ID A0A0S7BX49_9CHLR Unreviewed; 352 AA.
AC A0A0S7BX49;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Aspartate-semialdehyde dehydrogenase {ECO:0000313|EMBL:GAP41526.1};
GN ORFNames=ATC1_131518 {ECO:0000313|EMBL:GAP41526.1};
OS Flexilinea flocculi.
OC Bacteria; Chloroflexota; Anaerolineae; Anaerolineales; Anaerolineaceae;
OC Flexilinea.
OX NCBI_TaxID=1678840 {ECO:0000313|EMBL:GAP41526.1};
RN [1] {ECO:0000313|EMBL:GAP41526.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TC1 {ECO:0000313|EMBL:GAP41526.1};
RA Matsuura N., Tourlousse D.M., Sun L., Toyonaga M., Kuroda K., Ohashi A.,
RA Cruz R., Yamaguchi T., Sekiguchi Y.;
RT "Draft Genome Sequence of Anaerolineae Strain TC1, a Novel Isolate from a
RT Methanogenic Wastewater Treatment System.";
RL Genome Announc. 3:e01104-15(2015).
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DR EMBL; DF968181; GAP41526.1; -; Genomic_DNA.
DR RefSeq; WP_062282926.1; NZ_DF968181.1.
DR AlphaFoldDB; A0A0S7BX49; -.
DR STRING; 1678840.ATC1_131518; -.
DR PATRIC; fig|1678840.3.peg.2995; -.
DR OrthoDB; 9805684at2; -.
DR Proteomes; UP000053370; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0008652; P:amino acid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR005676; Asp_semi-ald_DH_pep-lack.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR000534; Semialdehyde_DH_NAD-bd.
DR InterPro; IPR012280; Semialdhyde_DH_dimer_dom.
DR NCBIfam; TIGR00978; asd_EA; 1.
DR PANTHER; PTHR46718; ASPARTATE-SEMIALDEHYDE DEHYDROGENASE; 1.
DR PANTHER; PTHR46718:SF1; ASPARTATE-SEMIALDEHYDE DEHYDROGENASE; 1.
DR Pfam; PF01118; Semialdhyde_dh; 1.
DR Pfam; PF02774; Semialdhyde_dhC; 1.
DR PIRSF; PIRSF000148; ASA_dh; 1.
DR SMART; SM00859; Semialdhyde_dh; 1.
DR SUPFAM; SSF55347; Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000053370}.
FT DOMAIN 6..132
FT /note="Semialdehyde dehydrogenase NAD-binding"
FT /evidence="ECO:0000259|SMART:SM00859"
FT ACT_SITE 151
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000148-1"
FT ACT_SITE 244
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000148-1"
SQ SEQUENCE 352 AA; 38521 MW; A764B506F9FC0195 CRC64;
MKNKIPVAVL AATGSVGQRF ISLLENHPWF EVVEITASDR SVGKTYQEAC HWLITDPMPE
SVKNLTLLPT EANSLQKSVF AFSALPADIA KNVEPDFARK GIYVCSNASA YRKDPLVPIL
VPEVNANHLD ILDIQQKTYG WSGGIITNPN CTTCAFVVPL NAIDKAYGVQ KAIVFSMQAI
SGAGYPGVAS MDIIDNVIPY IGGEEEKVEY EPTKIMGSYQ DGKISLHPMV ISAHTNRVAV
VDAHTICLSF STNQKVSKDN IISVLKNYQM PEICIGLPSC PDRGIVYHEA DNRPQPRLDR
NLGRGMSTSV GRIREDSIFD FRMVSLSHNT IMGAAGGSIF NGELLARRKF GF
//
