ID A0A0R4IWH1_DANRE Unreviewed; 974 AA.
AC A0A0R4IWH1; A0A8M2BD26;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Si:dkeyp-117b8.4 {ECO:0000313|Ensembl:ENSDARP00000141151};
DE SubName: Full=Zinc finger BED domain-containing protein 4-like isoform X1 {ECO:0000313|RefSeq:XP_005165631.1};
GN Name=si:dkeyp-117b8.4 {ECO:0000313|Ensembl:ENSDARP00000141151,
GN ECO:0000313|RefSeq:XP_005165631.1,
GN ECO:0000313|ZFIN:ZDB-GENE-060526-362};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000141151};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000141151, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000141151};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000141151}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000141151};
RG Ensembl;
RL Submitted (NOV-2015) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_005165631.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_005165631.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BX511157; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR759879; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005165631.1; XM_005165574.4.
DR Ensembl; ENSDART00000168808; ENSDARP00000141151; ENSDARG00000094214.
DR Ensembl; ENSDART00000168808.2; ENSDARP00000141151.1; ENSDARG00000094214.3.
DR GeneID; 101884515; -.
DR KEGG; dre:101884515; -.
DR AGR; ZFIN:ZDB-GENE-060526-362; -.
DR ZFIN; ZDB-GENE-060526-362; si:dkeyp-117b8.4.
DR OMA; REKICER; -.
DR OrthoDB; 2967960at2759; -.
DR Proteomes; UP000000437; Chromosome 5.
DR Bgee; ENSDARG00000094214; Expressed in blastula and 20 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR008906; HATC_C_dom.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR003656; Znf_BED.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR PANTHER; PTHR46169; DNA REPLICATION-RELATED ELEMENT FACTOR, ISOFORM A; 1.
DR PANTHER; PTHR46169:SF23; INNER CENTROMERE PROTEIN A-LIKE ISOFORM X1-RELATED; 1.
DR Pfam; PF05699; Dimer_Tnp_hAT; 1.
DR Pfam; PF02892; zf-BED; 2.
DR SMART; SM00614; ZnF_BED; 2.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 2.
DR SUPFAM; SSF140996; Hermes dimerisation domain; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50808; ZF_BED; 2.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00027}.
FT DOMAIN 18..69
FT /note="BED-type"
FT /evidence="ECO:0000259|PROSITE:PS50808"
FT DOMAIN 117..160
FT /note="BED-type"
FT /evidence="ECO:0000259|PROSITE:PS50808"
FT REGION 447..473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 719..763
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 782..807
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 974 AA; 108890 MW; 1E82D40AA5D817C4 CRC64;
MANMKQEELE ISGKTQARYC SVAWKYYIKN ELNGTVYCRL CKSTFKFSSN TANMIKHLRV
KHRLNIPTVA NGGERLCTEE PSERNMDMDL PPPRHPGIHS SPILRRRMQR FLPFSDRRTS
KVWNHYTQLS LHRVECNHCK RQLSFHNSTT SMREHLGRKH SIREGVVPPH NTAGIPTPGA
LHSHIQSTLH GNRCNNTGNV TFQPLLPVTV KEEHEEILPA EMGEAKAART SYAPDCAPGS
STSGSNAITH QDTDMGCLMY NFPAGEMSST AGGSSSRCGT RACSNKRAEV LTDLILEMVF
RDLQPLSVVE ERGFKLLLSC LEPNYPVPSP SLLGSLLWHR YHVLKQCLQQ HLQTSLASHY
MTLCTEYWRS VEGCGVGGDG QYYLSVSAHF IDSQWRLARC MLETRPIAEL KGNPSERGQV
SFADTLKAVL SEFQLSENSV FCVMHDTPSD SESRQSIDRE FPQEFPGPSH PPPRKLPKGW
APLLCAGQAL KLCVQEGLCV ESVRQALADA RAIVLHFQHN VGASTALSQK AEAVNKESAS
LVLNDPGRWT TAIDMCESLL ELKWVISSVL EEQKIATNLA DHQWRLVHEL VPVLKTVRIA
ASFLSEDING PISALMPCLQ GVSRLLGQKI ADCTCPVVRG VMERIRAGMD KRWSLSDEDA
LLDCPAVLSS FLDPRFKELR FLSPHARSKL HDKVKELLSV QAFTSNEGLN EDRRQRMEME
EALDEHGDPA DFGLDDSLPI PPMGSLDSPE SCGSLEEGDS VELQPSELSV AVSSPEQVND
NALEVGSPFK NTNERKRRSS GATMTSPVRG DLQLTSRIRM SPLPQSMYDI LLGEDPTERM
PEIHQQLENY IAEPLCRRSL SPLQWWRSKE HRFPAVARLA RKYLSIPATA VSANRAFAPR
ESPVTQRRAT LGSKHLNHIL FLHQNADYLD QLKGGSSARE IDQWNSVSGN QSRESLYQTL
VSYESKVRVP EEES
//
