ID A0A0V0QSX2_PSEPJ Unreviewed; 298 AA.
AC A0A0V0QSX2;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=NADP-dependent oxidoreductase domain {ECO:0000313|EMBL:KRX05348.1};
GN ORFNames=PPERSA_00649 {ECO:0000313|EMBL:KRX05348.1};
OS Pseudocohnilembus persalinus (Ciliate).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Scuticociliatia; Philasterida; Pseudocohnilembidae;
OC Pseudocohnilembus.
OX NCBI_TaxID=266149 {ECO:0000313|EMBL:KRX05348.1, ECO:0000313|Proteomes:UP000054937};
RN [1] {ECO:0000313|EMBL:KRX05348.1, ECO:0000313|Proteomes:UP000054937}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=36N120E {ECO:0000313|EMBL:KRX05348.1};
RX PubMed=26486372; DOI=10.1038/srep15470;
RA Xiong J., Wang G., Cheng J., Tian M., Pan X., Warren A., Jiang C., Yuan D.,
RA Miao W.;
RT "Genome of the facultative scuticociliatosis pathogen Pseudocohnilembus
RT persalinus provides insight into its virulence through horizontal gene
RT transfer.";
RL Sci. Rep. 5:15470-15470(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX05348.1}.
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DR EMBL; LDAU01000109; KRX05348.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0QSX2; -.
DR EnsemblProtists; KRX05348; KRX05348; PPERSA_00649.
DR InParanoid; A0A0V0QSX2; -.
DR OMA; PVCWDPT; -.
DR OrthoDB; 177422at2759; -.
DR Proteomes; UP000054937; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR GO; GO:0044281; P:small molecule metabolic process; IEA:UniProt.
DR CDD; cd19071; AKR_AKR1-5-like; 1.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR018170; Aldo/ket_reductase_CS.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR43827; 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE; 1.
DR PANTHER; PTHR43827:SF3; ALDO-KETO REDUCTASE; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 1.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000054937}.
FT DOMAIN 30..278
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT ACT_SITE 56
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT BINDING 116
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT SITE 85
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ SEQUENCE 298 AA; 34604 MW; 911DFD6CE83591E0 CRC64;
MSQQQTHPCP SISLNSGAQI PACGLGLYKT DLENMQALLQ KALDSGYRHF DTAIHYKNEP
QVGQAFQNIF QKGKYKREDI FITSKVFPRS GWNMVQMAEQ SLKDLQVDYV DLFLLHWPAC
SPSENLEIQH RPVHQVWVEL EECVRKGYVK SIGVSNFNVQ MLFDLLSYAQ IKPSMNQIEL
HLYLQQPKLL KFCEKFNIKI TAFCPLGRGS GMLEDENLKK IAKKYNKTPA QIALHHLHCN
LNAIVIPKTS NLKRLEENFQ WRDFEMDRQD IEYLKNMDKG IRFIDPKNHF TGEIPLFD
//
