ID A0A0R4J094_MOUSE Unreviewed; 313 AA.
AC A0A0R4J094;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Fumarylacetoacetate hydrolase domain containing 2A {ECO:0000313|Ensembl:ENSMUSP00000028848.4};
GN Name=Fahd2a {ECO:0000313|Ensembl:ENSMUSP00000028848.4,
GN ECO:0000313|MGI:MGI:1915376};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000028848.4, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000028848.4, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000028848.4,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0007829|PubMed:23806337}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
RA Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y.,
RA Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
RT "SIRT5-mediated lysine desuccinylation impacts diverse metabolic
RT pathways.";
RL Mol. Cell 50:919-930(2013).
RN [4] {ECO:0007829|PubMed:23576753}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=23576753; DOI=10.1073/pnas.1302961110;
RA Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B.,
RA Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.;
RT "Label-free quantitative proteomics of the lysine acetylome in mitochondria
RT identifies substrates of SIRT3 in metabolic pathways.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013).
RN [5] {ECO:0000313|Ensembl:ENSMUSP00000028848.4}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000028848.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May have hydrolase activity. {ECO:0000256|ARBA:ARBA00037111}.
CC -!- SIMILARITY: Belongs to the FAH family. {ECO:0000256|ARBA:ARBA00010211}.
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DR RefSeq; NP_083905.1; NM_029629.2.
DR AlphaFoldDB; A0A0R4J094; -.
DR SMR; A0A0R4J094; -.
DR EPD; A0A0R4J094; -.
DR jPOST; A0A0R4J094; -.
DR ProteomicsDB; 318042; -.
DR Antibodypedia; 35241; 393 antibodies from 19 providers.
DR DNASU; 68126; -.
DR Ensembl; ENSMUST00000028848.4; ENSMUSP00000028848.4; ENSMUSG00000027371.11.
DR GeneID; 68126; -.
DR KEGG; mmu:68126; -.
DR AGR; MGI:1915376; -.
DR CTD; 51011; -.
DR MGI; MGI:1915376; Fahd2a.
DR VEuPathDB; HostDB:ENSMUSG00000027371; -.
DR GeneTree; ENSGT00940000160571; -.
DR OMA; YSVAQDI; -.
DR OrthoDB; 9433at2759; -.
DR PhylomeDB; A0A0R4J094; -.
DR BioGRID-ORCS; 68126; 1 hit in 78 CRISPR screens.
DR Proteomes; UP000000589; Chromosome 2.
DR Bgee; ENSMUSG00000027371; Expressed in interventricular septum and 228 other cell types or tissues.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR Gene3D; 3.90.850.10; Fumarylacetoacetase-like, C-terminal domain; 1.
DR InterPro; IPR011234; Fumarylacetoacetase-like_C.
DR InterPro; IPR036663; Fumarylacetoacetase_C_sf.
DR PANTHER; PTHR42796:SF4; FUMARYLACETOACETATE HYDROLASE DOMAIN-CONTAINING PROTEIN 2A; 1.
DR PANTHER; PTHR42796; FUMARYLACETOACETATE HYDROLASE DOMAIN-CONTAINING PROTEIN 2A-RELATED; 1.
DR Pfam; PF01557; FAA_hydrolase; 1.
DR SUPFAM; SSF56529; FAH; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:A0A0R4J094,
KW ECO:0007829|MaxQB:A0A0R4J094};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 107..313
FT /note="Fumarylacetoacetase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01557"
SQ SEQUENCE 313 AA; 34676 MW; 350AFD416B8D6FBC CRC64;
MLGFGRRRLF SALLQVQKRP CQPSRNMRLV QFQAPHLEEP HLGLESGVGG GVVDLNAFDS
TLPKTMVQFL EQGETTLSVA RRALATQLPV IPRSQVTFLA PVTRPDKVIC VGLNYADHCQ
EQNVRVPKSP IIFSKFSSSI VGPYDEIILP PESKEVDWEV EMAVVIGKKG KHIKATDVMA
HVAGFTVAHD VSARDWQMRN GKQWLLGKTF DTFCPLGPAL VTKDTIADPH NLKICCRVNG
EVVQSSNTNQ MVFKTEYLIA WVSQFVTLYP GDLLLTGTPP GVGMFRKPPV FLKKGDEVQC
EIEELGVIIN KVV
//
