ID   A0A0S4J3Q2_BODSA        Unreviewed;       624 AA.
AC   A0A0S4J3Q2;
DT   17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT   17-FEB-2016, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=adenylate cyclase {ECO:0000256|ARBA:ARBA00012201};
DE            EC=4.6.1.1 {ECO:0000256|ARBA:ARBA00012201};
DE   AltName: Full=ATP pyrophosphate-lyase {ECO:0000256|ARBA:ARBA00032597};
DE   AltName: Full=Adenylyl cyclase {ECO:0000256|ARBA:ARBA00032637};
GN   ORFNames=BSAL_84110 {ECO:0000313|EMBL:CUG73032.1};
OS   Bodo saltans (Flagellated protozoan).
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Eubodonida; Bodonidae; Bodo.
OX   NCBI_TaxID=75058 {ECO:0000313|EMBL:CUG73032.1, ECO:0000313|Proteomes:UP000051952};
RN   [1] {ECO:0000313|Proteomes:UP000051952}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Lake Konstanz {ECO:0000313|Proteomes:UP000051952};
RG   Pathogen Informatics;
RL   Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Could act as a receptor for an unknown ligand.
CC       {ECO:0000256|ARBA:ARBA00002708}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001593};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-3 family.
CC       {ECO:0000256|ARBA:ARBA00005381}.
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DR   EMBL; CYKH01000960; CUG73032.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0S4J3Q2; -.
DR   VEuPathDB; TriTrypDB:BSAL_84110; -.
DR   OrthoDB; 5470792at2759; -.
DR   Proteomes; UP000051952; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006171; P:cAMP biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR   PANTHER; PTHR43081:SF1; PH-SENSITIVE ADENYLATE CYCLASE RV1264; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   3: Inferred from homology;
KW   cAMP biosynthesis {ECO:0000256|ARBA:ARBA00022998};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Reference proteome {ECO:0000313|Proteomes:UP000051952};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        225..251
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          268..408
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   624 AA;  68007 MW;  013345F719BF75CC CRC64;
     MWDDERIAAT NPLLTLPRAA IQVVVRSDSS GSTSVLTNGL AALEAACSVP NPIFRESTTW
     VFGSHVTLVT SAAQSSFVRT TPYALSYIVY PTAIQDGHQI ASVFDTDSQV TTTALVSSSK
     LASFAVVNTT TLEVTFSTSA TFYPFVGVSY ALLDANRPRN CSEFAYIANF LLWTIKNPIP
     LALADDLNYI SVPSSLSDLV TTVLQDRLSC AGNLLFPKQV EENHIAAIVA GVVVPTVLLL
     VAMFVWLTFF AGKRNNSSAP KDANKPVAMA FTDIQASTTL WASVPTVMAR ALDLHNSILR
     ECLARNSGYE VKTIGDAFMI AFSSVEDAVR FALDAQKELY DANWETEDID AVYEDMADDK
     GLTTIPELWN GLRVRIGVHC GLLDIHLDPV TLGYDYHGTV VNTTARVEDA GHGGQVVVTQ
     DVMDALPNDF LSLHRVDVKG IGATELRGLP QPVVLTQLLP EAFAARSFPP LRVEKESALL
     EDDDNDVTDT GTEQSNQTAH INTMLLKVFP VAATVDVLFS AMTSGDALPI VRKISQSWGL
     HVSKKATDVN VFYRRLAVRC SEVLSVRSDR MRRGSRLTAT DTNSVMSAAS KKVDKLFTKV
     SAKYEFVEEI SEESDHGLHR PQKK
//