ID A0A0U3G3W1_9MICC Unreviewed; 323 AA.
AC A0A0U3G3W1;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Thioredoxin reductase {ECO:0000313|EMBL:ALU39610.1};
GN ORFNames=AS188_07430 {ECO:0000313|EMBL:ALU39610.1}, KFL01_07010
GN {ECO:0000313|EMBL:GEO91395.1};
OS Kocuria flava.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC Kocuria.
OX NCBI_TaxID=446860 {ECO:0000313|EMBL:ALU39610.1, ECO:0000313|Proteomes:UP000057181};
RN [1] {ECO:0000313|EMBL:ALU39610.1, ECO:0000313|Proteomes:UP000057181}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HO-9041 {ECO:0000313|EMBL:ALU39610.1,
RC ECO:0000313|Proteomes:UP000057181};
RA Zhou M., Dai J.;
RT "Complete Genome Sequence of Kocuria flava strain HO-9041.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:GEO91395.1, ECO:0000313|Proteomes:UP000321155}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 107626 {ECO:0000313|EMBL:GEO91395.1,
RC ECO:0000313|Proteomes:UP000321155};
RA Hosoyama A., Uohara A., Ohji S., Ichikawa N.;
RT "Whole genome shotgun sequence of Kocuria flava NBRC 107626.";
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide +
CC H(+) + NADPH; Xref=Rhea:RHEA:20345, Rhea:RHEA-COMP:10698, Rhea:RHEA-
CC COMP:10700, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058,
CC ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.8.1.9;
CC Evidence={ECO:0000256|ARBA:ARBA00000849};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
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DR EMBL; CP013254; ALU39610.1; -; Genomic_DNA.
DR EMBL; BJZR01000011; GEO91395.1; -; Genomic_DNA.
DR RefSeq; WP_058858321.1; NZ_CP013254.1.
DR AlphaFoldDB; A0A0U3G3W1; -.
DR STRING; 446860.AS188_07430; -.
DR KEGG; kfv:AS188_07430; -.
DR OrthoDB; 9786503at2; -.
DR Proteomes; UP000057181; Chromosome.
DR Proteomes; UP000321155; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR023753; FAD/NAD-binding_dom.
DR PANTHER; PTHR48105; THIOREDOXIN REDUCTASE 1-RELATED-RELATED; 1.
DR PANTHER; PTHR48105:SF28; THIOREDOXIN REDUCTASE GLIT (AFU_ORTHOLOGUE AFUA_6G09740); 1.
DR Pfam; PF07992; Pyr_redox_2; 1.
DR PRINTS; PR00368; FADPNR.
DR PRINTS; PR00469; PNDRDTASEII.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000057181}.
FT DOMAIN 11..289
FT /note="FAD/NAD(P)-binding"
FT /evidence="ECO:0000259|Pfam:PF07992"
SQ SEQUENCE 323 AA; 32833 MW; A5FEE5FE49224264 CRC64;
MTRQTRPETC DVVVVGGGAA GLSAAVALAR SLRSVVVVDA GEPRNAPAAG AHNVLGREGV
APLELLAAGR AEAEGYGARV RADRAVAVRR ADDDGFAVEL AGGAVLRARR LLLATGLVDE
LPELPGLRPY WGTGVLHCPY CHGWEVRGRR IVVLGSSPNS VHQALLFRQL SEDVALVRHT
MPDPGPEAAE QLAAAGIAVV EATAAGVRGA DGVLRALVLS DGTELAADAV VVAPRFAART
GLYEQLGGTP TDHPFGAYVA GDPTGRTEIP GVWVAGNAAD LSAMVSVAGG AGVLAGAAIN
ADLVREDVEA AVRARSAAPA RTG
//
