ID A0A0R4ILK3_DANRE Unreviewed; 890 AA.
AC A0A0R4ILK3; A0A8M1NX98;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Rho GTPase-activating protein 11A {ECO:0000313|Ensembl:ENSDARP00000136955, ECO:0000313|RefSeq:NP_001180468.1};
GN Name=arhgap11a {ECO:0000313|Ensembl:ENSDARP00000136955,
GN ECO:0000313|RefSeq:NP_001180468.1,
GN ECO:0000313|ZFIN:ZDB-GENE-040426-2562};
GN Synonyms=wu:fc02e04 {ECO:0000313|RefSeq:NP_001180468.1}, wu:fc55g06
GN {ECO:0000313|RefSeq:NP_001180468.1}, wu:fe01b01
GN {ECO:0000313|RefSeq:NP_001180468.1}, zgc:77004
GN {ECO:0000313|RefSeq:NP_001180468.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000136955};
RN [1] {ECO:0000313|RefSeq:NP_001180468.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001180468.1};
RX PubMed=17703193; DOI=10.1038/sj.emboj.7601821;
RA Ferg M., Sanges R., Gehrig J., Kiss J., Bauer M., Lovas A., Szabo M.,
RA Yang L., Straehle U., Pankratz M.J., Olasz F., Stupka E., Muller F.;
RT "The TATA-binding protein regulates maternal mRNA degradation and
RT differential zygotic transcription in zebrafish.";
RL EMBO J. 26:3945-3956(2007).
RN [2] {ECO:0000313|RefSeq:NP_001180468.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001180468.1};
RX PubMed=19221799; DOI=10.1007/s00438-009-0428-8;
RA Maddison L.A., Lu J., Victoroff T., Scott E., Baier H., Chen W.;
RT "A gain-of-function screen in zebrafish identifies a guanylate cyclase with
RT a role in neuronal degeneration.";
RL Mol. Genet. Genomics 281:551-563(2009).
RN [3] {ECO:0000313|Ensembl:ENSDARP00000136955, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000136955};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [4] {ECO:0000313|Ensembl:ENSDARP00000136955}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000136955};
RG Ensembl;
RL Submitted (NOV-2015) to UniProtKB.
RN [5] {ECO:0000313|RefSeq:NP_001180468.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001180468.1};
RX PubMed=27189481;
RA Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I.,
RA Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y.,
RA Bobe J.;
RT "Gene evolution and gene expression after whole genome duplication in fish:
RT the PhyloFish database.";
RL BMC Genomics 17:368-368(2016).
RN [6] {ECO:0000313|RefSeq:NP_001180468.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001180468.1};
RX PubMed=29420541;
RA Sztal T.E., McKaige E.A., Williams C., Ruparelia A.A.,
RA Bryson-Richardson R.J.;
RT "Genetic compensation triggered by actin mutation prevents the muscle
RT damage caused by loss of actin protein.";
RL PLoS Genet. 14:e1007212-e1007212(2018).
RN [7] {ECO:0000313|RefSeq:NP_001180468.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001180468.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CU655844; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001180468.1; NM_001193539.1.
DR STRING; 7955.ENSDARP00000136955; -.
DR PaxDb; 7955-ENSDARP00000106792; -.
DR Ensembl; ENSDART00000172408; ENSDARP00000136955; ENSDARG00000100019.
DR Ensembl; ENSDART00000172408.2; ENSDARP00000136955.1; ENSDARG00000100019.2.
DR GeneID; 406608; -.
DR KEGG; dre:406608; -.
DR AGR; ZFIN:ZDB-GENE-040426-2562; -.
DR CTD; 9824; -.
DR ZFIN; ZDB-GENE-040426-2562; arhgap11a.
DR eggNOG; KOG2710; Eukaryota.
DR OMA; RQPIRHK; -.
DR OrthoDB; 25176at2759; -.
DR Reactome; R-DRE-8980692; RHOA GTPase cycle.
DR Proteomes; UP000000437; Chromosome 17.
DR Bgee; ENSDARG00000100019; Expressed in gastrula and 28 other cell types or tissues.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd04394; RhoGAP-ARHGAP11A; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR042869; ARHGAP11A/B.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR15670; RHO GTPASE ACTIVATING PROTEIN 11A; 1.
DR PANTHER; PTHR15670:SF4; RHO GTPASE-ACTIVATING PROTEIN 11A; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT DOMAIN 46..237
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 321..341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 382..427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 508..530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 586..615
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 890 AA; 97557 MW; F02BFBE6E129E04A CRC64;
MRVLERNVVR LAVVQHLRSV YGIRIKNWNK NRSKQTSANT VRVFGVALEG LPHSHVLDYG
DLPCFLVDIC TTLLDHLDTE GLFRKSGSVV RVKSLRAKLD QGEDCLSAAL PLDIAGLLKQ
FFRELPEPVL TVDLHSAFLK AQELPTAEER TSATVLLSCV LPDTNLNTLR YFFSFLKTVS
QRCAENKMDS SNLAVIFAPN LFHCGDGGEK MSSSTEKRLK HQAAAVQCLI ENAQRIGVVP
QFLMEKVPAM LGCDAAVFSP SAVSPEDSNA HFDLKKSNRR SLGDVVNGAL NRLKASRTPT
NTPHSDGAVF SMATPVIMTP NSKRKLPLES SQTHGFSNKK RRSIKKNLGL ELFPSVLFGG
TSTPGSTHSA AGVLDSSHSG LLSSVGRNSR LSSSSARRKS RRLRDRSVSR VESGKAGCFS
PRTAKKEPVR KSLRLRFSLG KSSRDSNLIT HSQPVPKGSE VIGWRLATQE SSTGFHFTKE
LSLPVLSKSP SKGSKFFSKS EDNLSTPQCD FTDHRSSWTG ETPETGLTFP TDSFSETPLI
IVSKPPTISS VPETTPEECS HTGHTLLKIR QAFGESGSDL HSIITQKDQQ DDSSNVHLPS
ETAHKSISES GQSNDDVTFG QIEIVPLSPL HIDSALFDSE PTRFVETSLN GSLCFKNEYL
KESAVRSVNC SQIIDALDIQ SPVAFRLDTS TRVQSTPYAT RSQVNANTSL QDELRASSLV
EKKIESSQEQ QNNAESKKSK VADQIKLFNM MTLHSPKVQL LRSPLKFQRT PVRQSVTRIN
SLAGKRKESR MGWCAASQVK AVSLESGLYS SVKPKPPVPL KKTAVKPAAL EDITNKAPKA
MLSNCKNAAD EHPKCVLLKV SENDTSHYRG SPRHPLVEGR LLSAMKPIDL
//