ID A0A0V0QRE7_PSEPJ Unreviewed; 986 AA.
AC A0A0V0QRE7;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=p-loop containing nucleoside triphosphate hydrolase {ECO:0000313|EMBL:KRX04592.1};
GN ORFNames=PPERSA_04407 {ECO:0000313|EMBL:KRX04592.1};
OS Pseudocohnilembus persalinus (Ciliate).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Scuticociliatia; Philasterida; Pseudocohnilembidae;
OC Pseudocohnilembus.
OX NCBI_TaxID=266149 {ECO:0000313|EMBL:KRX04592.1, ECO:0000313|Proteomes:UP000054937};
RN [1] {ECO:0000313|EMBL:KRX04592.1, ECO:0000313|Proteomes:UP000054937}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=36N120E {ECO:0000313|EMBL:KRX04592.1};
RX PubMed=26486372; DOI=10.1038/srep15470;
RA Xiong J., Wang G., Cheng J., Tian M., Pan X., Warren A., Jiang C., Yuan D.,
RA Miao W.;
RT "Genome of the facultative scuticociliatosis pathogen Pseudocohnilembus
RT persalinus provides insight into its virulence through horizontal gene
RT transfer.";
RL Sci. Rep. 5:15470-15470(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX04592.1}.
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DR EMBL; LDAU01000114; KRX04592.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0QRE7; -.
DR EnsemblProtists; KRX04592; KRX04592; PPERSA_04407.
DR InParanoid; A0A0V0QRE7; -.
DR OMA; ECEKCIN; -.
DR OrthoDB; 9502at2759; -.
DR Proteomes; UP000054937; Unassembled WGS sequence.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0043139; F:5'-3' DNA helicase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006269; P:DNA replication, synthesis of RNA primer; IEA:UniProtKB-KW.
DR CDD; cd01029; TOPRIM_primases; 1.
DR Gene3D; 3.40.1360.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.90.580.10; Zinc finger, CHC2-type domain; 1.
DR InterPro; IPR007694; DNA_helicase_DnaB-like_C.
DR InterPro; IPR036977; DNA_primase_Znf_CHC2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR034154; TOPRIM_DnaG/twinkle.
DR InterPro; IPR006171; TOPRIM_domain.
DR InterPro; IPR027032; Twinkle-like.
DR PANTHER; PTHR12873; T7-LIKE MITOCHONDRIAL DNA HELICASE; 1.
DR PANTHER; PTHR12873:SF0; TWINKLE MTDNA HELICASE; 1.
DR Pfam; PF13481; AAA_25; 1.
DR Pfam; PF13155; Toprim_2; 1.
DR SMART; SM00493; TOPRIM; 1.
DR SUPFAM; SSF56731; DNA primase core; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF57783; Zinc beta-ribbon; 1.
DR PROSITE; PS51199; SF4_HELICASE; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478};
KW Hydrolase {ECO:0000313|EMBL:KRX04592.1};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Primosome {ECO:0000256|ARBA:ARBA00022515};
KW Reference proteome {ECO:0000313|Proteomes:UP000054937};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 242..321
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
FT DOMAIN 377..623
FT /note="SF4 helicase"
FT /evidence="ECO:0000259|PROSITE:PS51199"
FT REGION 166..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 658..720
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 658..706
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 986 AA; 115203 MW; 6921432AB3FC4F28 CRC64;
MIEQCPFCHK GTDNPSNQYK LEINIDTGLF NCFRCNAKGN WYEFTQLFEG NMDSIDFKRD
IENKANFLSE QDYFLFLRNL LDNDEAFKPA IKYLTKNMQD KNDLECRHLD FDVLKKYKIG
LGFETFQEDT EYYKIPVIYF PMYTRKKKKQ NNNILLQYKI KNFNNQQQDQ SQNENQDEKQ
DENNDNSNNI IDTNYQVNNE HSEIVKCKFR GMSKALKQYQ RMYPSGKIYG IFGLNTVDPN
AQEVIVTEGE FDAMAAYQAT GIPSVSLPNG ANSFPNELIH LFDQFQKIYL WTDSDKQGQE
AVTKISKIFG QERTYIVKPP KEVNNFKIKD ANDALKIYGS NSDEIKSWIK NSKTQILKDV
LSISDLNEQI IQKLFRYNQT LGTPSLSFDS FNKSIKGLRM GELTVLTGLT GVGKTTFLSQ
YSLDFASQGI RTLWGSFEVN TRDLLTIGIQ QFSEENLYKS PENYKKYLDQ FNQLPIRLLD
RYGHQNYIEL CNIIENAIDK EGIKHIILDN LQFLMGTEFN GYQVFIEQDR VIEKLRRIAT
DKNVHITLVI HPKKSNPDED LDIHSFFGNA KCTQEADNVI IIQKRDKYRV LDIKKNRKEG
ELAFQALVLD KTTKRYYEAN HNEILELNKG KIRYEQVVQN GIQKYKDRLK IQLQEYENQN
NGGNSGGPNN DNGNNNFNPG NTNNNGNNSQ GGGGQNIQNY EDLNKDGLNN DNIHNWDDKN
EKNLKINTNK KNEQQYDTYS KLMLDQVKVQ NGNDKKYDYD QTYHLHQFKQ DLQNIDDAQQ
ITDNDLIQLK SQYKDIELFE IQQNSQIIKQ QQNQDSEQQI NQSMQETNYI NQQNYLKQCL
NENDSIDKEV TMDVKNQENI TCLEKYQIQI NSDQINENEN NEFQSESDDE LQISEGLQPL
QKINQIYENG FNFQMNLSKY TSKGEVQDEN LKKAIEFYIL DAQNQKNKKN KNNNYSENSD
FSINDLHYKE YFQQKNQKSK KQKGGI
//
