ID A0A0R4IKF9_DANRE Unreviewed; 816 AA.
AC A0A0R4IKF9; A0A8M2B361;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=CSC1-like protein 2 isoform X1 {ECO:0000313|RefSeq:XP_005157122.1};
DE SubName: Full=Transmembrane protein 63Ba {ECO:0000313|Ensembl:ENSDARP00000134798};
GN Name=tmem63ba {ECO:0000313|Ensembl:ENSDARP00000134798,
GN ECO:0000313|RefSeq:XP_005157122.1,
GN ECO:0000313|ZFIN:ZDB-GENE-030131-4320};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000134798};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000134798, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000134798};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000134798}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000134798};
RG Ensembl;
RL Submitted (NOV-2015) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_005157122.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_005157122.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
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DR EMBL; CABZ01073848; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01073849; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01073850; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01073851; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CU695232; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005157122.1; XM_005157065.4.
DR PaxDb; 7955-ENSDARP00000014328; -.
DR Ensembl; ENSDART00000160401; ENSDARP00000134798; ENSDARG00000104559.
DR Ensembl; ENSDART00000160401.2; ENSDARP00000134798.1; ENSDARG00000104559.2.
DR GeneID; 100334023; -.
DR AGR; ZFIN:ZDB-GENE-030131-4320; -.
DR CTD; 100334023; -.
DR ZFIN; ZDB-GENE-030131-4320; tmem63ba.
DR eggNOG; KOG1134; Eukaryota.
DR OMA; PKRYYAH; -.
DR OrthoDB; 231434at2759; -.
DR Proteomes; UP000000437; Chromosome 13.
DR Bgee; ENSDARG00000104559; Expressed in blastula and 21 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IBA:GO_Central.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR PANTHER; PTHR13018:SF38; CSC1-LIKE PROTEIN 2; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 38..57
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 154..174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 207..226
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 433..457
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 477..500
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 521..544
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 575..597
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 618..634
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 640..661
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 682..702
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 714..736
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 116..227
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 243..425
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 436..704
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT REGION 775..816
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 775..798
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 816 AA; 93684 MW; 348B3404E65F3398 CRC64;
MMIATGSTNN TNGTQDFCYS GRIRSTVLQG LPFGGVPTVL ALDFMCFLVL LCVFSFLRKV
AWDYGRLALV SDADSRRNKH YQRLDEQEYV ASAMQTPADS RYERLTSVSS SVDFDQRDNG
LCSWLTAIFR IKDDEIREKC GEDAVHYLSF QRHIIGLLVV VGVLSVGIVL PVNFSGDQLV
ETGNFENNNA YSFGRTTVVN LKSGNHLLWL HTIFAFFYLL LTVYSMRRHT SKMHYKEDDL
VKRTLFISGI AKYAEESEIK QHFEKAYENC VVLDARICYN VAKLMSLESE RKKAERSKKF
YTDLMSREHI PTMINPKPCG HLCCCIIKGC EQEEAVNYYT KLEAKLKEEY RKEREKVNTK
PLGMAFVTFQ NEAMAALILK DFNACQCHGC HCRRQPKSSP FSSQLHTYNW TVSYAPDPQN
VYWEHLSISG LNWWVRCFVI NCFLFLLLFF LTTPAIIIST MDKFNVTKPV EYLNNPIVTQ
FFPTLLLWCF SALLPTIVYY SAFFEAHWTR SGENRTTMHK CYTFLIFMVL LLPSLGLSSL
DLFFRWLFDK KFLDEATIRF RCVFLPDNGA FFVNYVIASA FIGNAMDLLR IPYFLMYMIR
LCLARSAAER RNVKKHQAYE FQFGAAYAWM MNVFTVVMTY SITCPIIVPF GLMYMLLKHL
VDRYNMYYAY LPSKLDKKIH SGAVNQVVAA PILCIFWLLF FSTVRQGFGA PTSMFTFVVL
IITIIICLSH IVFGHFKYLS AHNYKIDMDG VDNGRLRGSS PPVKSMQTYI AQVLQDPNSD
ETGSDQGQGS SQDEEGVTEG DFQSGEDSLI ENEVHQ
//
