ID   A0A0U4AGP0_9BACT        Unreviewed;       691 AA.
AC   A0A0U4AGP0;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   SubName: Full=Tungsten formylmethanofuran dehydrogenase {ECO:0000313|EMBL:ALW87372.1};
GN   ORFNames=AUC43_14305 {ECO:0000313|EMBL:ALW87372.1};
OS   Hymenobacter sedentarius.
OC   Bacteria; Bacteroidota; Cytophagia; Cytophagales; Hymenobacteraceae;
OC   Hymenobacter.
OX   NCBI_TaxID=1411621 {ECO:0000313|EMBL:ALW87372.1, ECO:0000313|Proteomes:UP000059542};
RN   [1] {ECO:0000313|EMBL:ALW87372.1, ECO:0000313|Proteomes:UP000059542}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DG5B {ECO:0000313|EMBL:ALW87372.1,
RC   ECO:0000313|Proteomes:UP000059542};
RA   Shamseldin A., Moawad H., Abd El-Rahim W.M., Sadowsky M.J.;
RL   Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
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DR   EMBL; CP013909; ALW87372.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0U4AGP0; -.
DR   STRING; 1411621.AUC43_14305; -.
DR   KEGG; hyg:AUC43_14305; -.
DR   Proteomes; UP000059542; Chromosome.
DR   GO; GO:0016624; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; IEA:InterPro.
DR   CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR   CDD; cd07036; TPP_PYR_E1-PDHc-beta_like; 1.
DR   Gene3D; 3.40.50.920; -; 1.
DR   Gene3D; 3.40.50.970; -; 2.
DR   InterPro; IPR001017; DH_E1.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR009014; Transketo_C/PFOR_II.
DR   InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR   InterPro; IPR033248; Transketolase_C.
DR   PANTHER; PTHR42980:SF1; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR42980; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED; 1.
DR   Pfam; PF00676; E1_dh; 1.
DR   Pfam; PF02779; Transket_pyr; 1.
DR   Pfam; PF02780; Transketolase_C; 1.
DR   SMART; SM00861; Transket_pyr; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR   SUPFAM; SSF52922; TK C-terminal domain-like; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000059542}.
FT   DOMAIN          355..531
FT                   /note="Transketolase-like pyrimidine-binding"
FT                   /evidence="ECO:0000259|SMART:SM00861"
SQ   SEQUENCE   691 AA;  74555 MW;  53F482065F57769A CRC64;
     MDNELLKRAY RLMHTAAAMA TLYEEEKAVA SRYVHATARG HEAVQLAAAF LLLETDYAAP
     YYRDDAMLLG LGLRPYELML QLLAKADDPF SGGRTYYSHP SLRRAGIPVI PHQSSATGMQ
     AIPATGMAHA IHYFEKQGIR IEVPQGLNNP GVEASPLVLC SIGDGAMTEG EVSEALQMAV
     LHQLPIVYLV QDNDWGISAT GREMRAMNAF EFAAGFPGLH RLQVDGADFG SSYQGLAEAF
     AHVRSRRGPV LVHAKCPLLG HHTSGVRREW YRNDLAAHQE QDPLPRLHAR LLQAGFFEAD
     LTALATDAQA TVRADWQAAV AAPNPDPATF ADHEFAPAAV TAEAGERSPA GAEKALMVDA
     ALHAVDDILR EFPEALFYGQ DVGGELGGVF REAALLAKKY GDARVFNTPI QEAYIVGSTA
     GMAAVGARPI VEIQFADYIW PALNQLVEEL SKSCYLTMGK FPVSALIRVP IGAYGGGGPY
     HSGSIESTLL TIRGIKVVYP SNAADMKGLM RAAFLDPNPV VMLEHKGLYW SKVPGTEDAK
     TMEPATGYVI PLGKAAVSQA ADPDKLRQGD TALVVTYGMG VHWAKAASRD FPGQVEILDL
     RTLNPIDFEA VNEATRRHGK VLVLTEEPLL NSFAESLAGR IQRQCFQELD APVFILGAAN
     LPAIALNVEL ERQMLPSAAK VAATLGELLA Y
//