ID A0A0V0V8M6_9BILA Unreviewed; 1510 AA.
AC A0A0V0V8M6;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Tyrosine-protein kinase-like otk {ECO:0000256|ARBA:ARBA00034533};
DE AltName: Full=Tyrosine-protein kinase-like 7 homolog {ECO:0000256|ARBA:ARBA00034559};
DE Flags: Fragment;
GN ORFNames=T09_15830 {ECO:0000313|EMBL:KRX59852.1};
OS Trichinella sp. T9.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=181606 {ECO:0000313|EMBL:KRX59852.1, ECO:0000313|Proteomes:UP000054681};
RN [1] {ECO:0000313|EMBL:KRX59852.1, ECO:0000313|Proteomes:UP000054681}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS409 {ECO:0000313|EMBL:KRX59852.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Acts as a calcium-dependent, homophilic cell adhesion
CC molecule that regulates neural recognition during the development of
CC the nervous system. Component of the repulsive Plexin signaling
CC response to regulate motor axon guidance at the embryonic stage. Also
CC component of a receptor complex that is required in the adult visual
CC system to innervate the lamina layer; specific targeting of R1-R6
CC axons. {ECO:0000256|ARBA:ARBA00034468}.
CC -!- SUBUNIT: Interacts with plexA; component of a receptor complex that
CC mediates the repulsive signaling in response to Semaphorin ligands.
CC {ECO:0000256|ARBA:ARBA00034516}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX59852.1}.
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DR EMBL; JYDN01000067; KRX59852.1; -; Genomic_DNA.
DR Proteomes; UP000054681; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00096; Ig; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 7.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000717; PCI_dom.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR PANTHER; PTHR24416:SF573; INACTIVE TYROSINE-PROTEIN KINASE 7; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF13927; Ig_3; 4.
DR Pfam; PF01399; PCI; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00409; IG; 5.
DR SMART; SM00408; IGc2; 6.
DR SMART; SM00088; PINT; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 7.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50835; IG_LIKE; 6.
DR PROSITE; PS50250; PCI; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 4: Predicted;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Kinase {ECO:0000313|EMBL:KRX59852.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000054681};
KW Transferase {ECO:0000313|EMBL:KRX59852.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1078..1104
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 184..349
FT /note="PCI"
FT /evidence="ECO:0000259|PROSITE:PS50250"
FT DOMAIN 441..534
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 542..607
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 611..700
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 776..873
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 882..975
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 980..1041
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1196..1501
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1222..1246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KRX59852.1"
SQ SEQUENCE 1510 AA; 170764 MW; 50DF9128046F4881 CRC64;
LKFENNESIL KLKFTMENNM KVRVFDFRPP ADHVKILLNY LKMISILGEY VEKKPNEADL
ESVLMSLSSL IPSVLEAEES SKIVEELCKK FTEPVFRDRE QIIFRAITNL FYAMEDVHPV
SYRHQYKLFM GMLNLSCHCK PSNIPLRIIS LEQASQWLNQ WKCNLQERRD CFRLLHRTLL
NSEEIGAPAK VMYELLSSYT TEADAYIAGD DARECVRSAI NDPRTFIFSH LFSLLPVQQL
ADEPIHRLLT IFDSGSLDDY IMFYEQNKQF VDETMGLSNE QYLYKMRVLT FMSIAEKRKE
ISLSELMNLL KMEDERSLEE FVIKAIQSEM VKAQIDDAAK IVLLHGAQSR SFGKRQWEEV
LNGLKKSLTQ PTLDYSGKAV FAQQWPSDAL DAEAIQSHSR LSGWFVVEFS VFAFRVVMVA
NFPRTLVTVC IVLGVSSARG PCVEDESFYF NVQPKGITVR EGSRAFLECN VSSDCNMQFH
WVLNDEIVVN NTRRYQNGSN LVITRVNRSL DYGEFFCIAT IATTGLAKQS QPASLAILWL
KENVSVTALS SAEMRGELQL RCDAEGYDEP LYRWYHNGHR LRRSERVTWR GRRLTVHAVT
VHDNGVYRAV PKIVTVPQNI IAPVGWSALF DCAYDGAEKL YWKAGNYPDL LIGTDSSQRI
YQLANNSLLI TSVLASDEGN YECVGEANIK SSLPKKQSYS AHLAMPTLGL FRGTNFEPVR
DIYVVGQGKR FEIACVPPSG RPMPKIHWTR NGQRVSDVGR VRSSDDYSLV IDSAQPPVIE
RHPSSLEVEE GSEARLDCSY RGNEYPVTVV DWEKDQSVIS PVRPLLATVR RKQFPDNGTL
LIYSVSMADS GEYTCVVKTL EQHPVYSQPA ILRVLERLKF SPRPVDRKLE LNSDVQIPCR
AVGHAPTKVK WLRLSSLSTD GTETQYQQPL TNLSPHIRDK DGMLYFHNAQ FDDAGYYMCV
AVSSQGVINV TIKIEVVVAP IFDLVPNNVT VEEEQNVWLH CAVRGTPSPT VRTFAHRKYS
NNTLLLIKPT VEQAGKYNCM AVKLSNISHC GRHIGLQRSF SDIDSAELMK NERNGMTLAT
TGIACGAAAG YILLVVFLVS YCGYRRRRGR LIKAHQGQST TPLQVQIVEQ HLAGKGAVCS
SLTTSAHSGG ELLLKGGNYS SNGSTTSQPV RATLSSSKRA RFVSTFKHLQ FPREQLRYRS
TLGSGVYGEV YLMFKTENQL QEQQQQQQQQ EQQPSDGVFD SATTTTATAT TTTTTTVVVK
SLLTKEEWVQ TEFMQELELY ARCDHPNVAK LLGVCASAEP ILVIFDYLDY GNLKHYLQAS
RHYKSPVSLL QASYPPPLTS SQIFSIVYQV AEAMQHISDR RFVHKDLAAR NVLLSSKYFV
KVTHLSLSND QFLAEYYTYR NLVLPLRWMP DEALFDDDWS VKSDVWSFGV FVWELLTMGE
LPYQSCSNDD VIEYLKCRQL KLALPGGPVP SILRKLIADC MAVNPKDRPL FSEIRERLAM
LSLSSSSSSD
//
