ID A0A0V0WM56_9BILA Unreviewed; 854 AA.
AC A0A0V0WM56;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=ATP-dependent RNA helicase DHX8 {ECO:0000313|EMBL:KRX76845.1};
GN Name=DHX8 {ECO:0000313|EMBL:KRX76845.1};
GN ORFNames=T06_10772 {ECO:0000313|EMBL:KRX76845.1};
OS Trichinella sp. T6.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=92179 {ECO:0000313|EMBL:KRX76845.1, ECO:0000313|Proteomes:UP000054673};
RN [1] {ECO:0000313|EMBL:KRX76845.1, ECO:0000313|Proteomes:UP000054673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS34 {ECO:0000313|EMBL:KRX76845.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX76845.1}.
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DR EMBL; JYDK01000093; KRX76845.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0WM56; -.
DR Proteomes; UP000054673; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0022414; P:reproductive process; IEA:UniProt.
DR CDD; cd21691; GH2-like_DHX8; 1.
DR CDD; cd05684; S1_DHX8_helicase; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR049588; DHX8_GH2-like.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR049621; S1_DHX8_helicase.
DR InterPro; IPR003029; S1_domain.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF85; ATP-DEPENDENT RNA HELICASE DHX8; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00575; S1; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00316; S1; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50126; S1; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000313|EMBL:KRX76845.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000054673}.
FT DOMAIN 241..311
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 558..723
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 741..854
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 78..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 135..226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 306..329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 457..499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..174
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 195..226
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 854 AA; 96499 MW; B92C89DEAE006923 CRC64;
MEEMERLQYI SLVSKICTEL ENHLGLSDKD LAEFIIHLGQ KNPTFESFKS ALESNGAEFD
NSLISNLLRR IQLMTKPTGK SEDAAENASH MLSMSSKSDR EVMKQCLPAL AMPNKPVSET
LSELENLIPQ WRRENEIEQK ANTGHGSRDE RKKRERLHSR DRSSSCDSSE RRAERRRARR
RRSSSFSGES SKKHSSRGGR RRRSRSRSEL RTKGVHSRRR SRSGERISRI RIKLDDTPTV
GKIYDGRVNS LRDFGCFVEL FGLRRHVEGL VHISQMKDER VNAVSDVVTR GQKVKVKVLA
SSGNRTSLSM REVDQETGED LNPTEDVDQD DQHFDETLQL RNPDLPSAAQ QKLMQLQAEE
FKASTSKRTK RLSSPERWEL KQMMAASCIS TADLPDFDEE TGVLLQEDML DDHEEDVEVE
LVEEEPQFLQ GYGRVRQDLE PIKVVKNPDG SLAQAAMMQG ALAKERREQK IQQQRERGNE
QQLGRGSGSG GRSFLDPLAD GDSKYSKVLQ NVERKHMDLP EWKRHIAAGK SFGKPQGSMT
ILEQRQSLPI YKLRSELVKA VSENQILIVI GETGSGKTTQ ITQYLAEEGF TFSGKIACTQ
PRRVAAMSVA KRVAEEYGCR LGQQVGYTIR FEDCTSPDTN IKYMTDGMLL RECLLDPDLN
AYSVIMLDEA HERTIHTDVL FGLCKQAVKN RGADQLKLIV TSATLDAVKF SQYFNEAPIF
TIPGRTFPVE VLYTREPETD YLDASLITVM QIHLTEPPGD ILVFLTGQEE IDTACEVLYE
RMKSLGPDVP ELIILPVYSA LPSEMQTRIF ESAPPGSRKV VIATNIAETS LTIDGIYYVV
DPGFVKQKVL LLFI
//
