ID   A0A0S8CPY1_9BACT        Unreviewed;      1143 AA.
AC   A0A0S8CPY1;
DT   17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT   17-FEB-2016, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=Guanylate cyclase domain-containing protein {ECO:0000259|PROSITE:PS50125};
GN   ORFNames=AMK69_14950 {ECO:0000313|EMBL:KPK25179.1};
OS   Nitrospira bacterium SG8_3.
OC   Bacteria; Nitrospirota; Nitrospiria.
OX   NCBI_TaxID=1704023 {ECO:0000313|EMBL:KPK25179.1, ECO:0000313|Proteomes:UP000051394};
RN   [1] {ECO:0000313|EMBL:KPK25179.1, ECO:0000313|Proteomes:UP000051394}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SG8_3 {ECO:0000313|EMBL:KPK25179.1};
RX   PubMed=25922666; DOI=10.1186/s40168-015-0077-6;
RA   Baker B.J., Lazar C.S., Teske A.P., Dick G.J.;
RT   "Genomic resolution of linkages in carbon, nitrogen, and sulfur cycling
RT   among widespread estuary sediment bacteria.";
RL   Microbiome 3:14-14(2015).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KPK25179.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; LJNR01000272; KPK25179.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0S8CPY1; -.
DR   PATRIC; fig|1704023.3.peg.1495; -.
DR   Proteomes; UP000051394; Unassembled WGS sequence.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR041664; AAA_16.
DR   InterPro; IPR025874; DZR.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR16305:SF28; ADENYLATE CYCLASE 10; 1.
DR   PANTHER; PTHR16305; TESTICULAR SOLUBLE ADENYLYL CYCLASE; 1.
DR   Pfam; PF13191; AAA_16; 1.
DR   Pfam; PF12773; DZR; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF81901; HCP-like; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF48452; TPR-like; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          106..240
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   1143 AA;  129336 MW;  120BFBD8A2143C5C CRC64;
     MSRAIWRAFI LKCPRCQFEN PEGIKFCGEC GTKLERVCTH CHFSNPPQFK FCGDCGHKLT
     IPAEPSPREL SFDEKISKIQ RYLPKGLTEK ILSQKNKIEG ERKQVTVLFC DMEGFTPLVE
     KIGPDEAYDI MDQVYELLIH KVNDYEGTVN EMTGDGIMAL FGAPIALEDA PQRAIRSAHG
     IHQEMTKFNQ RLREQKKKIP TLKMRIGIHS GPVVVGTLGN DLRVEFKAVG DTVNLASRME
     GMAEPGTSNV TEETFKLTED LFRFESLGEK KVKGKEKSVK VYRVIAPSNM RTRFDVSAER
     GLTKFVGRSR ELDLLLDGFE RSKSGRGQVF SIIAEAGVGK SRLLYEFRKA IASEDATFLE
     GLCLSYGRNM AYRPVIDILR ANFNIKEGEG DNKIKEKIER DLKVLGLDES SIRPYLLELF
     SVKDRGISET LMSPEMRKDL IIEAIKRITL AGAETRTIVI AVEDLHWIDE SSEELFKDIL
     DSISGARVFL IMTYRPEFVP IWSGKSYHNQ VNLNRLSNRE SLAMVFDLLG AEEVSEDLEE
     LILNKAEGIP FFIEEFVKSI RDLGLLKKTN GTCRLAKDLQ ELTVPVNVQD MIMARIDSLH
     ESAKELLRTG SVIGREFSHE LIRAVAGLPE QELLTHLSVL KDSELVYERG IYPDSSYVFQ
     HALTQEVGYG SLLSNKKNEL HASIGQAFEE IHRDRIEEFY EMLAHHYSKS DDTEKALEYL
     FKAGEKAKRT YANDAAIAFL TQGLELLKSL PETHERAKQE LDFQIALGVP LIAIKGNGAQ
     EVETTYARAR DLCEQIADDS QLFQVLVGLR RVFFARGELL RAHELGEHLH RLSRGMENSA
     HLSRALMLLA ETLYCLGKFA RVREQCQQVI RLCDTERRQS QVRLYGTDAL CACRIIEACA
     LWYLGYPDQA VKKSNDGLAR AQELSHPFNL AHSISFNATV HQLRRDVQAV LEKAEALIQF
     ATEQRFPLWK AWGMLLQGWA LVEQGNRNEG IAQLRQALED YSSMELLFFP TYSFALLAEA
     YGKMGHVKDG LIVLGEALEK AHKGGERLHE AELYRIKGEL LLIRGGAESK CEACFHQAIG
     VARDQNAKAL ELRAAMSLSR LYQKQGRKED ARTLLEDIYG WFTEGFETAD LKEARALFEE
     LSD
//