ID A0A0V0W1Z4_9BILA Unreviewed; 1711 AA.
AC A0A0V0W1Z4;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Protein HIRA {ECO:0000313|EMBL:KRX69688.1};
GN Name=UBA2 {ECO:0000313|EMBL:KRX69688.1};
GN ORFNames=T06_11339 {ECO:0000313|EMBL:KRX69688.1};
OS Trichinella sp. T6.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=92179 {ECO:0000313|EMBL:KRX69688.1, ECO:0000313|Proteomes:UP000054673};
RN [1] {ECO:0000313|EMBL:KRX69688.1, ECO:0000313|Proteomes:UP000054673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS34 {ECO:0000313|EMBL:KRX69688.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Protein modification. {ECO:0000256|ARBA:ARBA00043952}.
CC -!- SIMILARITY: Belongs to the WD repeat HIR1 family.
CC {ECO:0000256|ARBA:ARBA00007306}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX69688.1}.
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DR EMBL; JYDK01000334; KRX69688.1; -; Genomic_DNA.
DR Proteomes; UP000054673; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0008641; F:ubiquitin-like modifier activating enzyme activity; IEA:InterPro.
DR GO; GO:0006338; P:chromatin remodeling; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 1.10.10.520; Ubiquitin activating enzymes (Uba3). Chain: B, domain 2; 1.
DR Gene3D; 3.10.290.20; Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR031120; HIR1-like.
DR InterPro; IPR011494; HIRA-like_C.
DR InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR InterPro; IPR023318; Ub_act_enz_dom_a_sf.
DR InterPro; IPR035985; Ubiquitin-activating_enz.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13831; MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS; 1.
DR PANTHER; PTHR13831:SF0; PROTEIN HIRA; 1.
DR Pfam; PF07569; Hira; 1.
DR Pfam; PF00899; ThiF; 1.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF69572; Activating enzymes of the ubiquitin-like proteins; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Reference proteome {ECO:0000313|Proteomes:UP000054673};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 13..68
FT /note="THIF-type NAD/FAD binding fold"
FT /evidence="ECO:0000259|Pfam:PF00899"
FT REPEAT 522..553
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 578..610
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 621..653
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 1176..1371
FT /note="Protein HIRA-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07569"
SQ SEQUENCE 1711 AA; 191037 MW; 88CDDBFC9360827C CRC64;
MGENQEFLDM YHSFTNKKLL VVGAGGIGCE LLKTLVLSGF ADIEVIDMDT IEVTNLNRQF
LFRKEHVEAR SYVNRMCLIC HLPLIDGGSL GRKGQVDVII RNITECFDCH KHSPSHDYPS
CTIRNTPTEP AHCVIWAQHL FNQLFGEVNS DQDVSPESLV TGEEFEATPQ VQPLTSIISL
QDLAKNHNYD PELFVNDIEY LRTMEKLWEG RQPPTPLNLR WFRIGLDESL QGTEQKDWES
RDQNVWTLKE CFKVAVSCLA VLKERAKTAP LIWQKDDPVC VDFVTAFTNF RCHVFNIEKI
PRFEAETIAG RVVPAIVSTN AVVAGLMVLK LYAVLERRKD FYGSVAISSQ EGMPRVLSIA
PSTEVTGCEY CVAVKEVHMQ RFSIAKELSV MKPEIMLEVA SPRLLFAHDY KLSAEEGKKT
LSEISVKHGS LLRCEDGATF TNIPRRFTTA NKSNIELIGN EVHKAELGLP IYSVDIEPAG
NRFATGGQSV TGIGLIVLWS LKPVIDVENE TNDKIPLLLC RLEAHSTCIN CIRWSSNSRY
LASAGTDQAV KIWRFVSYIP NVQSRVTAVE HWKCISTLHG HAGDVLHLSW SPGDRYLASC
GIDNIIIIWN AKKFPEKITS LVGHEGFVKG VCWDPIGKYL ASQSDDKSLR IWSTVDWNVV
HKFRRPFKEA PCATHTLRLD WSPDGLLLAT AHAVNNGGPV SKIIERNGWK CELDFAGHRM
AITCVRWSNV LYHRNRKVFL TEKSNVCSCC AIGSKDRSLS VWSASENRPI VVLTDIFESS
ISDISWDSSG LILIAASVDG SVVCLVWTTD ELGVPLSLDE KINKLRRYYG NVDVGLLGLQ
RKSDQNSHKI IEDADYVMTH AKVIANRSNE NGVNGGVCAS TAAVRTAPPP STPDTNWNVQ
LETRTKSGKR RITPINVEVV AEVDTDNNSQ PPWIREGVGL DVAGNAKGLT DEKMTVIDNA
ERWSGLNSTT VEPLVASFSS VSASKSTLAK SRKGDNFDAG GKSILKSSED HSGGIVEEFL
KKSKSELKFD KKKSWHQKGK KALKHAQRES TISQTFPSSG TEVEVETDFQ THQTVAVSSS
SKQKTPTHRL EALKVVQLLM SSVVVDESES EVLLQLSNNI GSKPKGKFAE LLCMKNSNCV
WKILLETGAV ALKANRHLIL VVFENGMFDI LSPLDGRMMC LTNVLGDSVH YVNLDGKLIA
LVTVCAELYV WSFVKSLELV CQVSLKALLR DPKRNLSRIV FSADGMPIIS FNDGSLFIYD
ASSKIWQKLL NPSDSFIKYS PTSMLASTKA YLKTKGRFQN LCKNLFSSVT FTAESDSEMQ
ERIREGFLER FSLASRAVGS EHEYMYWLSE YVKLLVKAES EVKLRCLFRT LVEIDEHMKT
NSMLSRDKSE KRSAVTDLLP LVAANPKLQR LYSELSFLVA EKSSNEQADD LYSEIAATAT
NSLKLSCDVM SVEKFMKSAP EEKSSHMSMA VILLNKMNKR CVGYVLKSDK DSSSGSRFIL
TTRTCSAKQI NAPIYILPEN KERHVKAIHT RGFHESLAVI EMQDKYAFKL ASESTCPLEF
PEISEECFTV YAVESQVNKR DIVAEPYKSS PKSSCEKYWI TFSEESFACA ATSQKEKRNG
LGLVCSQGGK LALVGISSEN QQTTSVTSFT LLYPYAKHFW KMSCNVLQQK MKLHEINSIT
ESSAVNDQEL KSGTELDLLS KWFTFIYPSE V
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