ID A0A0V0SFC0_9BILA Unreviewed; 1886 AA.
AC A0A0V0SFC0;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=CLIP-associating protein 1-B {ECO:0000313|EMBL:KRX25454.1};
GN Name=XRCC6 {ECO:0000313|EMBL:KRX25454.1};
GN ORFNames=T07_2630 {ECO:0000313|EMBL:KRX25454.1};
OS Trichinella nelsoni.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6336 {ECO:0000313|EMBL:KRX25454.1, ECO:0000313|Proteomes:UP000054630};
RN [1] {ECO:0000313|EMBL:KRX25454.1, ECO:0000313|Proteomes:UP000054630}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS37 {ECO:0000313|EMBL:KRX25454.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ku70 family.
CC {ECO:0000256|ARBA:ARBA00005240}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX25454.1}.
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DR EMBL; JYDL01000012; KRX25454.1; -; Genomic_DNA.
DR Proteomes; UP000054630; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0043564; C:Ku70:Ku80 complex; IEA:InterPro.
DR GO; GO:0005819; C:spindle; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0042162; F:telomeric DNA binding; IEA:InterPro.
DR GO; GO:0015631; F:tubulin binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IEA:UniProt.
DR GO; GO:0000278; P:mitotic cell cycle; IEA:UniProt.
DR GO; GO:0031110; P:regulation of microtubule polymerization or depolymerization; IEA:UniProt.
DR GO; GO:1902903; P:regulation of supramolecular fiber organization; IEA:UniProt.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR CDD; cd00788; KU70; 1.
DR Gene3D; 1.10.1600.10; -; 1.
DR Gene3D; 2.40.290.10; -; 1.
DR Gene3D; 4.10.970.10; Ku70, bridge and pillars; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 4.
DR Gene3D; 1.10.720.30; SAP domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024395; CLASP_N_dom.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR006165; Ku70.
DR InterPro; IPR006164; Ku70/Ku80_beta-barrel_dom.
DR InterPro; IPR027388; Ku70_bridge/pillars_dom_sf.
DR InterPro; IPR047087; KU70_core_dom.
DR InterPro; IPR005160; Ku_C.
DR InterPro; IPR005161; Ku_N.
DR InterPro; IPR036361; SAP_dom_sf.
DR InterPro; IPR016194; SPOC-like_C_dom_sf.
DR InterPro; IPR034085; TOG.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR InterPro; IPR048491; XMAP215_CLASP_TOG.
DR NCBIfam; TIGR00578; ku70; 1.
DR PANTHER; PTHR21567; CLASP; 1.
DR PANTHER; PTHR21567:SF9; CLIP-ASSOCIATING PROTEIN; 1.
DR Pfam; PF12348; CLASP_N; 1.
DR Pfam; PF02735; Ku; 1.
DR Pfam; PF03730; Ku_C; 1.
DR Pfam; PF03731; Ku_N; 1.
DR Pfam; PF21041; XMAP215_CLASP_TOG; 1.
DR SMART; SM00559; Ku78; 1.
