ID A0A0V0R2X6_PSEPJ Unreviewed; 3618 AA.
AC A0A0V0R2X6;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 28-JUN-2023, entry version 31.
DE SubName: Full=MIR motif {ECO:0000313|EMBL:KRX08878.1};
GN ORFNames=PPERSA_08982 {ECO:0000313|EMBL:KRX08878.1};
OS Pseudocohnilembus persalinus (Ciliate).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Scuticociliatia; Philasterida; Pseudocohnilembidae;
OC Pseudocohnilembus.
OX NCBI_TaxID=266149 {ECO:0000313|EMBL:KRX08878.1, ECO:0000313|Proteomes:UP000054937};
RN [1] {ECO:0000313|EMBL:KRX08878.1, ECO:0000313|Proteomes:UP000054937}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=36N120E {ECO:0000313|EMBL:KRX08878.1};
RX PubMed=26486372; DOI=10.1038/srep15470;
RA Xiong J., Wang G., Cheng J., Tian M., Pan X., Warren A., Jiang C., Yuan D.,
RA Miao W.;
RT "Genome of the facultative scuticociliatosis pathogen Pseudocohnilembus
RT persalinus provides insight into its virulence through horizontal gene
RT transfer.";
RL Sci. Rep. 5:15470-15470(2015).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00239}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX08878.1}.
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DR EMBL; LDAU01000057; KRX08878.1; -; Genomic_DNA.
DR EnsemblProtists; KRX08878; KRX08878; PPERSA_08982.
DR InParanoid; A0A0V0R2X6; -.
DR OMA; PLFFTFH; -.
DR OrthoDB; 4241306at2759; -.
DR Proteomes; UP000054937; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006816; P:calcium ion transport; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.80.10.50; -; 2.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR014821; Ins145_P3_rcpt.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR036300; MIR_dom_sf.
DR InterPro; IPR016093; MIR_motif.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001300; Peptidase_C2_calpain_cat.
DR InterPro; IPR013662; RIH_assoc-dom.
DR InterPro; IPR015925; Ryanodine_IP3_receptor.
DR InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR PANTHER; PTHR13715:SF99; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR; 1.
DR PANTHER; PTHR13715; RYANODINE RECEPTOR AND IP3 RECEPTOR; 1.
DR Pfam; PF08709; Ins145_P3_rec; 1.
DR Pfam; PF02815; MIR; 1.
DR Pfam; PF00648; Peptidase_C2; 1.
DR Pfam; PF08454; RIH_assoc; 1.
DR SMART; SM00230; CysPc; 1.
DR SMART; SM00368; LRR_RI; 2.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 1.
DR SUPFAM; SSF82109; MIR domain; 2.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50203; CALPAIN_CAT; 1.
