ID A0A0S7DL43_9EURO Unreviewed; 631 AA.
AC A0A0S7DL43;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=proline--tRNA ligase {ECO:0000256|ARBA:ARBA00012831};
DE EC=6.1.1.15 {ECO:0000256|ARBA:ARBA00012831};
GN ORFNames=CNMCM8060_000648 {ECO:0000313|EMBL:KAF4173039.1};
OS Aspergillus lentulus.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=293939 {ECO:0000313|EMBL:KAF4173039.1, ECO:0000313|Proteomes:UP000713487};
RN [1] {ECO:0000313|EMBL:KAF4173039.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CNM-CM8060 {ECO:0000313|EMBL:KAF4173039.1};
RA dos Santos R.A.C., Steenwyk J.L., Rivero-Menendez O., Mead M.E.,
RA Silva L.P., Bastos R.W., Alastruey-Izquierdo A., Goldman G.H., Rokas A.;
RT "Genomic and phenotypic heterogeneity of clinical isolates of the human
RT pathogens Aspergillus fumigatus, Aspergillus lentulus and Aspergillus
RT fumigatiaffinis.";
RL bioRxiv 0:0-0(2020).
RN [2] {ECO:0000313|EMBL:KAF4173039.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CNM-CM8060 {ECO:0000313|EMBL:KAF4173039.1};
RA Santos R.A.C., Steenwyk J.L., Rivero-Menendez O., Mead M.E., Silva L.P.,
RA Bastos R.W., Alastruey-Izquierdo A., Goldman G.H., Rokas A.;
RL Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAF4173039.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JAAAPS010000116; KAF4173039.1; -; Genomic_DNA.
DR STRING; 293939.A0A0S7DL43; -.
DR VEuPathDB; FungiDB:TMP_alenIFM54703_3581; -.
DR Proteomes; UP000713487; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004827; F:proline-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0006433; P:prolyl-tRNA aminoacylation; IEA:InterPro.
DR CDD; cd00862; ProRS_anticodon_zinc; 1.
DR CDD; cd00778; ProRS_core_arch_euk; 1.
DR Gene3D; 3.40.50.800; Anticodon-binding domain; 1.
DR Gene3D; 3.30.110.30; C-terminal domain of ProRS; 1.
DR HAMAP; MF_01571; Pro_tRNA_synth_type3; 1.
DR InterPro; IPR002314; aa-tRNA-synt_IIb.
DR InterPro; IPR006195; aa-tRNA-synth_II.
DR InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR InterPro; IPR004154; Anticodon-bd.
DR InterPro; IPR036621; Anticodon-bd_dom_sf.
DR InterPro; IPR004499; Pro-tRNA-ligase_IIa_arc-type.
DR InterPro; IPR016061; Pro-tRNA_ligase_II_C.
DR InterPro; IPR017449; Pro-tRNA_synth_II.
DR InterPro; IPR033721; ProRS_core_arch_euk.
DR NCBIfam; TIGR00408; proS_fam_I; 1.
DR PANTHER; PTHR43382:SF2; BIFUNCTIONAL GLUTAMATE_PROLINE--TRNA LIGASE; 1.
DR PANTHER; PTHR43382; PROLYL-TRNA SYNTHETASE; 1.
DR Pfam; PF03129; HGTP_anticodon; 1.
DR Pfam; PF09180; ProRS-C_1; 1.
DR Pfam; PF00587; tRNA-synt_2b; 1.
DR SMART; SM00946; ProRS-C_1; 1.
DR SUPFAM; SSF64586; C-terminal domain of ProRS; 1.
DR SUPFAM; SSF52954; Class II aaRS ABD-related; 1.
DR SUPFAM; SSF55681; Class II aaRS and biotin synthetases; 1.
DR PROSITE; PS50862; AA_TRNA_LIGASE_II; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
SQ SEQUENCE 631 AA; 70593 MW; 5E8FD9E453A9454A CRC64;
MASQNAADIP VATDPVTLPD RSQNPADVDK AAPQGETSKN AAKKAAKLAK QAAEKAEKAA
NKGIGKSEAK KATSKAPKKK IEGAALIGID VSKEEDFSGW YQQVLTKGDM LDYYDVSGCF
ILKPASYFIW EEIQNWFNAE IKKVGVKNCS FPLFVSEDVL QREKDHIEGF AAEVAWVTHA
YDFPFDQRGN TPLEKKIAIR PTSETVMYPY YAKWIRSHRD LPLKLNQWNS VVRWEFKHPQ
PFLRTREFLW QEGHTAHLTE EAAREEVLHM LDLYARIYEE LLAVPVVKGQ KTEKEKFAGG
LYTTTVEGYI PATGRGIQGG TSHGLGQNFS KMFGITVEDP SAKPDEKKAP LYVWQNSWGL
STRTLGVMVM IHSDNRGLVL PPRVAETQTI IVPVGITAKT SDEEREKLYA EIDSLVSLLK
AAGIRADSDK REGYSPGWKF NDWELRGVPL RIEFGPGESA GRYVTAARRD IPGKDGKSTI
PIDELSTAVP ALLETIHKDL YKRADNEFRA HRKLITNWDD FTPALNEKNI CVIPHCLTEE
CEDQIKELSA RKAEEDSGVP QDARAPSMGA KSLCIPFDQP EGIVHGQTKC VNPKCTRMAE
KWCMFGRKFP SYAFALEGIE QFTDDLRAGS Y
//
