ID A0A0V0TPH2_9BILA Unreviewed; 856 AA.
AC A0A0V0TPH2;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=ire-1 {ECO:0000313|EMBL:KRX40403.1};
GN ORFNames=T05_1018 {ECO:0000313|EMBL:KRX40403.1};
OS Trichinella murrelli.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=144512 {ECO:0000313|EMBL:KRX40403.1, ECO:0000313|Proteomes:UP000055048};
RN [1] {ECO:0000313|EMBL:KRX40403.1, ECO:0000313|Proteomes:UP000055048}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS417 {ECO:0000313|EMBL:KRX40403.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX40403.1}.
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DR EMBL; JYDJ01000201; KRX40403.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0TPH2; -.
DR Proteomes; UP000055048; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0004521; F:RNA endonuclease activity; IEA:InterPro.
DR GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd09769; Luminal_IRE1; 1.
DR CDD; cd10422; RNase_Ire1; 1.
DR Gene3D; 1.20.1440.180; KEN domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR045133; IRE1/2-like.
DR InterPro; IPR010513; KEN_dom.
DR InterPro; IPR038357; KEN_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR018391; PQQ_beta_propeller_repeat.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR13954; IRE1-RELATED; 1.
DR PANTHER; PTHR13954:SF6; NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF06479; Ribonuc_2-5A; 1.
DR SMART; SM00564; PQQ; 4.
DR SMART; SM00580; PUG; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR PROSITE; PS51392; KEN; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KRX40403.1};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000055048};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..856
FT /note="non-specific serine/threonine protein kinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5006869318"
FT DOMAIN 474..726
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 729..856
FT /note="KEN"
FT /evidence="ECO:0000259|PROSITE:PS51392"
SQ SEQUENCE 856 AA; 97422 MW; 9F7E0A813EF0779B CRC64;
MCDWKCKIIF LLICFACSAE SDITNAKEVN VTPSSDSFRD CIFISTISGA LYVVDSITGN
IKAVLQECMA PVSTAPLNIR SVFTFLPDPR DGSLYVINKG ELKKLPFTIP TLVQLSPCKS
SDGLLFAGTK QDSWLAIHKR PYNNVEISRV DDIAQRTCPA AYKSAIFIGR SEYRVHMVDS
MNANKRWNVT FVEYATGIIP IQSDYSFEYY SSCSDGLLVT VDANSGRIIW SKNFNSTIVD
VYQLQLDGLK RLQLNVFGKD TLEHFVDQQL SQMKDQISPT EDDTFVPSGR TLYPSVYIGE
HSDGLYALPS LVDEKTVVLS FNMDKVPRIA GPHPVVDPES IVDTGTGRIH VDIDRLRWKV
KYTLNGEQPV IFLGHHEVPS TMETLLVFNN SPKPTLNLLT AASDEAYTKS RQRWVREEIA
DTVFKELSIW NYLPTVATIL VTTLLVRYVL SLSIGKKSKF CKNKTENRVG RILLYKNEVL
GRGSDGTVVY KGDFDGHPIA VKQMIRHFAS VAHHEVQVLR RSDRHPNVIR YYCTESDEQF
LYIALELCSF TLEKYVEQPE MKELCHLQPQ ILLKQISNGL QYLHQLGIVH RDLKPQNVLI
ASTADNTRAL LSDFGLCRTL HSKSWTHGSG SIGTVGWIAP EVIRLNLITF ASDVFSLGCV
YHYVLTEGEH PFGDIFYRQA NIAVGRYECC PSKRLKAEEA NLVMQMIHSV PAARPKMVHV
LKHPFFWPKS KQLSFFLDVS DRVEKETAQC ELVQHLEHRS SVIVNRDWRQ CICPLLQADL
RRFRTYRGGS VCDLLRAMRN KRHHYYELPE DVREALGTIP DGFIDYFTKR FPLLLIHVYE
AMRAAGEEPL FKVYYY
//
