ID   A0A0V0XUB2_TRIPS        Unreviewed;       943 AA.
AC   A0A0V0XUB2;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Retinoblastoma-like protein 1 {ECO:0000313|EMBL:KRX91633.1};
GN   Name=Rbl1 {ECO:0000313|EMBL:KRX91633.1};
GN   ORFNames=T4E_900 {ECO:0000313|EMBL:KRX91633.1};
OS   Trichinella pseudospiralis (Parasitic roundworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=6337 {ECO:0000313|EMBL:KRX91633.1, ECO:0000313|Proteomes:UP000054815};
RN   [1] {ECO:0000313|EMBL:KRX91633.1, ECO:0000313|Proteomes:UP000054815}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS141 {ECO:0000313|EMBL:KRX91633.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the retinoblastoma protein (RB) family.
CC       {ECO:0000256|ARBA:ARBA00009475}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRX91633.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; JYDU01000132; KRX91633.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0V0XUB2; -.
DR   STRING; 6337.A0A0V0XUB2; -.
DR   Proteomes; UP000054815; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051172; P:negative regulation of nitrogen compound metabolic process; IEA:UniProt.
DR   GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   CDD; cd20548; CYCLIN_RB-like; 1.
DR   Gene3D; 1.10.472.140; -; 1.
DR   Gene3D; 1.10.472.10; Cyclin-like; 2.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR002720; RB_A.
DR   InterPro; IPR002719; RB_B.
DR   InterPro; IPR028309; RB_fam.
DR   InterPro; IPR024599; RB_N.
DR   PANTHER; PTHR13742:SF36; RE32990P-RELATED; 1.
DR   PANTHER; PTHR13742; RETINOBLASTOMA-ASSOCIATED PROTEIN RB -RELATED; 1.
DR   Pfam; PF11934; DUF3452; 1.
DR   Pfam; PF01858; RB_A; 1.
DR   Pfam; PF01857; RB_B; 1.
DR   SMART; SM01367; DUF3452; 1.
DR   SMART; SM01368; RB_A; 1.
DR   SUPFAM; SSF47954; Cyclin-like; 2.
PE   3: Inferred from homology;
KW   Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054815};
KW   Repressor {ECO:0000256|ARBA:ARBA00022491};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          64..208
FT                   /note="Retinoblastoma-associated protein N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM01367"
FT   DOMAIN          379..568
FT                   /note="Retinoblastoma-associated protein A-box"
FT                   /evidence="ECO:0000259|SMART:SM01368"
FT   REGION          773..805
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          924..943
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        791..805
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   943 AA;  107372 MW;  BE652FA96DB5C821 CRC64;
     MEGTSEENLE LQFRELCKSL SLGDARIDIA WRGFEAVRRQ CLLSDDPMKW LACSVYVACW
     LCSSSVASPA DRKALPVDIM KTFNVPIVQF FDSIVKWVDM ANMTPRSYQH VVRLENSFAV
     STVLYSRFLS IFSKLFFTDD LKTGSADGEY STPCKKLKSN DDPVTSESLK EFAWLLWIYI
     RKSIGGISDN LIHGFNLLLC MFDTVISNVS LLEEKEFFKV DSLPTCDGRL LDGLCLKFDA
     VVMDVKFARA EWWAPKLQAL IASSILKGDS KVFTSLLVAE NFRFNLDSLH RHYEELLLKK
     GDLDERIFLN EVDYSLLQSA AKKKSPSRTP DKSESTSHAE FCLSLVKPVV MRTPLSCRYP
     PKQQDDLLLV DGDNPRVSEP VAALQAMIDS YRDVRDGFLR IAFSQVTPNP MCYVFSLMDA
     MGEEFINAYK LLSKDADDLE HSLAVAVQRR HCADGLFQRL LTKIVRTERN RSSILDLSEA
     IVHEEFVFSL YAVCVELVLF TYGSGDLFPW AMENVVHQTP FHFYKVIEVV IKNEKELSRD
     CVKHLNIIEE RILEELVWEE SSPLWTETGE CRVPSSVEIS SKSPRIMHYY RPVQKFAFAR
     NGRSICRRLE MNRTSSIRFN STVGRPTGGA SEHMIKISTV NVAKKPITVP ASELTNQEKS
     QTVAEETRSP SSTITMFFKK LYYLISIRLN DLCDRFRVAE NVKLQTWALI ERVLCSHMTL
     LKGRHLDQII MCCLYAMSKA THNEALFKDI ISIYRGQPQA KSRVYRCVRL DPTTKTGKNK
     DDDDDDDEAV AQQQQQQQQQ QHAITSHAEY GDITEFYNRN FIDAVRGDIA SMLQSDSEGG
     ESTPPVSPFP TNRLMSVTKK SVTCGIYLSP LKVVPPVHSS PIRPMRYSFY RSSIRELKMI
     NTMMDSTSER GVERVGPPVR RALFGRGAPE PTQRKWARPS TNL
//