DR PROSITE; PS51450; LRR; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054937};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 2458..2476
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2502..2523
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2544..2560
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2566..2591
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2612..2636
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2691..2712
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 3079..3232
FT /note="Calpain catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50203"
FT REGION 285..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 524..555
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1824..1844
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2089..2108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2905..2928
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2861..2888
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3469..3496
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 292..344
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3618 AA; 425537 MW; A6580B9D25906AC9 CRC64;
MSTKQEKQPG IQMVRGPIKY GSIISISHQQ DDLAFLHTYG HINKNLYVRT FRNELQEDQN
KISTNSKKQM MPNISNFTNN QQQQQQNQQI QQQQFYQNKK QKEFNRNKQF TQSLFQVFPR
LTNAQKNEII EKKLDINEDI QEEDQIWEDI INENDIKNKI DEQQIKNLQK KLMSEFKDNY
DTFMKIKGTN ICYNHPIQLL HIESCKFLSC HLQQISKIQS QNYALSLQDY TSEATLFKII
PAFNYQKEGD QVVFSNELIM LIRAIPFHNK TTYLNCSDEV SNLEIKDKSK KQSQNQYPSS
PNSKISQFAN NNNNAQNNQN FNNSNNQNSN QFSQTQLEQD QNQNQKQIEF KNQYISSKGE
MGQDPESQNG KKIIKKREAN FSLEESCQWK INLFQNYINP QNQYLLCYNV IWLHHSETSS
IILADKSKKS QNQNLSIDFA NLYHKDNLEI KTGRSKTGDS FTDYSGETFG MWIIENKNFY
LGGHVEQFQP YRLKHLASGL YLSVQVKQQQ QNKPGYLTNE HTQTIDFDQR NSNNNKNLKT
NKNVNNNNNN INNNEQNNQT QYQLTLSNFP DETTLFQFEP LQKGNSHDET ANYIQGNSFV
YLKNIYSNGY IQVVNPYGQS VGAKYKKKQG IQLEPSITKE CSDDQLFNIY LSNDSIVWEI
KYVMQCFQKL VKLIKLLENS ERSEKITHRY LKKLQEKVSS ATLILKDLDL FLNNMRNNTS
LNVNYGIINH FRQKLLQEQY YIDILFRVLE ESLNIDEIIS WTKFSELKKF HKKDQDTRSV
QTDNRSYIDL RNLSVDSHHI NRSKNYTLSY ILDIKQRNQK RSGSYRNEQS QNNKYLIESI
KFSKSINLIY FFFKILIDPK SDNNMLLSAY QFLQAVCRFQ NDGVSQNQEI IYNLFCYYEN
EPEGEQITIP DFFDKQNMLV IDKNSQNLIR KQLFFYSDLA LARNFLWSKK LNPKFDMNTL
LKNVWPRQIN EILSESTKIK SQLAKLAMSL YIDHVHTKKH HQNLELGLAN FGNFLTQNVG
FSIYNKQVQE NEEIEEDETQ FSNTKDVDSF QNPLSRGVLM IHNVLQSIHY EDKQIFTSQV
NIKMQICDIL EQMLDFRQDF LLSNIIYWFT EQIAFTQLQN EDQLQDDNDQ QQNNIIEKIK
TNTRHILPNI SKTGINDIDE KLQQHDEDTG LFGIKKKKTF INFFDHLKDN KNTKNYQKQL
EKHKSFIQQQ SFKNTSSKNA SQIFQNQGKN SGKLDLIQDF IAEDQSDTNL KNQNQIQQKS
NLYQINEDQD EEENQSYNIF QQVIPEFYDL DSWLSASYKN VPAEKQPIGS VLPQLLTSFM
