ID A0A0U1NPQ3_9RHOB Unreviewed; 423 AA.
AC A0A0U1NPQ3;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN Name=dinB_3 {ECO:0000313|EMBL:CRK76676.1};
GN ORFNames=NIG5292_02741 {ECO:0000313|EMBL:CRK76676.1};
OS Nereida ignava.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Nereida.
OX NCBI_TaxID=282199 {ECO:0000313|EMBL:CRK76676.1, ECO:0000313|Proteomes:UP000048949};
RN [1] {ECO:0000313|EMBL:CRK76676.1, ECO:0000313|Proteomes:UP000048949}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CECT 5292 {ECO:0000313|EMBL:CRK76676.1,
RC ECO:0000313|Proteomes:UP000048949};
RA Syromyatnikov M.Y., Popov V.N.;
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Poorly processive, error-prone DNA polymerase involved in
CC untargeted mutagenesis. Copies undamaged DNA at stalled replication
CC forks, which arise in vivo from mismatched or misaligned primer ends.
CC These misaligned primers can be extended by PolIV. Exhibits no 3'-5'
CC exonuclease (proofreading) activity. May be involved in translesional
CC synthesis, in conjunction with the beta clamp from PolIII.
CC {ECO:0000256|ARBA:ARBA00025589}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SUBUNIT: Monomer. {ECO:0000256|ARBA:ARBA00011245}.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-Y family.
CC {ECO:0000256|ARBA:ARBA00010945}.
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DR EMBL; CVQV01000029; CRK76676.1; -; Genomic_DNA.
DR RefSeq; WP_048600072.1; NZ_CVQV01000029.1.
DR AlphaFoldDB; A0A0U1NPQ3; -.
DR STRING; 282199.GCA_001049735_02740; -.
DR OrthoDB; 9808813at2; -.
DR Proteomes; UP000048949; Unassembled WGS sequence.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-KW.
DR CDD; cd01700; PolY_Pol_V_umuC; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.40.1170.60; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR017961; DNA_pol_Y-fam_little_finger.
DR InterPro; IPR025188; DUF4113.
DR InterPro; IPR024728; PolY_HhH_motif.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001126; UmuC.
DR PANTHER; PTHR11076; DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER; 1.
DR PANTHER; PTHR11076:SF34; PROTEIN UMUC; 1.
DR Pfam; PF13438; DUF4113; 1.
DR Pfam; PF00817; IMS; 1.
DR Pfam; PF11799; IMS_C; 1.
DR Pfam; PF11798; IMS_HHH; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50173; UMUC; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00023199};
KW Nucleotidyltransferase {ECO:0000313|EMBL:CRK76676.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000048949};
KW SOS mutagenesis {ECO:0000256|ARBA:ARBA00023199};
KW SOS response {ECO:0000256|ARBA:ARBA00023236};
KW Transferase {ECO:0000313|EMBL:CRK76676.1}.
FT DOMAIN 5..187
FT /note="UmuC"
FT /evidence="ECO:0000259|PROSITE:PS50173"
SQ SEQUENCE 423 AA; 47145 MW; 7E242B7B1F0F37B3 CRC64;
MKTPIAISDS ANFYVSAERL FEPGLKNTPV IVLSNNDGCA VARSDEAKAL GIKMGAPLHK
LKDVITKHGV CVFSSNYTLY GDISRRVVEV YQEFSPTVEV YSIDECFMDL GGFKDREAHA
QKLRKAVLHK VGIPVRVGIA STKTLAKCAN DIAKKNALFD GVLDMMDEQL IDWLLPKVPV
SDIWGIGRKT NKKLGRLGIY TAADLQRMPI KQARSVGTVV LEKTVLELQG EPCLALDEVE
PQRKGMAVTR SAGMPMFGFD VLFEAITAHT TRAAEKLRQN ELAAGTLTVF FHTNRHRPDR
PQYASSRSIQ LSPMSCDTFE LVRAARKCAI AAWPKANSNQ YGFTKAGVML DDLIPIEQRP
LTLFDVPEKQ TKPAVEALDQ INRQFEIKTI TLGSEGVERL WRMRSIHRSP RYTTRLSDLP
IVR
//
