ID   A0A0S7ZFW7_9SPIR        Unreviewed;       449 AA.
AC   A0A0S7ZFW7;
DT   17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT   17-FEB-2016, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Malate dehydrogenase {ECO:0000313|EMBL:KPJ85954.1};
GN   ORFNames=AMS17_13790 {ECO:0000313|EMBL:KPJ85954.1};
OS   Spirochaetes bacterium DG_61.
OC   Bacteria; Spirochaetota.
OX   NCBI_TaxID=1704237 {ECO:0000313|EMBL:KPJ85954.1, ECO:0000313|Proteomes:UP000050987};
RN   [1] {ECO:0000313|EMBL:KPJ85954.1, ECO:0000313|Proteomes:UP000050987}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DG_61 {ECO:0000313|EMBL:KPJ85954.1};
RX   PubMed=25922666; DOI=10.1186/s40168-015-0077-6;
RA   Baker B.J., Lazar C.S., Teske A.P., Dick G.J.;
RT   "Genomic resolution of linkages in carbon, nitrogen, and sulfur cycling
RT   among widespread estuary sediment bacteria.";
RL   Microbiome 3:14-14(2015).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KPJ85954.1}.
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DR   EMBL; LJNB01000210; KPJ85954.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0S7ZFW7; -.
DR   PATRIC; fig|1704237.3.peg.1302; -.
DR   Proteomes; UP000050987; Unassembled WGS sequence.
DR   GO; GO:0004470; F:malic enzyme activity; IEA:InterPro.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   CDD; cd05311; NAD_bind_2_malic_enz; 1.
DR   Gene3D; 3.40.50.10380; Malic enzyme, N-terminal domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR   InterPro; IPR012301; Malic_N_dom.
DR   InterPro; IPR037062; Malic_N_dom_sf.
DR   InterPro; IPR012302; Malic_NAD-bd.
DR   InterPro; IPR045213; Malic_NAD-bd_bact_type.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43237; NADP-DEPENDENT MALIC ENZYME; 1.
DR   PANTHER; PTHR43237:SF4; NADP-DEPENDENT MALIC ENZYME; 1.
DR   Pfam; PF00390; malic; 1.
DR   Pfam; PF03949; Malic_M; 1.
DR   SMART; SM01274; malic; 1.
DR   SMART; SM00919; Malic_M; 1.
DR   SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
FT   DOMAIN          27..160
FT                   /note="Malic enzyme N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM01274"
FT   DOMAIN          172..404
FT                   /note="Malic enzyme NAD-binding"
FT                   /evidence="ECO:0000259|SMART:SM00919"
SQ   SEQUENCE   449 AA;  49541 MW;  AEAB9CAF4D341C1B CRC64;
     MEQDEKKLLA KANKPLEVAS ALHRHYRGKI SVAPRCRIKD LHDFDVWYTP GVSSPCREIN
     KNPELAYEYT CKWNTVAVIS DGTRVLGLGD IGPEAAIPVM EGKALLYKYL GGVDSYPICL
     DTKNPELFID TVKLLQPALG GVNLEDIEQP KCFYILERLR KECRIPVWHD DQQGTAAVTL
     AGLINALKFV GKDIGKVKIV FLGAGAANIR TSDMIFQAGA DPGRCIMYDS KGSLSKKRHD
     LEQKPEFEEK WKVCGMTNEA RFEGPVWEAL KGADAFIALS KPGPGTVKKD WISAMGKDPI
     VFVCANPVPE IWPWEAKAAG ACIVATGRSD FPNQVNNSLG FPGIFRGTLD VRASTITDEM
     CIAAAMELAN TAEDNGLKED YIIPTMEEWE VFPREAAAVG MKAIEQGIAK KVMSRDELYT
     TAEAIIRDAR EAVKILMREG VIKGIDKEF
//