ID A0A0T6B8Z1_9SCAR Unreviewed; 643 AA.
AC A0A0T6B8Z1;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=FERM, RhoGEF and pleckstrin domain-containing protein 2 {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=AMK59_4306 {ECO:0000313|EMBL:KRT83809.1};
OS Oryctes borbonicus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Scarabaeiformia;
OC Scarabaeidae; Dynastinae; Oryctes.
OX NCBI_TaxID=1629725 {ECO:0000313|EMBL:KRT83809.1, ECO:0000313|Proteomes:UP000051574};
RN [1] {ECO:0000313|EMBL:KRT83809.1, ECO:0000313|Proteomes:UP000051574}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OB123 {ECO:0000313|EMBL:KRT83809.1};
RC TISSUE=Whole animal {ECO:0000313|EMBL:KRT83809.1};
RA Meyer J.M., Markov G.V., Baskaran P., Herrmann M., Sommer R.J.,
RA Roedelsperger C.;
RT "Draft genome of the scarab beetle Oryctes borbonicus.";
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRT83809.1}.
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DR EMBL; LJIG01009073; KRT83809.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0T6B8Z1; -.
DR OrthoDB; 2876516at2759; -.
DR Proteomes; UP000051574; Unassembled WGS sequence.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd13193; FERM_C_FARP1-like; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR014847; FA.
DR InterPro; IPR041788; FARP1/FARP2/FRMD7_FERM_C.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR45858; FERM DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45858:SF5; MOESIN_EZRIN_RADIXIN HOMOLOG 1; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000051574}.
FT DOMAIN 1..115
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 403..591
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 236..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 238..287
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KRT83809.1"
SQ SEQUENCE 643 AA; 72359 MW; 02064E1A45B92EEC CRC64;
QSPAEADLNL LETARRCELY GMKMHPAKDH ENVPLNLAVA HMGIVVFQQY TKINTFSWAK
IRKISFKRKR FLIKLHPEGY GYYKDTVEFF FEGRNECKNF WKKCVENHGF FRCSSVKNVS
RHKTRVLSRG SSFRYSGRTQ KQIIEFVRDN YVKRQAFQRS ASFRHSSAHS SATNMHNSSV
GNSISAHPLL PLADSNLSVE VSKLSASLGS MGVVDQDSLT TKSAFHPHGI AISWSSAPDT
RPIIQPAQTM SSPSPPLTTQ SASPVTSATT SPQHIPYEST RQLPPVQSLP PSSSPVAVRA
AVHRADTAVA ATADMAKETV NNAYENNNSF YTTSPQKING SISGYSLATT NLYKQTNSED
ISVITNAAKE EYMNSVNSNI TPNTTTIIAD IEGEVRKKPK NERTYYIAKE LLMTEITYKK
DLDVINVWFK EEVGKDNVDD CSIKVLLDLI TPLADAHGFL VKDLEHRLQN WDGSGPNAKV
GQIVDVLLTH LPPLIPIYEE YLDGHVLVLE KLDMAFKQNG LFEQIYRDFE SQKVCYLPLT
TFVLKPLHRL LQYQAILQRL LLHYEPNHPD RADCLTASDT LKDLMLPVSE TLACSENLAT
LCELQRDIVG FDNLVQPGRT FIRHGCLLKH SRKGYQQRMF FLV
//
