ID A0A0V0WM31_9BILA Unreviewed; 868 AA.
AC A0A0V0WM31;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Chloride channel protein {ECO:0000256|RuleBase:RU361221};
GN Name=CLCN4 {ECO:0000313|EMBL:KRX76822.1};
GN ORFNames=T06_2539 {ECO:0000313|EMBL:KRX76822.1};
OS Trichinella sp. T6.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=92179 {ECO:0000313|EMBL:KRX76822.1, ECO:0000313|Proteomes:UP000054673};
RN [1] {ECO:0000313|EMBL:KRX76822.1, ECO:0000313|Proteomes:UP000054673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS34 {ECO:0000313|EMBL:KRX76822.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004337}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU361221}.
CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC {ECO:0000256|RuleBase:RU361221}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX76822.1}.
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DR EMBL; JYDK01000093; KRX76822.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0WM31; -.
DR SMR; A0A0V0WM31; -.
DR STRING; 92179.A0A0V0WM31; -.
DR Proteomes; UP000054673; Unassembled WGS sequence.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:UniProtKB-UniRule.
DR CDD; cd04591; CBS_pair_voltage-gated_CLC_euk_bac; 1.
DR CDD; cd03684; ClC_3_like; 1.
DR Gene3D; 3.10.580.20; -; 1.
DR Gene3D; 3.90.1280.20; -; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR PANTHER; PTHR45711; CHLORIDE CHANNEL PROTEIN; 1.
DR PANTHER; PTHR45711:SF6; CHLORIDE CHANNEL PROTEIN; 1.
DR Pfam; PF00571; CBS; 1.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SMART; SM00116; CBS; 2.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
DR PROSITE; PS51371; CBS; 1.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Chloride {ECO:0000256|ARBA:ARBA00023214, ECO:0000256|RuleBase:RU361221};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Ion transport {ECO:0000256|RuleBase:RU361221};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361221};
KW Reference proteome {ECO:0000313|Proteomes:UP000054673};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361221};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361221}; Transport {ECO:0000256|RuleBase:RU361221}.
FT TRANSMEM 152..173
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 185..209
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 273..298
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 319..341
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 375..399
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 411..428
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 449..470
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 490..509
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 555..575
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 581..605
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 626..653
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 659..676
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT DOMAIN 801..862
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
SQ SEQUENCE 868 AA; 96197 MW; 0795CD5C45DBD86F CRC64;
MIVKNRLPSR KSHPIVTQSP PRIASTMPPF FLGLLMSETD LLLYKGVKKY STPSSRIMAT
EIQENGSFGP SGTRAIGLKN MKEDDADTSV SYDVPANLDC EEPLPIVLSQ YEDFHTIDWQ
RDLARDRLRH KFIKKKNRES MTSCITGLVD AGSGWICVLF VGLTAVNIVR FIGGNGVKQE
AYTVLLFNDS IFLFVLKCLH FHGVVAGLVD ISTRWMSDLK EGVCPDAFWF DREHCCWSAN
DTLFYGDKCN AWHTWPELFG HYSEDGLAYF VEYVFYTCWA LGLAGLAAIF VRVFAPYACG
SGIPEIKCML SGFVIHGYLG KWTLIIKTIG LVLAAASGLS LGKEGPMVHL TCCIGNILSY
LFPKYGKNEA KKREILSASA AAGVSVAFGA PIGGVLFSLE EASYYFPLKT LWRSFFCALI
AGLILKFINP FGTDQTSLFA VDYPMRWSYI ELIPFISLGI FGGVIGTIFI KCNICWCRFR
KSSTLGDYPI AEVLSITFIT ALLSFPNEYT RKSSSSLISH LFNRCGPEEI KYREVIGVTN
STSDISFGSL MNGTIWKLVL SLIFKIVITI FTFGMKVPSG LFVPSLAIGA IGGRLVGITM
EWLALDYRDA WWWGIYCEPG KVCVQPGLYA MVGAAAVLGG VTRMTVSLVV IMFELTGSLE
FIVPTMAAVM FAKWIGDAFD RRGIYDAHIA LNGYPFLDNK EEFTLNSVAA DVMRPRPGDM
PLRVISQEGM TVGDIEELLR LTDHNGFPIV VSEDSPNLIG YVTRPTARKN QEGIVTDSLV
YFSSNAPVDP EGPGRPVPLR LRKLLDLAPI SITDQTPMET VIDIFRKLGL RQLLVTHMGK
LLGIVTKKDV LVHIKELENE DTSTMLFI
//
