ID A0A0S4IWW6_BODSA Unreviewed; 4193 AA.
AC A0A0S4IWW6;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Dynein heavy chain, putative {ECO:0000313|EMBL:CUG01466.1};
GN ORFNames=BSAL_04460 {ECO:0000313|EMBL:CUG01466.1};
OS Bodo saltans (Flagellated protozoan).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Eubodonida; Bodonidae; Bodo.
OX NCBI_TaxID=75058 {ECO:0000313|EMBL:CUG01466.1, ECO:0000313|Proteomes:UP000051952};
RN [1] {ECO:0000313|Proteomes:UP000051952}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Lake Konstanz {ECO:0000313|Proteomes:UP000051952};
RG Pathogen Informatics;
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CYKH01000493; CUG01466.1; -; Genomic_DNA.
DR VEuPathDB; TriTrypDB:BSAL_04460; -.
DR OMA; HELVKYN; -.
DR OrthoDB; 168388at2759; -.
DR Proteomes; UP000051952; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF34; DYNEIN HEAVY CHAIN, CYTOPLASMIC; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000051952}.
FT DOMAIN 1464..1603
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1746..1889
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2102..2252
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 1..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 373..393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 444..488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 769..811
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1178..1205
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2765..2799
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2939..3022
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..51
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 375..393
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 446..488
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4193 AA; 476481 MW; 3CBAC7F147235548 CRC64;
MSHSPAKQSM SPAPPAATKS VHRNPNLVAK LAAESTGGSN PLLNRLYSSS VPQAPGAPPP
GVPNILSQTK KADAAVGAAN GSNNGVKDLA KTAPSGAMAA PNTTYHNSLQ LFTQPTLQEG
ELKQLLLSTN TVKPHIRRQT PPSRLLPLVP LNDTLTGEPL EESKEGTPAV ASKFRNTHAN
TPKEFTYLTM RPVGVRDMYN PYDLQVASHK DIAPTQYFTV SAAGVTKFDE GEAEFMELKS
WEREHQIFHK LIDLNIFKHY KRWKSFLAWR KLVRRTTIQT YKTHLNDNLF HLHPNLSGTL
