ID A0A0V0RPK9_9BILA Unreviewed; 740 AA.
AC A0A0V0RPK9;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Type II inositol 1,4,5-trisphosphate 5-phosphatase {ECO:0000313|EMBL:KRX16248.1};
GN Name=INPP5B {ECO:0000313|EMBL:KRX16248.1};
GN ORFNames=T07_6706 {ECO:0000313|EMBL:KRX16248.1};
OS Trichinella nelsoni.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6336 {ECO:0000313|EMBL:KRX16248.1, ECO:0000313|Proteomes:UP000054630};
RN [1] {ECO:0000313|EMBL:KRX16248.1, ECO:0000313|Proteomes:UP000054630}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS37 {ECO:0000313|EMBL:KRX16248.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, phagosome membrane
CC {ECO:0000256|ARBA:ARBA00004580}. Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004146}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004608}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX16248.1}.
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DR EMBL; JYDL01000111; KRX16248.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0RPK9; -.
DR STRING; 6336.A0A0V0RPK9; -.
DR Proteomes; UP000054630; Unassembled WGS sequence.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016791; F:phosphatase activity; IEA:InterPro.
DR GO; GO:0046856; P:phosphatidylinositol dephosphorylation; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04380; RhoGAP_OCRL1; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR046985; IP5.
DR InterPro; IPR000300; IPPc.
DR InterPro; IPR048869; OCRL-1_2_ASH.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR047078; RhoGAP_OCRL1.
DR PANTHER; PTHR11200; INOSITOL 5-PHOSPHATASE; 1.
DR PANTHER; PTHR11200:SF299; PHOSPHOINOSITIDE 5-PHOSPHATASE; 1.
DR Pfam; PF03372; Exo_endo_phos; 1.
DR Pfam; PF21310; OCRL-like_ASH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00128; IPPc; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000054630}.
FT DOMAIN 546..737
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
SQ SEQUENCE 740 AA; 84754 MW; E5ED40505404444E CRC64;
MMRKAECDVT DLENHFGAQE KSYFDNSTSR LDSRMSFLRN KFTGSCSSFT THILQSKESE
YCTYKTLKLA TVWIYKFRVF VSTFNVNGQP PEANLLELFC QRVTDPPPDI YAVGFQELDL
SQQTFLFDIT SREEEWARVV LMNLKTVGDY VELKRVRLVG MFLVIYVTRE LHQRNVISEF
ATATVGTGVL NRMGNKGGVA IRFRLYDSWL CFVNCHFAAG ADELERRNQD FREISKTMFC
DLANLGIFDH DEIFWFGDMN YRLSEDGGRR TANATFVKEA CEIGLFESLL HLDQLSRMKS
IGLAFQEFTE GKITFLPTYK YDIGTDTWDS SEKGRTPAWC DRILWCGDHI EQIAYESVPS
VRMSDHKPVR AIFSLRAKVV DNKKLQTLFE AALRESDRLE NQWLPQVSLD KLEFEFKDVR
FLEPLCQPLT ITNIGRVPVY FEFRSESGQS VNCKPWLSIT PDKYRININE KCVVDLQVLI
DKETVWKIDS SGEKLDSILV LHLDNGKDFF ITVHAEYVPG CFGISLEKLY NTVQPGECSS
SASKLIDIDP VESADVKRSS SFPIPKEIWL LVDYIYKNGL DEENLFAQAG SHPEFISIRN
TLDAGNGKQL SGSVRSVAET LLRFLDSLPE PLVPTDVYEL CFRNVRDYGA CKRAIASFPT
LHNSVFIYLI CFLREVLHHS AKNKTSANGL AVIFAPILFR FPEPAGRIFT RRATLMQKMQ
LATQFLETLF RGKQDDLIEL
//
