ID A0A0R4I9C5_DANRE Unreviewed; 448 AA.
AC A0A0R4I9C5;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Riboflavin transporter {ECO:0000256|RuleBase:RU368035};
GN Name=slc52a3 {ECO:0000313|Ensembl:ENSDARP00000062715,
GN ECO:0000313|ZFIN:ZDB-GENE-060421-4490};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000062715};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000062715}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000062715};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000062715}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000062715};
RG Ensembl;
RL Submitted (NOV-2015) to UniProtKB.
CC -!- FUNCTION: Plasma membrane transporter mediating the uptake by cells of
CC the water soluble vitamin B2/riboflavin that plays a key role in
CC biochemical oxidation-reduction reactions of the carbohydrate, lipid,
CC and amino acid metabolism. {ECO:0000256|RuleBase:RU368035}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=riboflavin(in) = riboflavin(out); Xref=Rhea:RHEA:35015,
CC ChEBI:CHEBI:57986; Evidence={ECO:0000256|ARBA:ARBA00000215,
CC ECO:0000256|RuleBase:RU368035};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU368035}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU368035}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the riboflavin transporter family.
CC {ECO:0000256|ARBA:ARBA00006366, ECO:0000256|RuleBase:RU368035}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CABZ01087205; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01087206; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01087207; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001035447.1; NM_001040357.1.
DR Ensembl; ENSDART00000062716.7; ENSDARP00000062715.4; ENSDARG00000042737.7.
DR Ensembl; ENSDART00000189724.1; ENSDARP00000145645.1; ENSDARG00000042737.7.
DR GeneID; 678609; -.
DR KEGG; dre:678609; -.
DR AGR; ZFIN:ZDB-GENE-060421-4490; -.
DR CTD; 113278; -.
DR ZFIN; ZDB-GENE-060421-4490; slc52a3.
DR OMA; CGAAAQM; -.
DR OrthoDB; 5477759at2759; -.
DR Bgee; ENSDARG00000042737; Expressed in intestine and 10 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032217; F:riboflavin transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR InterPro; IPR009357; Riboflavin_transptr.
DR PANTHER; PTHR12929; SOLUTE CARRIER FAMILY 52; 1.
DR PANTHER; PTHR12929:SF4; SOLUTE CARRIER FAMILY 52, RIBOFLAVIN TRANSPORTER, MEMBER 3; 1.
DR Pfam; PF06237; SLC52_ribofla_tr; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|RuleBase:RU368035};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU368035};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU368035};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU368035}; Transport {ECO:0000256|RuleBase:RU368035}.
FT TRANSMEM 42..61
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368035"
FT TRANSMEM 73..95
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368035"
FT TRANSMEM 107..129
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368035"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368035"
FT TRANSMEM 199..218
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368035"
FT TRANSMEM 280..300
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368035"
FT TRANSMEM 312..334
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368035"
FT TRANSMEM 339..357
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368035"
FT TRANSMEM 377..400
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368035"
FT TRANSMEM 407..430
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368035"
SQ SEQUENCE 448 AA; 48669 MW; B5AEB30ABCB13153 CRC64;
MPLYIHALAC AFGLGSWVSI NGLWVELPLI VNVLPEGWDL PSYLTVIIQF ANLGPLLVTL
AHKFCPGRLR ENLAIYAVLS IGVVACILLA VFWNYTTVIF GQPRSTAFFI LTFFLALVDC
TSSVTFLPFM MQLPAKYITT YFIGEGLSGL VPGLVALAQG VGMSKCVNVT NVSDNVTDPG
PPTFIVETQY LPPNFSTEIF FSFLAVMTTI SLGAFLILNR LPRTFELSTE NLVSDSDAVA
TVCRGLEGPM DPKTNCPEEV EQKQNEVLLP KPQHSSYQLA FIYVMVLWVN SATNGLLPSV
QTFSCMPYGN MAYHLSAALS AVANPVACII AMFFPKRSLV FLGILCLLGS TFGGYNMAMA
AMSPCPLLQD TPLGDAIIVL SWVFFTGLLS YVKVMVGVIL RDRSHSALVW CGAAVQTGSL
LGSIIMFPLV NVYHLFKSGD ICNTNCPL
//