ID A0A0V0WZI0_9BILA Unreviewed; 1053 AA.
AC A0A0V0WZI0;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=mcm5 {ECO:0000313|EMBL:KRX81168.1};
GN ORFNames=T06_6097 {ECO:0000313|EMBL:KRX81168.1};
OS Trichinella sp. T6.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=92179 {ECO:0000313|EMBL:KRX81168.1, ECO:0000313|Proteomes:UP000054673};
RN [1] {ECO:0000313|EMBL:KRX81168.1, ECO:0000313|Proteomes:UP000054673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS34 {ECO:0000313|EMBL:KRX81168.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MCM family. {ECO:0000256|RuleBase:RU004070}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX81168.1}.
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DR EMBL; JYDK01000034; KRX81168.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0WZI0; -.
DR Proteomes; UP000054673; Unassembled WGS sequence.
DR GO; GO:0042555; C:MCM complex; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0032508; P:DNA duplex unwinding; IEA:InterPro.
DR GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR CDD; cd17756; MCM5; 1.
DR Gene3D; 2.20.28.10; -; 1.
DR Gene3D; 3.30.1640.10; mini-chromosome maintenance (MCM) complex, chain A, domain 1; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR008048; MCM5.
DR InterPro; IPR018525; MCM_CS.
DR InterPro; IPR001208; MCM_dom.
DR InterPro; IPR041562; MCM_lid.
DR InterPro; IPR027925; MCM_N.
DR InterPro; IPR033762; MCM_OB.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1.
DR PANTHER; PTHR11630:SF42; DNA REPLICATION LICENSING FACTOR MCM5; 1.
DR Pfam; PF00493; MCM; 1.
DR Pfam; PF17855; MCM_lid; 1.
DR Pfam; PF14551; MCM_N; 1.
DR Pfam; PF17207; MCM_OB; 1.
DR PRINTS; PR01657; MCMFAMILY.
DR PRINTS; PR01661; MCMPROTEIN5.
DR SMART; SM00350; MCM; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00847; MCM_1; 1.
DR PROSITE; PS50051; MCM_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004070};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004070};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004070}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000054673};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 801..820
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 884..905
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 936..954
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 975..995
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1015..1034
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 332..537
FT /note="MCM"
FT /evidence="ECO:0000259|PROSITE:PS50051"
SQ SEQUENCE 1053 AA; 119540 MW; E24E760E19E3F520 CRC64;
MSGFDRAEIQ YSGQDEQKRL ELALTEEGTL KFAKSKFKNF IREFNYGSFA HIYRESLRNH
CKLGKMYLEV RLQDMRSYNS DLAYIFQKNP TEVLPMFEEV TKDVAEETTY QGSSEVNTLP
NMQVIITSDE NSQPVRSLQS KQISKVVKLR GIIVSTSQVR CKATEISIQC RNCQLTVNNI
SMQPGFDGYA LPRRCNSNQI GQQQKCPVDP FVILPDKCRC IDFQVLKLQE CPEDVPHGEL
PRHMVLYCDR YLTDRVAPGN KVSVLGIYCI RKQHKMTRRE KAGKPSAGLR QPYIRVIGIE
VESSGLGRTA PHALLSPEDE KQMRELAAQP DIYERIAKSI APSIYGSEDV KKAIACLLFG
GSRKRLPDGL MRRGDINVLL LGDPGMAKSQ LLKFVEKVSP IGIYTSGKGS SAAGLTASIV
RDASSRSFVM EGGAMVLADG GVVCIDEFDK MREDDRVAIH EAMEQQTISI AKAGITTTLN
SRCAVLAAAN SVYGRWDATK GEDNIDFMPT ILSRFDTIFV IRDVHSETRD LALAKHVISV
HVGADSEAVR DEEATDGEIS LATLKKYIAF CRTRCGPRLN RSATRKLIHS YTRMRNVPVA
QQQKDLHIAY QKSSIPITVR QLEALIRIAE ALAKMELSPY ATDRHVDEAL RLFQVSTLAA
ASQGTLSGVE GFSTKEDQEQ FIRIERQIRK RFPVGTQVAE HVVIQDFITQ GYQEATIRKV
IYAMVRRGDL HHRLQRKMLY RKSEMMEKSF YKVNVTDHFE LPMQSASFVT IVRQVGGVLT
ISAVTFIEAV FLSRRRFNAE MILLAAYFFA LQLNGIGYLL NGIRFSNLRK RNYFPMVPVK
ECLLTHPDVT LSYFNYTLRP FLLVYLAVDR MCAVLLEVKN MKKVTTYGVI SVYVLSLFYV
IGAWIETFLL RSDCMIKQNC IYWSAVPWYH QKFQKYIHIF GLFAAVAIVI MALLRAYVKR
RKEVHCTTWS FANDYLAVTS RLSIIVFSEF IFRGLPLLWG CFVTRTISMY TVRMTLYVFS
DIIEAFYGVL YCYINKDLRE SIVSLCRLFG GCT
//
