ID A0A0U5KZ89_9GAMM Unreviewed; 347 AA.
AC A0A0U5KZ89;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Ribosomal RNA small subunit methyltransferase C {ECO:0000256|HAMAP-Rule:MF_01862};
DE EC=2.1.1.172 {ECO:0000256|HAMAP-Rule:MF_01862};
DE AltName: Full=16S rRNA m2G1207 methyltransferase {ECO:0000256|HAMAP-Rule:MF_01862};
DE AltName: Full=rRNA (guanine-N(2)-)-methyltransferase RsmC {ECO:0000256|HAMAP-Rule:MF_01862};
GN Name=yjjT {ECO:0000313|EMBL:CUU22863.1};
GN Synonyms=rsmC {ECO:0000256|HAMAP-Rule:MF_01862};
GN ORFNames=EM595_0626 {ECO:0000313|EMBL:CUU22863.1};
OS Duffyella gerundensis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Erwiniaceae; Duffyella.
OX NCBI_TaxID=1619313 {ECO:0000313|EMBL:CUU22863.1, ECO:0000313|Proteomes:UP000059419};
RN [1] {ECO:0000313|Proteomes:UP000059419}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Blom J.;
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Specifically methylates the guanine in position 1207 of 16S
CC rRNA in the 30S particle. {ECO:0000256|HAMAP-Rule:MF_01862}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=guanosine(1207) in 16S rRNA + S-adenosyl-L-methionine = H(+) +
CC N(2)-methylguanosine(1207) in 16S rRNA + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:42736, Rhea:RHEA-COMP:10213, Rhea:RHEA-COMP:10214,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:74269, ChEBI:CHEBI:74481; EC=2.1.1.172;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_01862};
CC -!- SUBUNIT: Monomer. {ECO:0000256|HAMAP-Rule:MF_01862}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01862}.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. RsmC family.
CC {ECO:0000256|HAMAP-Rule:MF_01862}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LN907827; CUU22863.1; -; Genomic_DNA.
DR RefSeq; WP_067427785.1; NZ_LN907827.1.
DR AlphaFoldDB; A0A0U5KZ89; -.
DR STRING; 1619313.EM595_0626; -.
DR KEGG; ege:EM595_0626; -.
DR PATRIC; fig|1619313.3.peg.654; -.
DR OrthoDB; 9816072at2; -.
DR Proteomes; UP000059419; Chromosome 1.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0052914; F:16S rRNA (guanine(1207)-N(2))-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR HAMAP; MF_01862; 16SrRNA_methyltr_C; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR013675; Mtase_sm_N.
DR InterPro; IPR023543; rRNA_ssu_MeTfrase_C.
DR InterPro; IPR046977; RsmC/RlmG.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR007848; Small_mtfrase_dom.
DR PANTHER; PTHR47816; RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE C; 1.
DR PANTHER; PTHR47816:SF4; RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE C; 1.
DR Pfam; PF05175; MTS; 1.
DR Pfam; PF08468; MTS_N; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01862};
KW Methyltransferase {ECO:0000256|HAMAP-Rule:MF_01862,
KW ECO:0000313|EMBL:CUU22863.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000059419};
KW rRNA processing {ECO:0000256|HAMAP-Rule:MF_01862};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691, ECO:0000256|HAMAP-
KW Rule:MF_01862};
KW Transferase {ECO:0000256|HAMAP-Rule:MF_01862, ECO:0000313|EMBL:CUU22863.1}.
FT DOMAIN 8..162
FT /note="Methyltransferase small N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08468"
FT DOMAIN 167..333
FT /note="Methyltransferase small"
FT /evidence="ECO:0000259|Pfam:PF05175"
SQ SEQUENCE 347 AA; 37944 MW; 7DB792BBD765E650 CRC64;
MPAFSPASEV ILRHSDEFTE RRVLFAGDLQ DDLPAQLETQ LSKVFTQQYH HWQLLSPRLE
ENARFSLVAT ADDVSDCDTL VYYWPKSKPE AQYQLQNLLS LLPEGCDLFV IGENRSGVRS
AEGMVEAWAK LDKIDSARRC GLYHGKLETR PDFDAESFWH SYEVDGLTIK TLPGVFSRDG
LDAGSRLLLS TLSAHTKGKV LDVGCGAGVL SATLASHSPK VRLTLTDVNA AAVAASKATL
AANQLEGEVF PSNVFSDVTG RFDMIISNPP FHEGTQTSLD AAQTLIRGAA KHLNTGGELR
IVANAFLPYA QVLDETFGSH EVLAQTGRFK VYRAVYGRAA KALRSAK
//
