ID A0A0V0TVC0_9BILA Unreviewed; 601 AA.
AC A0A0V0TVC0;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Glucose-6-phosphate isomerase {ECO:0000256|ARBA:ARBA00018388, ECO:0000256|RuleBase:RU000612};
DE EC=5.3.1.9 {ECO:0000256|ARBA:ARBA00011952, ECO:0000256|RuleBase:RU000612};
GN Name=GPI {ECO:0000313|EMBL:KRX42996.1};
GN ORFNames=T05_6671 {ECO:0000313|EMBL:KRX42996.1};
OS Trichinella murrelli.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=144512 {ECO:0000313|EMBL:KRX42996.1, ECO:0000313|Proteomes:UP000055048};
RN [1] {ECO:0000313|EMBL:KRX42996.1, ECO:0000313|Proteomes:UP000055048}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS417 {ECO:0000313|EMBL:KRX42996.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate;
CC Xref=Rhea:RHEA:11816, ChEBI:CHEBI:57634, ChEBI:CHEBI:58225;
CC EC=5.3.1.9; Evidence={ECO:0000256|ARBA:ARBA00029321,
CC ECO:0000256|RuleBase:RU000612};
CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC phosphate and glycerone phosphate from D-glucose: step 2/4.
CC {ECO:0000256|ARBA:ARBA00004926, ECO:0000256|RuleBase:RU000612}.
CC -!- SIMILARITY: Belongs to the GPI family. {ECO:0000256|ARBA:ARBA00006604,
CC ECO:0000256|RuleBase:RU000612}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX42996.1}.
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DR EMBL; JYDJ01000130; KRX42996.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0TVC0; -.
DR STRING; 144512.A0A0V0TVC0; -.
DR UniPathway; UPA00109; UER00181.
DR Proteomes; UP000055048; Unassembled WGS sequence.
DR GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro.
DR GO; GO:0004347; F:glucose-6-phosphate isomerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
DR GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR CDD; cd05015; SIS_PGI_1; 1.
DR CDD; cd05016; SIS_PGI_2; 1.
DR Gene3D; 1.10.1390.10; -; 1.
DR HAMAP; MF_00473; G6P_isomerase; 1.
DR InterPro; IPR001672; G6P_Isomerase.
DR InterPro; IPR023096; G6P_Isomerase_C.
DR InterPro; IPR018189; Phosphoglucose_isomerase_CS.
DR InterPro; IPR046348; SIS_dom_sf.
DR InterPro; IPR035476; SIS_PGI_1.
DR InterPro; IPR035482; SIS_PGI_2.
DR PANTHER; PTHR11469; GLUCOSE-6-PHOSPHATE ISOMERASE; 1.
DR PANTHER; PTHR11469:SF1; GLUCOSE-6-PHOSPHATE ISOMERASE; 1.
DR Pfam; PF00342; PGI; 1.
DR PRINTS; PR00662; G6PISOMERASE.
DR SUPFAM; SSF53697; SIS domain; 1.
DR PROSITE; PS00765; P_GLUCOSE_ISOMERASE_1; 1.
DR PROSITE; PS00174; P_GLUCOSE_ISOMERASE_2; 1.
DR PROSITE; PS51463; P_GLUCOSE_ISOMERASE_3; 1.
PE 3: Inferred from homology;
KW Gluconeogenesis {ECO:0000256|ARBA:ARBA00022432,
KW ECO:0000256|RuleBase:RU000612};
KW Glycolysis {ECO:0000256|ARBA:ARBA00023152, ECO:0000256|RuleBase:RU000612};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|RuleBase:RU000612};
KW Reference proteome {ECO:0000313|Proteomes:UP000055048};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..601
FT /note="Glucose-6-phosphate isomerase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5006869633"
SQ SEQUENCE 601 AA; 67332 MW; 4F1A88501DF7B04A CRC64;
MALFLFCVTF SVVVDDNSAN DLRHFWLAAN ISLSDLLFGV NCCSTMALQT SLSSDRIYTE
LRTYVHNKGR HLNMKEMFES DPQRFEKFHL KLKCGKEEVL FDYSKNLINE ELLEKLMSLA
RARKVEQVRQ AMFSGQKINI TEDRAVLHTA LRNRSNTPIL VDGKNVMGEV NRVLMQMKTF
TDNVLTGKWL GCTGKQITDV VNIGIGGSDL GPLMVTEALK AYQQGPNVHF VSNIDGTHLA
ETLKRLNPET TLFIIASKTF TTQETITNAE SAKEWFLSNV QNPEAVAKHF VALSTNANKV
KEFGIDPGNM FEFWDWVGGR YSLWSAIGLS IALFLGMDGF EQLLAGAHFM DEHFLQAPLE
KNMPVIMAML GILYINFHGA ETHALLPYDQ YLHRFAAYFQ QGDMESNGKS VSKHGRRVDY
ATGPVVWGEP GTNGQHAFYQ LIHQGTRLIP CDFILPIQSL NPIRNGLHHE ILTANFLAQT
EALMRGKTEN EVKMELKSAG MSDAAIGRLC PHKVFQGNRP SNSIVLTKLT PFTLGLLIAA
YEHKIFVQGV IWDINSFDQW GVELGKQLAK VIQPQLKGTD TVTSHDSSTN GLINFIKTHK
A
//
