ID A0A0S7CYT0_9MICC Unreviewed; 285 AA.
AC A0A0S7CYT0;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=argininosuccinate lyase {ECO:0000256|ARBA:ARBA00012338};
DE EC=4.3.2.1 {ECO:0000256|ARBA:ARBA00012338};
GN ORFNames=AHiyo1_10350 {ECO:0000313|EMBL:GAP58063.1};
OS Arthrobacter sp. Hiyo1.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC Arthrobacter.
OX NCBI_TaxID=1588020 {ECO:0000313|EMBL:GAP58063.1};
RN [1] {ECO:0000313|EMBL:GAP58063.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hiyo1 {ECO:0000313|EMBL:GAP58063.1};
RX PubMed=26764021; DOI=10.1186/s12864-016-2380-4;
RA Hiraoka S., Machiyama A., Ijichi M., Inoue K., Oshima K., Hattori M.,
RA Yoshizawa S., Kogure K., Iwasaki W.;
RT "Genomic and metagenomic analysis of microbes in a soil environment
RT affected by the 2011 Great East Japan Earthquake tsunami.";
RL BMC Genomics 17:53-53(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-(N(omega)-L-arginino)succinate = fumarate + L-arginine;
CC Xref=Rhea:RHEA:24020, ChEBI:CHEBI:29806, ChEBI:CHEBI:32682,
CC ChEBI:CHEBI:57472; EC=4.3.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000985};
CC -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine
CC from L-ornithine and carbamoyl phosphate: step 3/3.
CC {ECO:0000256|ARBA:ARBA00004941}.
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DR EMBL; DF952469; GAP58063.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0S7CYT0; -.
DR UniPathway; UPA00068; UER00114.
DR Proteomes; UP000063628; Unassembled WGS sequence.
DR GO; GO:0004056; F:argininosuccinate lyase activity; IEA:UniProtKB-EC.
DR GO; GO:0042450; P:arginine biosynthetic process via ornithine; IEA:InterPro.
DR CDD; cd01359; Argininosuccinate_lyase; 1.
DR Gene3D; 1.10.40.30; Fumarase/aspartase (C-terminal domain); 1.
DR Gene3D; 1.20.200.10; Fumarase/aspartase (Central domain); 1.
DR Gene3D; 1.10.275.10; Fumarase/aspartase (N-terminal domain); 1.
DR InterPro; IPR029419; Arg_succ_lyase_C.
DR InterPro; IPR009049; Argininosuccinate_lyase.
DR InterPro; IPR024083; Fumarase/histidase_N.
DR InterPro; IPR020557; Fumarate_lyase_CS.
DR InterPro; IPR000362; Fumarate_lyase_fam.
DR InterPro; IPR022761; Fumarate_lyase_N.
DR InterPro; IPR008948; L-Aspartase-like.
DR NCBIfam; TIGR00838; argH; 1.
DR PANTHER; PTHR43814; ARGININOSUCCINATE LYASE; 1.
DR PANTHER; PTHR43814:SF1; ARGININOSUCCINATE LYASE; 1.
DR Pfam; PF14698; ASL_C2; 1.
DR Pfam; PF00206; Lyase_1; 1.
DR PRINTS; PR00145; ARGSUCLYASE.
DR PRINTS; PR00149; FUMRATELYASE.
DR SUPFAM; SSF48557; L-aspartase-like; 1.
DR PROSITE; PS00163; FUMARATE_LYASES; 1.
PE 4: Predicted;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW Arginine biosynthesis {ECO:0000256|ARBA:ARBA00022571};
KW Lyase {ECO:0000313|EMBL:GAP58063.1}.
FT DOMAIN 2..122
FT /note="Fumarate lyase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00206"
FT DOMAIN 185..253
FT /note="Argininosuccinate lyase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF14698"
SQ SEQUENCE 285 AA; 30605 MW; BD6BC3D6E11DA328 CRC64;
MQRFQDWDKR AGVSPYGSGA LAGSSLGLDP EAVASDLGFF SAVHNSIDGT ASRDVFAEFA
WICSMIGVDL SRVSEEVILW ATKEFSFVTL HDSYSTGSSI MPQKKNPDVA ELARGKAGRL
IGNLTGLLAT LKGLPLAYNR DLQEDKEPVF DAADTLEVLL PAVSGMIATL TFNTERMASL
APQGFALATD IAEWLVRQGV PFREAHELSG AAVKLAEGRS VELWDLTDEE YAGISEHLTP
EVRTVLSTEG SLNSRNSQGG TAPAAVERQL LALEAELAAV RKYAE
//
