ID A0A0U2QRP6_9ALTE Unreviewed; 502 AA.
AC A0A0U2QRP6;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Tryptophan halogenase {ECO:0000313|EMBL:ALT00540.1};
GN ORFNames=AT746_17600 {ECO:0000313|EMBL:ALT00540.1};
OS Lacimicrobium alkaliphilum.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Alteromonadaceae; Lacimicrobium.
OX NCBI_TaxID=1526571 {ECO:0000313|EMBL:ALT00540.1, ECO:0000313|Proteomes:UP000068447};
RN [1] {ECO:0000313|EMBL:ALT00540.1, ECO:0000313|Proteomes:UP000068447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YelD216 {ECO:0000313|EMBL:ALT00540.1,
RC ECO:0000313|Proteomes:UP000068447};
RA Kim S.-G., Lee Y.-J.;
RT "Complete genome of Lacimicrobium alkaliphilum KCTC 32984.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP013650; ALT00540.1; -; Genomic_DNA.
DR RefSeq; WP_062484375.1; NZ_CP013650.1.
DR AlphaFoldDB; A0A0U2QRP6; -.
DR STRING; 1526571.AT746_17600; -.
DR KEGG; lal:AT746_17600; -.
DR OrthoDB; 7178350at2; -.
DR Proteomes; UP000068447; Chromosome.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006905; Flavin_halogenase.
DR InterPro; IPR033856; Trp_halogen.
DR PANTHER; PTHR43747; FAD-BINDING PROTEIN; 1.
DR PANTHER; PTHR43747:SF4; FLAVIN-DEPENDENT TRYPTOPHAN HALOGENASE; 1.
DR Pfam; PF04820; Trp_halogenase; 1.
DR PIRSF; PIRSF011396; Trp_halogenase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|PIRSR:PIRSR011396-2};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR011396-2};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR011396-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000068447}.
FT ACT_SITE 79
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-1"
FT BINDING 13..16
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 79
FT /ligand="7-chloro-L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:58713"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 186
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 333
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 342
FT /ligand="L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:57912"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
SQ SEQUENCE 502 AA; 57850 MW; F722301CCCFBF47A CRC64;
MTEKLRKIIV LGGGSAGWMT AAALGKVLKN QYCQIQVIES EQIGTVGVGE ATIPQIMLYN
QLIGLDEDEF VRRTQGTFKL GIQFVDWHKP GSSYFHAFGD VGKNMEGVQF YHYWLKLRAL
GKAAPLDDYT LTSLACHEKR FMRSIDAGNS PLSNIAYAFH FDAGLFAKYL RELSQGWGVQ
RTEGKVVEVR QHDNGFIHSL LLEDGSEHEA DFFIDCSGFR GLLIEQTLKT GFEDWSHWLP
CDNAIAVPSA NTKEPWPFTR ASAQKAGWQW RIPLQHRVGN GHVYCSQFMS EDEATHILLK
NLDGEPLAEP RRIRFKTGKR KQFWNKNCLA VGLAGGFMEP LESTSLHMVQ AAISKLFSFF
PDRQFAQADI DEFNRQMHFD YDRIRDFLIL HYYATQRDDS PFWDYCRTMD VPEELTQKIE
QFRSNGRVFR FNNEMFSDLS WFEVMLGQGI EPRGYHPLAD IFSEQELARR LESIRGVIRK
SVDYMPSHQE FIDQHCKARK VY
//
