ID   A0A0R3QL11_9BILA        Unreviewed;       883 AA.
AC   A0A0R3QL11;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   27-MAR-2024, entry version 36.
DE   RecName: Full=leucine--tRNA ligase {ECO:0000256|ARBA:ARBA00013164};
DE            EC=6.1.1.4 {ECO:0000256|ARBA:ARBA00013164};
DE   AltName: Full=Leucyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00030520};
GN   ORFNames=BTMF_LOCUS6413 {ECO:0000313|EMBL:VDO21712.1};
OS   Brugia timori.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX   NCBI_TaxID=42155 {ECO:0000313|Proteomes:UP000050602, ECO:0000313|WBParaSite:BTMF_0000836201-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:BTMF_0000836201-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDO21712.1, ECO:0000313|Proteomes:UP000280834}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC       {ECO:0000256|ARBA:ARBA00005594, ECO:0000256|RuleBase:RU363035}.
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DR   EMBL; UZAG01015589; VDO21712.1; -; Genomic_DNA.
DR   STRING; 42155.A0A0R3QL11; -.
DR   WBParaSite; BTMF_0000836201-mRNA-1; BTMF_0000836201-mRNA-1; BTMF_0000836201.
DR   Proteomes; UP000050602; Unplaced.
DR   Proteomes; UP000280834; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004823; F:leucine-tRNA ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006429; P:leucyl-tRNA aminoacylation; IEA:InterPro.
DR   CDD; cd00812; LeuRS_core; 1.
DR   Gene3D; 3.40.50.620; HUPs; 2.
DR   InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR   InterPro; IPR002300; aa-tRNA-synth_Ia.
DR   InterPro; IPR002302; Leu-tRNA-ligase.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR   PANTHER; PTHR43740:SF3; LEUCINE--TRNA LIGASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43740; LEUCYL-TRNA SYNTHETASE; 1.
DR   Pfam; PF00133; tRNA-synt_1; 2.
DR   PRINTS; PR00985; TRNASYNTHLEU.
DR   SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR   SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR   PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW   ECO:0000256|RuleBase:RU363035};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363035};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363035};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU363035};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW   ECO:0000256|RuleBase:RU363035};
KW   Reference proteome {ECO:0000313|Proteomes:UP000280834}.
FT   DOMAIN          51..241
FT                   /note="Aminoacyl-tRNA synthetase class Ia"
FT                   /evidence="ECO:0000259|Pfam:PF00133"
FT   DOMAIN          408..552
FT                   /note="Aminoacyl-tRNA synthetase class Ia"
FT                   /evidence="ECO:0000259|Pfam:PF00133"
SQ   SEQUENCE   883 AA;  101970 MW;  A380EAC45E8F517F CRC64;
     MESSFLLPKI RYHLAKFYSK ASASHIKTPM LIWPRKEYGI STKLFDLEKY WKEVAQIAPS
     IHFSRPKKYI LSMYPYPSGR LHMGHMRVYT ISDVLARYYR LNGYNVIHPI GWDAFGLPAE
     NAAREVGVDP AQWTANNIDV MRQQLLSTGI IFDWNREIST CSPDYYRWTQ WIFCRLFERG
     LVRRALTEVH WDPIDCTVLA AEQIDAEGRS WRSGAVAEKR KIKHWMIETP KYAKRMYVGL
     EKLAHWKEVA AIQANWIGKC DVWRFLLPLK ERNGTVLDEK FDLRIREPHH LATASVIFIQ
     FGHPLFSLAD EKEEIGVLKV TALNIITGKD MHIIYMNENA AKNRNGFILN ARLPCEADEF
     DKKVTESFGF STERCRFSLT NNDIIQIAEI FPFKFGDYGG YETSERLLDW VVSRQRKWGT
     PIPVLLSADD RCAAIVADDQ LPVIAAHYKY DEKIPCQRLP DGFGYLEKDT LDTFFDSSWY
     YLRFLDPKND IELVSEKKSI DMPVDVYVGG IEHAALHLFF ARFVSYFLHD IGVSSVQEPF
     DSLLPQGIVC SRTFKRSDSG KYLKEDDVVQ TGNGFIAKKD GCAVFTQFEK MSKSKHNGVD
     PLSVLKLKGI DLTRLQLLNE AAPREPINWG DTELKGLFKF MERTSDVISF YVEQHALSAS
     TLPEPLDIAR EEKYRTIYNF YVRNISMVIE VLHLHNTAID HLQSFVKFLK KSSAEAYRCS
     VQLERCVHAL VIMMQLFTPH LAAEYWAALR SVPALSGHRV WLDKEINEQP WPQVDPDAKI
     DFMINVGKLS CGRVEVPRLE IEHLSSEEVL QYAIDDVHSI FFQELASLGF RPISCKKLSR
     TGFYVLLEVK FNKVPAEETL IDILKQTRMQ RLKVKRARKK AEK
//