DR SMART; SM01349; TOG; 4.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF100939; SPOC domain-like; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000054630};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 162..199
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT DOMAIN 1327..1535
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 622..732
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 651..732
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1886 AA; 210495 MW; A3DB5172D52CDA8D CRC64;
MGNFSELLNK NSTDPKTRVE LGQQLLDLIQ REGVPNDANN LTLFMDVMVQ WLNGTNFKVA
LLALEILSLS LEVSGATVSH IVLENASTIM ERLGDNREQV RQDAVGLLLK LMNTPGCTPQ
GVLDRIVEGF SHKQWLVRIG VMIVLQQILR SYGPSCLQLG KLVPSICRLL ADPMNQVRDV
ATETLVEMYV FLGDKLAMDI QRKQLVPNAR AAALFSRFED VKRNGLVGSS CSSNGTVGSA
LESVADFTDA TPTAHRQISS VSTLKKPLLT AVKQSEVSNF TGKRATSAPP VKRLQTTSRY
AGNAGAVDEE SFYAAFEDVP KVEIYSAKEL SIQLQQIRTI VMNTNGDWEK RVDSLKRLRS
LLISGASQYD EFFVELRSLE VPMQIAGKDL RSQVVREVCI TVAYLAERLG PKFDHFAEII
LPLLISLIQN SAKVVSTSGL ISCRFIIKNT HAPRIVPVIT GSLESKSKEI RRCCCDFIAM
MCQQWSSHEL EKNVGALQGA IRKGLSDADP EARAFSRKAY WSFSDHFRDQ AEMLFQSLDP
GKQRQLLGEV SQSSSSHSLY NDLRTSQESV KCSTASQYGA SRAGGTIPCL RSASEIDTGA
VRRAVAMKQA NAGKAFLGVA SSSNMNSLPR PMKMLLSTSG NHPKFGRFGA PNPSTATTAT
STRLESTPRS PTSTSNKSVS QPGSRSSSPT ARSSLTNSAR RARPIANITG FRSQTSSRDS
SPSRTPRRLS TPDRSYYSFG RFFCTPARDA DCANVVGVNR GRKLDDVSSE SSPCFFGERS
FRGSESSENS SSMMDVLRSC SSTVWIERKE GLLCLQSFFR SGGRLTAGEL KKACDLFARL
FVDPHHKMFT VFLDTVIEFL QAHGSDIQDW LFVLLCRLLS KQSNELLPSV QSKLLKTMDV
VRAVFPVEAQ FQALTRYLVD PTQTPNVKMK LNVLNYLNAL IYSMQSCHLT DTADMRMAIS
RIVQWTGEPK STEVRRTAQA TLLALFSLNT AMFSQILSSF SKAYQDTVSR ILHTHVRHFP
DLSTLCIHDS AEQSSKVIER NSDVQDSLRR TSEEIMRYPF SSDCKTTGSN GSTVMDSVDN
YFKNGSAGQG GRLELLSNGV NTDEERQEEI IGQILTELSN HNARNVERKK ALSTLKHVSR
DGSFTLWEEN FKTILLILLE TLGDDDPDIR AAALPVLKEI CTRQPQRFQD YAELTILKLL
DAHKDPERKV TRAAEDCATV LALHLAPLVC LRVLTPVILN DQGPALLAAI KMTTKVIEQM
DTDELLRILK ELVPGIIMGF ENPTDSSVRK ASVLCLVAVH KKVGFEVLEP FLEPLNSSKP
TWAGRKCIIF LVDCDSAMFT EAACTAFQES ITAIRDIYCH NSVTGERDYL ATVLYNTKKG
ENSHRFNGIS VLHNLSLPSV EKVKQLERLC NGMRECGPPF NYFDENYGTG QSNIDEVFWL
SAMMYNECKV QNQRRTIFLF TNNDSPHHGD VELRKRGRKK IKDLKEKNVT VEVVAVGTTN
FVLDNFYKVA LADEHACHDD NLTLANRADD LFSRIVKKTR TKRGFATLNF SLGPGIDISV
TLYNNISTAN LPPSVMLDGR TNGEVKLISN LFDPETGEKL HRFNLVKYQE YGRRRIAMTE
KELEEMSSFT SPGLVLLGFQ PLNRLKVYHH LRPAFFISPN ENIIKGSTVL LSALMRKCSD
KEMTMICRLT ARKNTSPRLV ALVAEIESEE AAQSTKCRRF HGIYLPYEDD LRDLQAVIAS
VPKIQVDNQL VDLWKKVIKR MQIQYTVGTI QNPVLQKHYR TLEAVVLDRE KIGHFVDQTM
NLKWIDNEAG MLLEQIKEHL NFDDQKKSSS GYTDVEFDLE AEARNGLLGK RTVVQLRNAL
RSKGIVIASN TRKPDIIKRI LDLYAL
//
