ID A0A0R4IVC0_DANRE Unreviewed; 499 AA.
AC A0A0R4IVC0; A0A8M2BGY1;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Heterogeneous nuclear ribonucleoprotein L2 {ECO:0000313|Ensembl:ENSDARP00000139075, ECO:0000313|RefSeq:XP_005169750.1};
GN Name=hnrnpl2 {ECO:0000313|Ensembl:ENSDARP00000139075,
GN ECO:0000313|RefSeq:XP_005169750.1,
GN ECO:0000313|ZFIN:ZDB-GENE-040426-2707};
GN Synonyms=hnrnpl {ECO:0000313|RefSeq:XP_005169750.1}, hnrpl
GN {ECO:0000313|RefSeq:XP_005169750.1}, wu:fb53f10
GN {ECO:0000313|RefSeq:XP_005169750.1}, wu:fp61c04
GN {ECO:0000313|RefSeq:XP_005169750.1}, zgc:66175
GN {ECO:0000313|RefSeq:XP_005169750.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000139075};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000139075, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000139075};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000139075}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000139075};
RG Ensembl;
RL Submitted (NOV-2015) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_005169750.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_005169750.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BX088654; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005169750.1; XM_005169693.4.
DR Ensembl; ENSDART00000171528; ENSDARP00000139075; ENSDARG00000059303.
DR Ensembl; ENSDART00000171528.2; ENSDARP00000139075.1; ENSDARG00000059303.7.
DR GeneID; 573096; -.
DR AGR; ZFIN:ZDB-GENE-040426-2707; -.
DR CTD; 573096; -.
DR ZFIN; ZDB-GENE-040426-2707; hnrnpl2.
DR OrthoDB; 4825346at2759; -.
DR Proteomes; UP000000437; Chromosome 15.
DR Bgee; ENSDARG00000059303; Expressed in early embryo and 27 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProtKB-KW.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR GO; GO:0043484; P:regulation of RNA splicing; IBA:GO_Central.
DR GO; GO:0048742; P:regulation of skeletal muscle fiber development; IMP:ZFIN.
DR CDD; cd12780; RRM1_hnRNPL; 1.
DR CDD; cd12785; RRM2_hnRNPL; 1.
DR CDD; cd12699; RRM3_hnRNPL; 1.
DR Gene3D; 3.30.70.330; -; 4.
DR InterPro; IPR006536; HnRNP-L/PTB.
DR InterPro; IPR034816; hnRNP-L_RRM3.
DR InterPro; IPR035005; hnRNPL_RRM1.
DR InterPro; IPR035008; hnRNPL_RRM2.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR021790; PTBP1-like_RRM2.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR NCBIfam; TIGR01649; hnRNP-L_PTB; 1.
DR PANTHER; PTHR15592:SF20; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN L; 1.
DR PANTHER; PTHR15592; MATRIN 3/NUCLEAR PROTEIN 220-RELATED; 1.
DR Pfam; PF13893; RRM_5; 1.
DR Pfam; PF11835; RRM_8; 1.
DR SMART; SM00360; RRM; 3.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 3.
DR PROSITE; PS50102; RRM; 3.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A0R4IVC0};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ribonucleoprotein {ECO:0000313|RefSeq:XP_005169750.1};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}.
FT DOMAIN 42..116
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 133..210
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 289..363
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 247..283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 499 AA; 55160 MW; 4558E72F3542D3FA CRC64;
MATQTARFYS EGGRATKRQK TENEGGMATE GYTDPHKTLP SLVVHVRGLV DGVLESDIVE
ALQEFGTISY VVLMPKKRQA LVEYEDMNGS CNAVTYANDN QIYIAGHPAF VNYSTSQKIS
RPGDPDDARS VNNVLLLTIM NPIYPITSDV LYTICNNCGP VQRIVIFRKN GVQAMVEFDS
VQSAQRAKAS LNGADIYSGC CTLKIEYAKP TRLNVFKNDQ DTWDYTNPSL GTQGGYPGYP
DESYGYEGRR MGPPMSAPRR GGASQRYSAQ YGGPPPPPPG EYGAHADSPV IMVYGLDPVK
INADRVFNIF CLYGNVERVK FMKSKPGAAM VEMGDCYAVD RAISHLNNNF LFNQKLNLCV
SKQQAIMPGQ SYELDDGTNS FKDYHGSRNN RFATPEQAAK NRIQHPSNVL HFFNAVPEAT
PEMFTRLCEE HGVKNPSNIK IFVAKGNSPD RSSSGLLEWE SVNDAMEALA MINHNQMKNP
NGPYPFTLKL CFSTAQHAN
//
