ID A0A0R3WE01_TAEAS Unreviewed; 695 AA.
AC A0A0R3WE01;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 2.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 11 {ECO:0000256|RuleBase:RU364147};
DE AltName: Full=Mediator complex subunit 11 {ECO:0000256|RuleBase:RU364147};
GN Name=MED11 {ECO:0000256|RuleBase:RU364147};
GN ORFNames=TASK_LOCUS9022 {ECO:0000313|EMBL:VDK41527.1};
OS Taenia asiatica (Asian tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Taenia.
OX NCBI_TaxID=60517 {ECO:0000313|Proteomes:UP000046400, ECO:0000313|WBParaSite:TASK_0000902101-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:TASK_0000902101-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDK41527.1, ECO:0000313|Proteomes:UP000282613}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional pre-initiation complex with RNA polymerase II
CC and the general transcription factors. {ECO:0000256|RuleBase:RU364147}.
CC -!- SUBUNIT: Component of the Mediator complex.
CC {ECO:0000256|RuleBase:RU364147}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364147}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 11 family.
CC {ECO:0000256|ARBA:ARBA00008186, ECO:0000256|RuleBase:RU364147}.
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DR EMBL; UYRS01018961; VDK41527.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0R3WE01; -.
DR STRING; 60517.A0A0R3WE01; -.
DR WBParaSite; TASK_0000902101-mRNA-1; TASK_0000902101-mRNA-1; TASK_0000902101.
DR Proteomes; UP000046400; Unplaced.
DR Proteomes; UP000282613; Unassembled WGS sequence.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.287.3490; -; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR019404; Mediator_Med11.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR45808; RHO GTPASE-ACTIVATING PROTEIN 68F; 1.
DR PANTHER; PTHR45808:SF2; RHO GTPASE-ACTIVATING PROTEIN 68F; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF10280; Med11; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|RuleBase:RU364147};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364147};
KW Reference proteome {ECO:0000313|Proteomes:UP000282613};
KW Transcription {ECO:0000256|RuleBase:RU364147};
KW Transcription regulation {ECO:0000256|RuleBase:RU364147};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 388..410
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 482..692
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
SQ SEQUENCE 695 AA; 79399 MW; 511193310541202C CRC64;
MSYKDSGQSP PNLKERLQKL DEIESKVMQI MQSAGGTLGE LSRDLPSQKQ IEMYARNFRD
AVRDVELELI SQLNYLSQVL AGLPYEKNAY KETIDLTIAA ERLKNSLHAD SSQDTLPVGK
VTCDLPLKTE AVESDPAVTS TVNESDLSYS DSVSEKTAVP TSAKPHWRFC SVQTVNSPHF
FESETPQTSV HEFEIPEFEF DDEIPDLEGD LDDDDFEGPM TPEEFIDEDF ERELGWYEKA
CANFRCSLPC RPWELSIQEV IDSEFRDISR LGIIQVGVTD HDGRSVIAYV TKTLEQYASS
EYTLVYFHWG LTSRNKPSFP WLARAYQTFD RSTLLSHIGK LKQLPPVDLF VLFSFKKNLK
SLIIVYPTRT VCVLWNLFSA FIRQGFLTGI FVIEMFMIGS VITLCTQFSA KMKKKLHYVK
NLHELENYVP LCRLNLPLRI RDYDSKIGLF GVSLSIDPAA VSVIGDHDFN DTPYNDYQQF
GVSLEYIKAN NGGRKLPIVV EDTITYLRGY GLDTIGLFVK PVHLMALRDA QSMYNRGEYV
DLCEINDPHL AAHLLKSFLS ELKEPLLTFD LYESILKSCS QSPRQRVISI RRLLTVHLPR
DNYDILYYIF KFLTEVSWRF SWQSLMASTI LLLPIKVIEH SVKNMVTAVS LSVAMAPCLI
RSRQDFVTPS QRVQNLVTSF TQLCITHFES VFIRA
//
