ID A0A0V0U025_9BILA Unreviewed; 1157 AA.
AC A0A0V0U025;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 22-FEB-2023, entry version 30.
DE SubName: Full=WW domain-containing protein {ECO:0000313|EMBL:KRX44610.1};
GN Name=tag-325 {ECO:0000313|EMBL:KRX44610.1};
GN ORFNames=T05_1901 {ECO:0000313|EMBL:KRX44610.1};
OS Trichinella murrelli.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=144512 {ECO:0000313|EMBL:KRX44610.1, ECO:0000313|Proteomes:UP000055048};
RN [1] {ECO:0000313|EMBL:KRX44610.1, ECO:0000313|Proteomes:UP000055048}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS417 {ECO:0000313|EMBL:KRX44610.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX44610.1}.
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DR EMBL; JYDJ01000092; KRX44610.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0U025; -.
DR STRING; 144512.A0A0V0U025; -.
DR Proteomes; UP000055048; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd13233; PH_ARHGAP9-like; 1.
DR CDD; cd00201; WW; 1.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR23176:SF129; RHO GTPASE ACTIVATING PROTEIN AT 16F, ISOFORM E-RELATED; 1.
DR PANTHER; PTHR23176; RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00456; WW; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF51045; WW domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000055048};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 71..95
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 107..128
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 526..559
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 727..827
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 929..1153
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 433..482
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 870..891
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1090..1120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 876..891
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1157 AA; 130338 MW; D16673A9C758BE37 CRC64;
MFFGIRVLSL HVAGKELKKT FSPISQALFK FYSSLNSKQK YILFQATRRC SVYTQDGIHW
LPLYRFKWMP IIASISRIKI AQTVLSVIFV PVAYLAYQDK QISLNQLYVL VFICVFALFM
LCVMSGIFRR LIGVVSLDES RNVIRIGHLT FWGARRNVEI PLEDLTPLSE VNFRPGDIYA
AIRRYSDSKF HLYLPLKGYE VVNKQKLINL SRSVALLSGH CVARLTLSSE MIRGTEIKLL
LLPDAICHRS CMLDFRMCLS LVEVLYNYDS TTSRGHRVHV LAGEKFYLVS DADEHWWFVC
KDWSNIDGFY LPKSYLRVLS VQSGILSPDQ TSAVISDDDD DDVCSGTSKD ERIRTSVANG
HRPFVVAEVE EAEENLPADR WPAMHANGKG GKLSSARLVS ASIPVGLEMY CLERADQRSA
LLNGDHGLVG VETSSSSGRC STFGTAGAQS RSLDNDLPMS STCSSSTDSR NSSRNSSSSS
VVTAMDSVSV SDALANARSR SPIYANIEEC TDMSIPAITP DMQPIRTLSN GWQEYISESG
RPFFYHPLIE IASWKPPRSS TSTTNQQCSV ASSTRTMLDS SSSSVLDNLS EVVDRRRAVV
DDVGLSSLLN KPKNDHCGWS KSKLRTDVDM EPQQHQLQQQ QQLQRSGFSI GEEVDDGRGE
HCVRVSIRDF SDLNRLLSTS QQHPATRPTS TSLYGQCMSA SDGALKFSAF HSSTGTVIKC
GNLNRCKVME AGKRIRKHWS TCFVYLTNAH MIFYKDKKSS EKQGNQYCAP LGVCDLHGAK
IKWLVDDKNK RKRLFQLELV DGTAYLFHTE VDNEIIDWYD ALQKIVNELP NPGFQRTPVI
ERSSYKTSSR RVSTTTGQKI AKDAKNLHDY KEKQSTSRNI NGPTSDSVEA SVPSKQSILE
KLVRFFRNRP SVEFLKERGI YKPEPVFGSS LTEICRREKN TVPKFVTVCM SLIEERGLET
DGLYRMSGNL SQIQKIRCSV DQEKYNVLMN ENDIHVLTGT LKLFFRELQE PLFPPFLMKE
FMNAIKLQNA KLRYCAFRDL VARLPPPHHD TLNALLIHLL KVAEKSSTNR MQIHNLAIVF
GPTLFSSCPK PEKAESGGQR RKKMMMKKSA SKYSEPSTSG HVDVIQSNSH LAFSMIMHGQ
IVEYMLKEHS KLFKVKV
//
