ID A0A0S8DQG8_9BACT Unreviewed; 1027 AA.
AC A0A0S8DQG8;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Mechanosensitive ion channel inner membrane domain-containing protein {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=AMJ65_13350 {ECO:0000313|EMBL:KPK38098.1};
OS Phycisphaerae bacterium SG8_4.
OC Bacteria; Planctomycetota; Phycisphaerae.
OX NCBI_TaxID=1703409 {ECO:0000313|EMBL:KPK38098.1, ECO:0000313|Proteomes:UP000051853};
RN [1] {ECO:0000313|EMBL:KPK38098.1, ECO:0000313|Proteomes:UP000051853}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SG8_4 {ECO:0000313|EMBL:KPK38098.1};
RX PubMed=25922666; DOI=10.1186/s40168-015-0077-6;
RA Baker B.J., Lazar C.S., Teske A.P., Dick G.J.;
RT "Genomic resolution of linkages in carbon, nitrogen, and sulfur cycling
RT among widespread estuary sediment bacteria.";
RL Microbiome 3:14-14(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MscS (TC 1.A.23) family.
CC {ECO:0000256|ARBA:ARBA00008017}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPK38098.1}.
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DR EMBL; LJTR01000261; KPK38098.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0S8DQG8; -.
DR Proteomes; UP000051853; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.10.287.1260; -; 1.
DR Gene3D; 2.30.30.60; -; 1.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR049142; MS_channel_1st.
DR InterPro; IPR023408; MscS_beta-dom_sf.
DR InterPro; IPR006685; MscS_channel_2nd.
DR InterPro; IPR011014; MscS_channel_TM-2.
DR InterPro; IPR025692; MscS_IM_dom1.
DR InterPro; IPR024393; MscS_porin.
DR PANTHER; PTHR30347:SF1; MINICONDUCTANCE MECHANOSENSITIVE CHANNEL MSCM; 1.
DR PANTHER; PTHR30347; POTASSIUM CHANNEL RELATED; 1.
DR Pfam; PF21088; MS_channel_1st; 1.
DR Pfam; PF00924; MS_channel_2nd; 1.
DR Pfam; PF12795; MscS_porin; 1.
DR Pfam; PF12794; MscS_TM; 1.
DR SUPFAM; SSF82861; Mechanosensitive channel protein MscS (YggB), transmembrane region; 1.
DR SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 536..556
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 577..598
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 610..634
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 654..673
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 693..712
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 733..753
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 765..787
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 841..858
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 878..900
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 921..943
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 955..983
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 76..306
FT /note="Mechanosensitive ion channel MscS porin"
FT /evidence="ECO:0000259|Pfam:PF12795"
FT DOMAIN 536..874
FT /note="Mechanosensitive ion channel inner membrane"
FT /evidence="ECO:0000259|Pfam:PF12794"
FT DOMAIN 928..969
FT /note="Mechanosensitive ion channel transmembrane helices
FT 2/3"
FT /evidence="ECO:0000259|Pfam:PF21088"
FT DOMAIN 971..1027
FT /note="Mechanosensitive ion channel MscS"
FT /evidence="ECO:0000259|Pfam:PF00924"
FT REGION 28..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 806..827
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 149..176
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1027
FT /evidence="ECO:0000313|EMBL:KPK38098.1"
SQ SEQUENCE 1027 AA; 114284 MW; 8FE4314282C3660D CRC64;
MNRKFGVSAV LFTAFLVLTS SILLSGQSRP DAAPSASESQ DVNLPGSGAT VMQSPATADA
GVALTVEQLQ TQKKQIAQSQ ELSEDVKAKI VEIYDRALAQ LKSAGEFEVK RQQYGQQRKN
APDNLEKTKE LLGAKGAPAA PQVAAGTTLT EAEQALAAAR LALEEARKNV ANWESEPKTR
ADRRTRIPEE LNTLRQKLEE TKAKLALPPA EGQSNELAQA NRILLLAQQR ALENQIAANT
EELLSYDAGS ELLAAQRDLA ARRQSSAENV VEFWQQKVGD LRQKQAEAAK SEAIRAREET
THPAIQAIAE KNAELAETQA SLANKVQTVA KYSEEIEAKL ETVKKSFAET RARVDTAGQV
TDVMGMFLLG EREKLPSIGP NERQIRNRPS EISLAQFRWM ERDREWSDLG DLADELDAIL
AGLDPNVAES QRQAIEKEAI NSYDSQRKLL RATADLYGDY STKLANLDAT ERQYVETVRS
YADFIDASIL WVKSSPALRL SDLPTNISAV RWLLSPANWR RSALALWADF QKNVSLYLAA
LLVIVSLVVL HPRAHAGVEA LSEKVRQVQT DSFGHTLKAL GLTIFLAATW PAILLVIQNR
LSAAAGDHDF SQALATSLLG LVPIVFALCF LRHFAMPRGL AQDHLRMRQE PLSFFRRVLG
WYLLLTVPIT LIVQLMQNQQ TSEQWYNSAG RLFFMAGLIV LSLLLLLLLR PTGTLMEPYL
RQRRGSWLER LRYLWYPLCF VLPAAFAVLA GLGDFYAARH LYEKLVVTMV LILLTILVRA
MFVRWLMVAQ RRLALLERQK REAAELAEGQ SESAPAAEPT QGKAKDDETT IFQISRQTRR
LIDVTTLLFP AAGIWYVWND VLPALNALAE RRLWRMDAET PVTVGSVATA LVIVALTVIV
TRNAPGLLEI IILRRLPLDR GIRFAITTIF RYILVVVGTV LAFTEIGIGW SKVQWLIAAM
TVGLGFGLQE IFANFVSGLI ILFEQPIRVD DVVTIGEVTG NVSKIRIRAT TIRRWDQREL
VVPNKEF
//
