ID A0A0R3WXT0_HYDTA Unreviewed; 210 AA.
AC A0A0R3WXT0;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=FACT complex subunit {ECO:0000256|RuleBase:RU367052};
OS Hydatigena taeniaeformis (Feline tapeworm) (Taenia taeniaeformis).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Hydatigera.
OX NCBI_TaxID=6205 {ECO:0000313|Proteomes:UP000046396, ECO:0000313|WBParaSite:TTAC_0000557001-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:TTAC_0000557001-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
CC -!- FUNCTION: Component of the FACT complex, a general chromatin factor
CC that acts to reorganize nucleosomes. The FACT complex is involved in
CC multiple processes that require DNA as a template such as mRNA
CC elongation, DNA replication and DNA repair. During transcription
CC elongation the FACT complex acts as a histone chaperone that both
CC destabilizes and restores nucleosomal structure. It facilitates the
CC passage of RNA polymerase II and transcription by promoting the
CC dissociation of one histone H2A-H2B dimer from the nucleosome, then
CC subsequently promotes the reestablishment of the nucleosome following
CC the passage of RNA polymerase II. {ECO:0000256|RuleBase:RU367052}.
CC -!- SUBUNIT: Component of the FACT complex.
CC {ECO:0000256|RuleBase:RU367052}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU367052}.
CC Chromosome {ECO:0000256|RuleBase:RU367052}.
CC -!- SIMILARITY: Belongs to the peptidase M24 family. SPT16 subfamily.
CC {ECO:0000256|RuleBase:RU367052}.
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DR AlphaFoldDB; A0A0R3WXT0; -.
DR STRING; 6205.A0A0R3WXT0; -.
DR WBParaSite; TTAC_0000557001-mRNA-1; TTAC_0000557001-mRNA-1; TTAC_0000557001.
DR Proteomes; UP000046396; Unplaced.
DR GO; GO:0035101; C:FACT complex; IEA:UniProtKB-UniRule.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 2.30.29.150; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR013719; RTT106/SPT16-like_middle_dom.
DR InterPro; IPR040258; Spt16.
DR PANTHER; PTHR13980; CDC68 RELATED; 1.
DR PANTHER; PTHR13980:SF15; FACT COMPLEX SUBUNIT SPT16; 1.
DR Pfam; PF08512; Rttp106-like_middle; 1.
DR SMART; SM01287; Rtt106; 1.
PE 3: Inferred from homology;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454, ECO:0000256|RuleBase:RU367052};
KW DNA damage {ECO:0000256|RuleBase:RU367052};
KW DNA repair {ECO:0000256|RuleBase:RU367052};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|RuleBase:RU367052}; Nucleus {ECO:0000256|RuleBase:RU367052};
KW Transcription {ECO:0000256|RuleBase:RU367052};
KW Transcription regulation {ECO:0000256|RuleBase:RU367052}.
FT DOMAIN 129..210
FT /note="Histone chaperone RTT106/FACT complex subunit SPT16-
FT like middle"
FT /evidence="ECO:0000259|SMART:SM01287"
SQ SEQUENCE 210 AA; 24764 MW; 3CA62FAD1A09003A CRC64;
LEAHSNGFRF TSIRGDKVDI LYNNIKHAFY QPCDGEMIIL LHFNLKNAIM YGKKKQDNIQ
FYTEVGELTT DLGKSHGRMY DRDDLEAEQR EREMREQIKT AFKTFVERVE NLARRYNLEF
EVPFRDLGFY GCPLRTTVFM MPTSSCLVSL SEWPPFVITL EEVELVMFER VSLSIKTFDM
IFVFKDYRIK PAMITSIPSN SLDHVKEWIL
//
