256|SAAS:SAAS00084820};
KW Transmembrane helix {ECO:0000256|SAAS:SAAS00084701};
KW Transport {ECO:0000256|RuleBase:RU361132};
KW Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT DOMAIN 125 404 Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT DOMAIN 688 918 Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT DOMAIN 1751 2017 Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT DOMAIN 2069 2319 Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT DOMAIN 2325 2386 GPHH. {ECO:0000259|Pfam:PF16905}.
FT COILED 936 956 {ECO:0000256|SAM:Coils}.
FT COILED 1285 1305 {ECO:0000256|SAM:Coils}.
SQ SEQUENCE 2856 AA; 322775 MW; D84795503C00A53C CRC64;
MSDDQAGAND EKAVAKHQVV AYTQRSQVKH ENRHIQLVRE YGFHPRTKAS VEDGDVLPRK
FEPFPEDMYG KPLEEIDTFI YEETFCVVSK RFRKNYIHRF TGTKSLFLFH PWSPARRVCV
YIATNQFFDY CVMATILFNC IFLAMTETVE EAEYIFLAIY SIEMVIKIIA KGFLLNKYTY
LRNPWNWLDF VVITSGYATI GMEVGNLAGL RTFRVLRALK TVSIMPGLKT IINALLHSFR
QLAEVMTLTI FCLMVFALFA LQVYMGELRN KCVRHVPSEW SNVSHLDWHM WVNDTDNWLF
DDEEMPVLCG NLTGARHCPF GYMCICVGEN PNHENTNFDN FMWSMLTTFQ LITLDYWENV
YNMVLATCGP MSVIFFTVVV FFGSFYLINL MLAVVALSYE EEAEITNEER KKDLLDHRDD
STFSFDPSVL NVKKLNKNNK KRIDSRKGVL LASYSKKKTR RKKTKGGKET NGNGNGNGNG
SNGHENDANK SPSATPSPGP SPRHSATERP SALTRQAQKQ YKQIEQQQHH QHLLAKVPAA
ATPKNRISFQ EEPQKNPNML YPSDNKGQLI ASSRQTSSNS SGVNRESSQD DSGVVDDHEE
QDPANELGHV STVELALSPR EVRLIKCNGN IARIKNHNVY ALHQEFSSEV VVIDDLPDRN
CDRCVHCCAD YESWLQFQNC LYKVVRDPLF ELAITLCIVL NTAFLAMEHH GMSESFRNAL
DVGNKVFTSI FTFECIVKLM ALSKDFFLCG WNIFDLLIVT ASLLDIIFEL VDGLSVLRGL
RLLRVLKLAQ SWTTMKVLLS IIISTIGALG NLTLILVIVI YIFAVIGMQL FSKDYTAEKF
DPDPVPRWNF NDFFHSFMMI FRILCGEWIE PLWDCMRAEE EQGASTCFAI FLPTLVMGNF
MVLNLFLALL LNSFNSEELK SKKEEVGEES KLARSIERVR DLIRKKRQER KDRKERKFAE
KFQQIVLEAQ AQAHAQSQGQ AQGGMEMDKS NLLAETKFHR LSYQESMNRP VSGSDFGFQI
PLRDGLHTIV DGLEYDEASD VPEQIQLQDQ PLPPITDSLP PTYETAIMSA HSNNLTPFAL
AERRLQHQIS SGVSTQQNDS RDEATYTESI ELRLLGQYNS TDTDPYANDQ RSGSFNRGDS
FQDNSSRRYG SEEHDEAYLK YQKSLLTRSP SYRKSLDRLS QSSGHSQRSL LKSEEAEMRR
HSSGHSLNSI SIEQEELLSQ QGNLREELLN CEQKELFQFL QEDNEMPKSN LSYISSNLMR
SRRSSSQGHQ ESEALVEHSE FDNIIQSFEK ELEEIKRSTT SLERKLSTLS EPSPAADEAT
KAIMEHIAII TGASERTAAD EVVHPLNPYD SYDLSSVPRR SQSVSSAAQR QSVKIKRRSL
EKQRKIDEDF SISNEIRKIC DQIHAPFVAM EAMAVAATSQ GPGASQSPFT RRKIDPFTVQ
FDRFKRLSLI ERLEELPEEE KPISTLRIES EKMPRKFLNS DQLRLDSLSL KSTNSYENLL
IQKQKLVLPL STGVPATPPT SLKSSIEPPT LAQISSLKVT PTPTPPLAAL TEHQQHFHAT
SIQTAPSHGH GQRHTHGSGH RHGNGHSQAH PTAGQRRRPM EHPQSTLDKA ASFQSARTES
HSSGAADTSS ALALALAHTH KTEQSDQPEK AAQKPSAFTR LTEKPWHCLV SYVDDLTVGG
RRNSQGAYND PMTFPSYGQA KPPKVPDDCF PQKCYDHFYF RCPWFMSCMD TPSAKQWTRI
RTAVLTVVDT PAFEWFVLVL IFASSITLCF EDIYLDSNKT LKRVLYWTNF SFCLIFVVEM
ILKWLALGFS KYFTSFWTIL DFIIVFVSVF SLLIEENENL KVLRSLRTLR ALRPLRAISR
WQGMRIVVNA LMYAIPSIFN VLLVCLVFWL IFSIMGVQFF GGKFFKCVNE MGELLPITEV
NDKWDCIEQN YTWINSKITF DHVGMGYLAL LQVATFEGWM EVMADAVDAR GVDLQPQREA
NLYAYIYFVI FIVCGSFFTL NLFIGVIIDN FNMLKKKYEG GVLEMFLTES QKHYYTAMKK
LGRKKPQKVI KRPINHFLAM FYDLSNSRRF EIAIFVLIFL NMLTMGIEHY DQPHAVFFIL
EVSNAFFTTV FGLEAIVKIV GLRYHYFTVP WNVFDFLLVL ASIFGILMED IMIDLPISPT
LLRVVRVFRI GRILRLIKAA KGIRKLLFAL VVSLPALFNI GALLGLITFI YAILGMSLFG
HVKLQGALDD MVNFQTFGRS MQLLFRLMTS AGWNDVLESL MIQPPDCDPF FNRQTNGDCG
HPLLAITYFT SFIIISYMIV INMYIAIILE NFNQAHQEEE IGIVEDDLEM FYIRWSKYDP
HATQFIHFSQ LSDFIASLDP PLGISKPNNV ALVSFNLPIS KGNKIHCLDI LHALVKHVLG
HVEETDNFKQ LQEQMDVKFK KQFPTRKELE IVSSTRIWKR QEKAAKTIQT GWKDYLRRKN
EKERSNSGDS ATQTSSPGGW QSKLSALNFF HLQVSRRGTA CSSRASSRKS SRASDGSDLS
ELAGPWLNLP LMLVSGADDV VKDIKQQSDD MGKRISSCIS LNYESLLADM VTAVLRSDSQ
PSGLNYLAAI NPTTNTTTSA SVSVSASGAA SATATATAAS ASDSDRQQVV GGPVNSRKRA
SSFIRKKPPL ERGLSAQSAL RVNKNAFVSE GPAPEVIVTR PSPDQQTHPH MHALGLRPDN
ATLVHVLVHR ESEEYKEEDE GSLSSTGNGN GNGNGHDKPK PPQIRISTGS SESPMDTSLM
PTVQIMVDSP KEPPRGDFST ELAATSTAVT IGVEVDPSPI DVNVQGDTSQ VFYDYNPDKA
TGNEIVEIDT LDEDEEQTAA ERGIEAEALP AEDQQR
//