RVVRKICLDF LAQNNLYILA TETRTLDQFC TTLNSHLNFQ RNRLDRMIRD IRDEMERSCK
AAMLTAQATR EKAMAHGAEA TEEKRRKKTE FKDIGAQHKP SYIELSQKRA VCRRLTAFIR
LCDYVVIHCL TNLAMKAIQD AHNDVQFPRP PKKEEEKPVE KDPKDHRHHP HGPEGGKPGD
KKKKDEKSGP FEGMIFNVDV LYSSDEESIQ VKPGLSSFTQ RIEEIMKDYV KTVSAVPRFA
QMETFKVYTE QGMMDGGGDD SVMGPDVGEM VTCEEKYKNL MVNIRNSLTK SFQSVDQYAH
EFDPFRNMYL RNCRLDTQEI RRRNEAMDFF RDRIQLYKQQ SEDIEKKIPN TKDVGLCSVH
TDALREHFSP SPVACLRAFH ELLPIIAHEK NDAMLKDLVA CNRFLEVAPE TVEQYAEYTA
YVLGLENRIE QVNADFEFLR ELFVLIIDEK VSINEEDEDT YRSGTRPQFE KLRTLMTGVE
DNKESLQRNF CRNIDEQIEG LRDNITEVQA LAEHKMIADD NADVETVITY VSDLQTRAEA
IAAREKELRR FQIAFGSEET PIDNLSDMLQ DVSVKARLWT SLRDWDGVVE QYCAVPFVDL
DPPTVQDQIQ KYVMTVKQVS SRLPNNLAVP KLKGKVEEWR QLAPVILALK NPKLKQEHTS
KLSQTIGKVT DADGNERYIH EMEKVFTLGM LLNNNILQMR EEILAISVAA TEEDKLQQMI
DKVNAMWNGG GAKPAIEFQY LNHKELKDVY VISGGSVEDV TALLEDSLVA VSTIGSSRFC
LGVLKVQVDR WETRLRYMQE TLEKWLEFQR NWMYLENIFS SSEIRNQWKD DAKRFEGADK
FFRDFMRKAH DTPNAFRAML INAPSFDENT AQSGRTLKQD FEVNNRELEK VLASLERKLE
EKRRAFPRFY FLSNDDLLDI LAKVKQPELI MAHMLKMFDG IKSLTFTANN DITHLLSMEG
EKVELQQKNV KARGPVETWL GSLEREMFST LRKLAKIALD DYEARNDRAA WIFQHPVQLA
LIISQIFWTR GVEVALDQPN SKELMKGVRD TNYRQLAELA GLTARKLNKV QRITLSTLIT
LDVHGRDLVD EMYENDVVSS AEFGWTKQLR IYWEQDEDGD GNAFIRQNNS RFVYGYEYLG
AQGRLVITPL TDRVYMTITG ALKLYLGAAP AGPAGTGKTE TTKDLAKNLA RQCIVYNCSD
GVTYKMMEKF FSGLIQTGAW TCLDEFNRIN IEVLSVIASQ VLEIKLALQS GADSFTFQGT
PNVRIRPTYG AFITMNPGYA GRTELPDNLK ILFRPVAVMT PDFRMIAEVI LYSEGFKNAK
DLSLKITQLY KLSSEQLSPQ DHYDFGMRAL KSILVMAGDL KRSQPHVEED LTLIVACNDS
NVPKFVAEDL PLFRGIMQDL FPGTSFPERE YPELLPAMQK DMKAKSLKAV TTWINKGIQF
YETLIVRHGV MLVGVTGTGK SESRNTIANA LVTMHQNGSH EHLARPVNQF VLNPKSILMH
ELYGVLDVMT NEWKDGVLAV IAKNCVKDSE GCDEHRWIVF DGPVDTLWIE SMNSVLDDSK
LLCLDNGERI KLPDTIHMIF EVADLSVASP ATVSRCGMVY VDSNDLQWDA PVYQWARTKL
VETSAQPQCR EYIVSLFDRF APQGMAWIAK QKVLIDAGPM NLSQSLCDLY SAMLVVNNIK
LMADPVGETI IAPDDAIFRE RNEVCNQLFV FAFVWSIGGN IDLATQDIFD AWARELFEGF
VRIPNSGTVF DMCIDFTSRS FVSWETRVKE FKYDPKIPFF DVLVPTVDTV RFATLARTLI
AYKKPLLFNG QTGVGKSVIM ADCLSVNKTD LNLVLIIFQF SAQTSSERTQ ELIESKLKQK
RKNILGAPPD REVILFIDDL NMPALEVFGA SPPIELLRQI MGNGGFYDRK IAGFWKFVQD
