ID A0A0V0S3N5_9BILA Unreviewed; 1452 AA.
AC A0A0V0S3N5;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902, ECO:0000256|PIRNR:PIRNR000619};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902, ECO:0000256|PIRNR:PIRNR000619};
GN Name=Egfr {ECO:0000313|EMBL:KRX21360.1};
GN ORFNames=T07_345 {ECO:0000313|EMBL:KRX21360.1};
OS Trichinella nelsoni.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6336 {ECO:0000313|EMBL:KRX21360.1, ECO:0000313|Proteomes:UP000054630};
RN [1] {ECO:0000313|EMBL:KRX21360.1, ECO:0000313|Proteomes:UP000054630}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS37 {ECO:0000313|EMBL:KRX21360.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC kinase family. EGF receptor subfamily. {ECO:0000256|PIRNR:PIRNR000619}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX21360.1}.
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DR EMBL; JYDL01000040; KRX21360.1; -; Genomic_DNA.
DR Proteomes; UP000054630; Unassembled WGS sequence.
DR GO; GO:0098590; C:plasma membrane region; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0038127; P:ERBB signaling pathway; IEA:UniProt.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0042127; P:regulation of cell population proliferation; IEA:UniProt.
DR GO; GO:0000003; P:reproduction; IEA:UniProt.
DR CDD; cd00064; FU; 4.
DR Gene3D; 3.80.20.20; Receptor L-domain; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR006211; Furin-like_Cys-rich_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR032778; GF_recep_IV.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR000494; Rcpt_L-dom.
DR InterPro; IPR036941; Rcpt_L-dom_sf.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR InterPro; IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
DR PANTHER; PTHR24416:SF566; EPIDERMAL GROWTH FACTOR RECEPTOR; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF00757; Furin-like; 1.
DR Pfam; PF14843; GF_recep_IV; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF01030; Recep_L_domain; 2.
DR PIRSF; PIRSF000619; TyrPK_EGF-R; 3.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00261; FU; 7.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR000619};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|PIRNR:PIRNR000619};
KW Membrane {ECO:0000256|PIRNR:PIRNR000619, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR000619};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|PIRNR:PIRNR000619, ECO:0000313|EMBL:KRX21360.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054630};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR000619};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|PIRNR:PIRNR000619}.
FT TRANSMEM 927..949
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 988..1253
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT ACT_SITE 1121
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000619-1"
FT BINDING 994..1002
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000619-2"
FT BINDING 1021
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000619-2,
FT ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1452 AA; 163492 MW; 0A0F71378C34610D CRC64;
MTCCTQAAFN SKALCHKLQL CCCCRYKRFN SSHDVEEEQE EVSSQISPMV HFRISHLNVL
LVLSLPAVLC YRSTSTKKSE SKNWFHQKVW HSTLQLNADC CHMHAMKLIS KDKRVDFHLF
NELSDPILLR YTEFLFSIVV CSGTENGLNK LEVHEKKVER LRMMYANCTV VHGNLEITYL
TPDDLKDAGI SDLHFLNDIV EVTGYVLIAH NSIRNFSLPS LQIIWGDKKF RPTSDQMVSQ
FGLLVLNNAF STFDLSNLRA IHDGSVGIQM NHRMCHWKTI DFRQLLGDNY EKRLIIRDSY
GDCYADAVCD SSCVHCWGSE KRQCQKIYRN NCAPQCSSGM CYDVESPQFC CHPECAAGCF
GPSDSECYGC STMRDNGKCV DKCPTPELYD PITTQYVKNP DGKYAFNRDC VTTCPAHMVV
YKDGCVSRCP ENFTADEGDN VCRPCQGACP KTCIIEQHVN SLNIKDFIGC TKVDGVIEIR
KDTFIGGALL QPNGTFIPYD PMTPAQLEAL SSVRQVTHYV LIQTEKLKSL NFLRNLQKIE
GRKLFDSKYA LYITHSFSLQ QLGTISLTSI LNGEIYIASN FDLCYIHNIP WNKLIAPTHS
VAKVRKNREE DVCEAEGRTC DVSCDLSQGC WGPGSEMCFE CLHWRLGNVC VDDCSSDGEY
QAAPKQCALC HPECISCTGP GSRNCTKCRH VSLDGECIRS CPQETHFENP ATHVCEPCHA
NCYSYGCTGS GNFVGIAGCN RCKYGVFDED TQSITRCLRE LSAERLCSEF PDLENYYWTV
PLSTKIQTEV AHAVCMKCHP ACKSCYGYGV DFVHYGCDCL NYTYRETPTS SVCVLQCPKN
TFIRPALDSG RADECIPCDS QCDGCIGPTS TDCVECVTYK DYLSDTDRFN CTNVCPADRP
YISADRLCTD INMDEVIYEK NKRMQTIVIS AVVAALFLGF VVFLILILFM KRKASLLAHL
EEPDPKLEIN SEACPNLTRL LLIRESELKR GGILGYGAFG AVYKGVWIPQ KEKVKVPVAI
KVLHEANAAA QQETLEEARI MASVSHTYLV RLIGVCVGQQ MMLVTPLMPL GNLLDYVQEN
KSKIGSAALI RWSSQIAGVR ITDFSISGMC YLEEHRLVHR DLAARNVLVK TPYHVRITDF
GLAKLLEYGQ EEIKIFEGKM PIKWLALECI QYRRYTHKSD VWAFGVTLWE LFTFGEKPYK
DVPLHDIPRL LENGERLPQP KIATLDMYML LIRCWMVDAD ARPSFKELRE SFLKMAKDPG
RFLVVEGDAL LRLPTYTPQD QQQMIRQLID DPDVIDPEDY FSAPTASPLV SPVTPTKPLI
DDVEMRLACG PPHRHAGSVS QRYASDPVKS KLLDNSSLST DQDNYLIPDS QQPQRQSFIH
EDDGVFVNYS PMPAYNGYKV GNHVYYNDFP PEKSGICLEN FEYMQGGNGG AIYTNTCPVD
CNADSVQTET VV
//
