ID A0A0R3RYX8_9BILA Unreviewed; 652 AA.
AC A0A0R3RYX8;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=glutaminase {ECO:0000256|ARBA:ARBA00012918};
DE EC=3.5.1.2 {ECO:0000256|ARBA:ARBA00012918};
OS Elaeophora elaphi.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Elaeophora.
OX NCBI_TaxID=1147741 {ECO:0000313|Proteomes:UP000050640, ECO:0000313|WBParaSite:EEL_0000750301-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:EEL_0000750301-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + L-glutamine = L-glutamate + NH4(+);
CC Xref=Rhea:RHEA:15889, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:29985, ChEBI:CHEBI:58359; EC=3.5.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001062};
CC -!- SUBUNIT: Homotetramer. {ECO:0000256|ARBA:ARBA00011881}.
CC -!- SIMILARITY: Belongs to the glutaminase family.
CC {ECO:0000256|ARBA:ARBA00011076}.
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DR AlphaFoldDB; A0A0R3RYX8; -.
DR STRING; 1147741.A0A0R3RYX8; -.
DR WBParaSite; EEL_0000750301-mRNA-1; EEL_0000750301-mRNA-1; EEL_0000750301.
DR Proteomes; UP000050640; Unplaced.
DR GO; GO:0004359; F:glutaminase activity; IEA:UniProtKB-EC.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:InterPro.
DR Gene3D; 1.10.238.210; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR015868; Glutaminase.
DR InterPro; IPR041541; Glutaminase_EF-hand.
DR PANTHER; PTHR12544; GLUTAMINASE; 1.
DR PANTHER; PTHR12544:SF29; GLUTAMINASE; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF17959; EF-hand_14; 1.
DR Pfam; PF04960; Glutaminase; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 78..167
FT /note="Glutaminase EF-hand"
FT /evidence="ECO:0000259|Pfam:PF17959"
FT REPEAT 484..506
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 602..641
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 652 AA; 73113 MW; A88182FABBDAE350 CRC64;
MYSGTPINAQ RTKYRLAEHQ RRKNFKEMES DEYKCASAAV DNVSKILKNS RKSSVTRLLN
DTAKGLKHVY QLSHPSQEDL TYDLFKCSKK PEEASLGKLL SVLRSFGIRE DDPRLKHTIE
KMHEYELQIE DDCDTRHCLL TKEQFKECIR PSINLIAQTL RNDLIIPCWG EFTAKIKEIF
DECASIHEGK VADYIPQLAR VDPKKWGLSI CTIDGQRVSY GDARVPFCFQ SISKAFNYAI
VASDMGADFV HNYVGHEPSG RLFNEICLDC NGKPHNPLIN AGAIVVTSLL KMGHKMADRY
DFVLTQYKKL AGGGYIGFNN ATFLSERDTA DRNYALSYYM KENNCFPGTV SLRDELDFYF
QLCSLETTCE SAAVGLPAKS GVSGAMVVVV PNLMGICIWS PPLDKMSNSV RGVSFCKKMI
DTFNFHNYDS LLHADTKKID PRKRGIPNES ELILEMMFAT KKGDIDDVRR MFLGGVDLNM
SDYDGRTPLH LAASEGQTLM VDFFLDIAHV NPLVRDRWNR TAYDDALSFG FIKIAEKIKS
AMDKISGGFV PITIPPDKAR QLLPENGDVL INLPEETNEW EKELRIVVDR LSYFDRSNSD
CVTSPSSVEN GDGKTDFLEK SPDENGGSSA LDAESITDGS GGQIDLSIKF SS
//