VTVVSACGPP EGGRNPVTAR LTRMFHLMQI PNLSEDSMKR IFTSILSGYF DDKNFSKEVK
DLARNMITGT VEVFAKIREE LRPRPTTPHY TFNLRDLAKV TQGLMQVVPR MCKDGNSATR
LWIHETMRCL YDRLTSAEDR RLFTEEFMMD CLRRLFPGNH SHEEYFEKEP LVWGDFLKFG
AAEKFYEEAT EFKKVYRLFD EYLDDYNASV TSSKDDVQSS SMNLVFFRDH CEHLARIVRI
IKQPRGNALL VGVGGSGKRS LTRLATHIAD YKRFEIAVGK GYGMNEFHES LLELYTNAGV
KCTPLVFLIS DNQIVNEGML EDINNMLNSG EVPSLFSPEE RDKKINACME AAREAGFTHR
DEVYNYFISR VRDNMHIVLC MSPVGDAFRT RCRQFPSLTN CCVIDWFDEW PEEALRGVAV
RLMAEVDLEK NPEVREPLTE LCVDIHQAVV HTSNEYWDEL RRRYYITPTA YLEFIKLYKS
TLNERGSDLS EQLSRIVNGM LKMKQTDEII AVMKKEIEEK QPMLEKASKD TELVVADLKV
RQEKAEIVQT QVRAQQESAA EMQKQASEIA RDANEKLAEA KPIIQRAQAA LDTIQGSDLN
ELRSFANPPA AVLKTSQACM TMFDNKDFNG AWSGGMDWKG AREFLSFRPL LDMIKSYPVE
AVKPQVLMRV QKFINDEEFT VEICSAKGSQ TCGSLCAWVR AVNEYSKVVK EVAPKRAAAA
EAEKMLAETN EKLMAAKAQL KSVEDELQTL QTNYEVSLKR KTDLENGLKI CISRLSNAET
LSACLKSEAV RWEENIRKFE ARLKVLPLDI FMSCASMNYS GAFTPRFRKR LLHLWMEKVA
QRGMTLENFS LVESMGNPME ILTWQINGLP TDENSTENAI VVAMSTPPRR FPLLIDPQGQ
AVKWLTQQYN QPRNGQKPNF KIVKLTDSTY MRSLEAAIRM GGTIIVDDVG ETIDPALEPL
LMRQIFTAEG GGPQIQMSAQ SGPIDYNPAF RFFMCTKLPN PHYLPDISTK VTMLNFTVTM
DGLEDQMLGE VVSIEKRELE EEKNKIIHSI SEGQKKLKVI EETVLEKLKN TKGNILDDKD
LINELKSAQV NAGVLGKKQE EAREKMKIIN VTRELYRSVA TRCAVLFFVL ADLSLIDPMY
QYSLEYFKTL VCKVVEATKK PEGFNEADPT QDSLNDHLAN LMERITETTY VQICRGLFNK
DKTILSLLIC TSIARNCDEI IDQEWQYFVR ASALVAGEVP PKPEGLEWMS QVQWELLDTI
NRLVPCYKGI SDDVKNRTEL WREFVLGEAP QDATLPGGGA TEADAAGRDW EHTLEPFQRI
LLIRCFREEK LLFALTTYVR VRMGNHYVEP PAFSLERAMG DSSSSTPIVF ILSPGADPMN
MLQAFAATNG KQLQYVSLGQ GQGENAKRLI ETCRKSGDWA MLQNCHLSKT FMPELEIQVA
QLQQVSSNVN PNFRLWLTSM PTDFFPVFVL QNSVKLTNEP PTGLKANMIR CFNEITDGDF
EVFNKGENFP ECSKEHAYKK LMYGLCFFHS VVLERKKFGP LGWNVKYEWN DTDFHVSKQW
LRLFLEEQAN IPWDSLEYII GQINYGGRVT DPLDRNTLMT VLRIYLNRSI LLDGYSFSQS
GKYRAPPIGS ITSFRTVLQD MSLIDDPEVF GMHENANLRY QLQVSELLMS TVLSIQPRLI
AKKGGGPTPE ELVMQKCVDF EASLPSNIDK EEAGPNTFTT LANGLPNSIS TVLSHELVKY
NKLLTRMRWS LLELQKALKG LTVLSEDLDK MYQSFLNDQV PALWSSVGYA SLKPLGAWYR
EFLNKINFIR TWVQKGEPVS FWITGFFNPS AFMTGVLQAF ARAEAVSVDK LGFSFQVTDE
EADEVTKQPH RGCYVHGIFT DAWRWDKEKR VMMDSLPGEP YSTLPVVHFL PEPNHKTPNN
FHRVPMYRTT IRAGIISSLG ASSNYVLPIE APTDKDPDYW VLKGAACAIA LNA
//