AVQDEELQKR VLKIDQNLLE MFADIIIREG RQAKFLSIFM SILKCKDKYV FENQLQVLNM
FLPLELKEKE KFLLFLEPNK KRDYFKDNSP QNNRKLKKQS SFNTAINAEN EDDLNLDQNH
INFDFEEAHN FQNNMTKSYN TSEQISLNFK DEPFQYHAKL LDLLIETTYI TEKNDYDEVY
EDNFDEKYDF NISIAKLRKT FNYSMLLNYL IEEKDDYIND NQFLDPNKTQ QNNLISGEPA
IDDVIKKQAR KKGMSILKPK ILDFLRILHV QSEKKQNIQK MDNLQEFRKK LCKFLDKESN
LIQSLNGKNI NNYQYIDYIF DSLLNFVLCY KKKYIQQQQH DDERIDEKSL HKLSDALSKQ
INLFEGKITQ RQIDRVEYFV NEYVQTDGYN GERFKVEFEG ITNLDFRGPL QKSTNKLPNK
IQNKFQGLFK NKQVNLNEKL FKQQVTIQNE LIPLRNLSSK EDEKNNKITS SLMNSQLEPM
SQQQMLQSPI ITDAQDIMPI LQSQRNSQLQ DSPKKSDKQG KKSVLKQKSF RFGNPFQLVG
NVTKFITSAS QKKEKQIDRQ DYKCDQIQEK WNTFVKEFTD ENNTQVQQEI QYERHAIANA
LLNINQLIDD ERKQDLEFTI DCKSLISKLI LLLQSAVSDK KYKDVVLNLL IILIEMVSKN
EDEQEKLQNQ FNSYGLTTVV LNVICDTETM DSYIFQQLIL LLNTLLQGGN INVQETIYKF
FITNKKSEKF FQKIYTFILD EIQKIEQISK QIKNRNRQNS MFSSQISSLF SSDPNLGQID
QDEDNEEKLE EEEKHHLELL QNILSFLQQS VEGHYLPLQK YFKEQTNSIN NYDIIFAIID
LIRVFYYDAA IQKYYSVLTQ SLETLIEFVQ GPCEQNQQAV SESKFLEIAH DLFTNKKKKK
KKTGLSSQFF GKQDTNLSSS SSKKKSNISQ NNRVRLEKQV EVETWQNNKP AESLTMELYN
KYTYAVINKE YEGFQKVFGD NLLGQLASFA QSLFQTGIGY AQKMKKLTID QLKQQKNLDE
EETQKQKSKR KEEKNKMYID SFNFFAKNTA QIEVNRNEKI ELVFFTKLPF SHFISQEQKR
NFQDNVNRST NKTKVEDLLA VSEDYIKQMK HQENLNHFFS HNPLLALLAN YDKLWKDLAF
LFTIIINIFI LTSFSTKFST DRLYGYHLFQ LEEYNTSRTK RYFQGLGLSM AISSGFVVAF
FLVKTLPLIV RKVWKKAQQG LLDKLIRWTI NLILIIYQVL QELEVMYYLA YGVFAIFGVT
LHPLFFTFHL TEILIRYPTL KNIINSVWYP RVQIGLAFLL FIILEYAFSI IGFLFFRDHF
QGNCDEMLIC FLFYFDWTFK ANGGTSGWIT DNSEESSQAD YVFGRFVWDT FSNYILVIIM
INIVSGIIID SFGDLRDKEY DKVVDITEKC FICGNDKSDF EKQIYSKGFQ KHIRIDHYMW
NYIFYIGYLE FKDPNDYMGI ESYVHQKLKN NDTSWFPFNK SRDVQSLDDE DIQENEILDQ
CQDDLISTPS KKSQIIYSLK IKSYKQFQQM NKSSHKNLNT LQSAQKMVQN TDNILKKLDN
DFKNLKNQKY FENPELANKN FQKRVSRQQS QISQHSIQSS LSKQKQTQKQ LESQQKLLQI
QSQQQQVDKQ LPPMYSISQK QAIDFKNQRS SVLEGATAHK IYTIQQFFHD FLKAENDNEN
FFQDSDFVMD FECLESKNAL ALTASNKDLF NHLTCQDIDT PIPETEIADI EQEEIDVEIF
QKKAVYPFRF YKNKFQKFSL ITDTVIPCLQ LPNQKLVPVF SRQQNPNHFW VSLIEKAYAK
LHQGYSRLEN LDLRTAINDL TGLEPDIINF HSKEQINTEN LIKILKLSKN NKSIVGFIRT
KPILSQNNQP SLNQQGKITV KANSTLINKM YIFSNIDKNN SLIIKNPWAQ TQPLNDSGSA
YITISFEDFF LLFDQIVILK DFSKEWRGIK YDPNIIGFIV QEIGERDLGA KILNFQQLKM
SYKSDQFSRK FVSGFAQLKK GRYTLVPFCN IQQPKGTYLI LEIYYNCKDN LIKFYEKQSK
EVILQDATND MTQTLRKLYD NIDLKNIQQY DLKPLISKEI KQFNLDAIAL LPTLYKEFLI
KNPNSWLLAM NETQKQLSKV EIPEKSQQQD PLLQNYEFNN IVSILLGEEE NEDDEINNTQ
IQKEQVTEDI VNYVEQESEG VYDFNYYGMG DKGLSAILEL LVQEHEIFEI HLSGNNLTDE
GILNLCYELE KSHHFELEEL DLSDNQITDL GAKTLMTFPS RMKNIVKLNV DQNENFPPIL
KEKINTFLLK RQNQIDNQ
//
