ID A0A0V0RM59_9BILA Unreviewed; 943 AA.
AC A0A0V0RM59;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 08-NOV-2023, entry version 22.
DE SubName: Full=Electroneutral sodium bicarbonate exchanger 1 {ECO:0000313|EMBL:KRX15519.1};
GN Name=SLC4A8 {ECO:0000313|EMBL:KRX15519.1};
GN ORFNames=T07_5720 {ECO:0000313|EMBL:KRX15519.1};
OS Trichinella nelsoni.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6336 {ECO:0000313|EMBL:KRX15519.1, ECO:0000313|Proteomes:UP000054630};
RN [1] {ECO:0000313|EMBL:KRX15519.1, ECO:0000313|Proteomes:UP000054630}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS37 {ECO:0000313|EMBL:KRX15519.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC {ECO:0000256|ARBA:ARBA00010993}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX15519.1}.
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DR EMBL; JYDL01000129; KRX15519.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0RM59; -.
DR Proteomes; UP000054630; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR Gene3D; 1.10.287.570; Helical hairpin bin; 1.
DR InterPro; IPR013769; Band3_cytoplasmic_dom.
DR InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR InterPro; IPR003020; HCO3_transpt_euk.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR PANTHER; PTHR11453:SF36; ANION EXCHANGE PROTEIN; 1.
DR Pfam; PF07565; Band_3_cyto; 1.
DR Pfam; PF00955; HCO3_cotransp; 2.
DR PRINTS; PR01231; HCO3TRNSPORT.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054630};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 423..445
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 478..503
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 510..528
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 597..618
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 630..651
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 682..701
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 722..746
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 803..821
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 841..858
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 864..882
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 107..346
FT /note="Band 3 cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF07565"
FT DOMAIN 392..453
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
FT DOMAIN 457..847
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
SQ SEQUENCE 943 AA; 106736 MW; C4CB966827D6A87E CRC64;
MNRIVRKISN TLGVTNQPRK DSFLDPRSDF LVDSLTMTQK IQIGLGENGT VQRLCSIMEE
DAVGPSENLP HPIFCEMLKL SDIKDENRFS AACWRELSRW IKYEEMVETG SSRWSKPHIT
LLTLQNLLQL KNSLRSCGEI LLDVNADSFA VLADKITESW GKSASLSRAE IKQCKEILMA
PKYHLIGSKF GSGKESSGSG NDSFYNLLEP LHEESIAAIA KGDKTYGTRS VHLNLLRKLQ
KDTEGACILI GSPDFLTYPL VQFVRLKTAT VMKNLFEIPI PTRFLYILLI PKDHMARDSD
TIGRCMGTLF VDEVFSHICY KAKDNLHLCY GIDEFLSQST IVPAGRLSTQ NRLEPHDNLL
PQKRCFGGQP TELIRSLSQT PETEVKLHRT GKLFGGLVED IKTKTPWYWS DFRDAFRGRI
TQTIAAAIFL FFANVSKIIT FGGVMDHVLH KQMVNTMFEV IMDVLCRKQG FDFLLIRLWV
GLWTGLMLII FVAIDASAFV AFITRFTEEA FATLISLIFL VKAVEELMEI SYDSPVVTSV
QNIFTSPCYC KFYSNDSVTL HEPYLLPPST LANSSREACL FDGGVIEGMQ CFYKPDVFMF
SIILFFATFF IAFGLKLFRH SSFFSSKVRH VVADFNVTIA ILLMTAAKWA VGTDVPCLEV
PDKLNPTRER DWILNPLDVK PWWMALACFL PACFFSILIL MDQNITSVII NRPENKLKKG
YGYHLDLAVI AVLMVVCSIF GIPFYVAATV ISLMHVESLR IMSETTAPGD APQFLGLKEQ
RFTALVAHLL IGLSVFLTPF MKLIPMPVLL GVFLYMGIVS LSGQQHQPDY TWLRQVQLKR
VNLFTIIQII CFLALAVVEE IKVISMAFPL MLLFMVAIRK VLLEKIFTSR ELTALDDLLP
PWKELIRPKP LPKDGHFDSN TKFTEQELQL LDESANDRLR EES
//
