ID A0A0S4KIZ4_BODSA Unreviewed; 972 AA.
AC A0A0S4KIZ4;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=BSAL_88110 {ECO:0000313|EMBL:CUI14417.1};
OS Bodo saltans (Flagellated protozoan).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Eubodonida; Bodonidae; Bodo.
OX NCBI_TaxID=75058 {ECO:0000313|EMBL:CUI14417.1, ECO:0000313|Proteomes:UP000051952};
RN [1] {ECO:0000313|Proteomes:UP000051952}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Lake Konstanz {ECO:0000313|Proteomes:UP000051952};
RG Pathogen Informatics;
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC {ECO:0000256|ARBA:ARBA00008792}.
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DR EMBL; CYKH01001107; CUI14417.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0S4KIZ4; -.
DR VEuPathDB; TriTrypDB:BSAL_88110; -.
DR OMA; FRIEWTS; -.
DR OrthoDB; 5490433at2759; -.
DR Proteomes; UP000051952; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd17982; DEXHc_DHX37; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF99; ATP-DEPENDENT RNA HELICASE DHX37-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Helicase {ECO:0000313|EMBL:CUI14417.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000051952}.
FT DOMAIN 110..296
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 456..627
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 381..404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 441..492
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 800..830
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 771..798
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 389..404
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 457..472
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 972 AA; 108094 MW; CA84D955194F8BD2 CRC64;
MSSARTKETE RKRELKAEHV KCQNERNKAA KERDAKVVKD IVVITQKVQA AIFEEEHRLE
EVRKLIAEQD AKDIEAATPA IHIDVFRRPE IAETRADLPV MREEQGIVEA INEAPGGCVL
ICGETGSGKT TQIPQFLWEC GYGHEEGAVM GRQGMIVVTE PRRVAAVSMA QRVADELNEP
FGETVSYQVR YDNNLSSNTK MKFATEGILL REIHGDFLLK NYSVVIVDEA HERSVSGDLL
IGMLSRIVPL RASLAAEGTI IEGQKITPLK LVIMSATMRV SDFRDNRVLL PREPPMLNVE
ARRFPVTNHF AKKTELRNYC DEAFRKVTQI HKKLPPGGIL MFLCTQREID AMCDRLRRHY
RKTRIVYDES NFKKHAMLSM AAHKKHGKKP PPAGGEDERQ EEKDKYGLLS EQYALDGDSG
FGRPSSALED FGLRDDFHYE DEDEEDDESG AAQPLQEDKL GEEEREDVAS SDGAESADSA
EAFEAPQEDE EDGAFDSLHV LPLYSLLNFK DQQLVFQDPP PGKRLCVVAT NVAETSITIP
GIRYVVDCGR VKNKTLDASS GASAFSIEWT SQASSEQRSG RAGRTAPGHS YKLYSTAVYA
NLMPKHSVPE ILRTPIESVV LLMKSLAIEH VSKFPFPTAP RKEDIEVATK HLVVLGAVDQ
KSLRITPIGE SLAHFPVAPK YAKMILTALK IGNPVIVDLV IAMVAVCATT LDVFDHGTVQ
EALRKEQTGT HRVADQKRLL HAGSDMISFV RALGVFGHRP SFATATRFNI VHKSMTEAQQ
LRRQLNGATK NMKGREEALF SENTDDGEDD SEKVDDESAT PSSSTLTSSK AFDANGDVKL
TKDTEVLLRK LIAVGLMDQI ARKASVHECR SRGVEFTTGK TTKVPYLDVR SGSVVYIHPS
STVSSTHPAP EYVAYCGLQR SRRVQEGTSV STKKKIDHTF MKGVTVLAKE WLDAVEYDED
VVIRIYQQQM DV
//
