ID A0A0V0YBX1_TRIPS Unreviewed; 1625 AA.
AC A0A0V0YBX1;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Sodium leak channel non-selective protein {ECO:0000313|EMBL:KRX97873.1};
DE Flags: Fragment;
GN Name=NALCN {ECO:0000313|EMBL:KRX97873.1};
GN ORFNames=T4E_1933 {ECO:0000313|EMBL:KRX97873.1};
OS Trichinella pseudospiralis (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6337 {ECO:0000313|EMBL:KRX97873.1, ECO:0000313|Proteomes:UP000054815};
RN [1] {ECO:0000313|EMBL:KRX97873.1, ECO:0000313|Proteomes:UP000054815}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS141 {ECO:0000313|EMBL:KRX97873.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX97873.1}.
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DR EMBL; JYDU01000026; KRX97873.1; -; Genomic_DNA.
DR STRING; 6337.A0A0V0YBX1; -.
DR Proteomes; UP000054815; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005261; F:monoatomic cation channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 3.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR028823; NALCN.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR46141:SF1; SODIUM LEAK CHANNEL NALCN; 1.
DR PANTHER; PTHR46141; SODIUM LEAK CHANNEL NON-SELECTIVE PROTEIN; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054815};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 58..80
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 176..198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 261..282
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 294..315
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 384..406
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 453..477
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 753..777
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 797..820
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 832..849
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 894..913
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 978..995
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1007..1034
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1093..1111
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1123..1149
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1161..1179
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1191..1208
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1229..1253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1317..1340
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 14..207
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 260..484
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 758..1039
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1088..1351
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 622..643
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KRX97873.1"
SQ SEQUENCE 1625 AA; 188771 MW; AA53D45946F0EEEC CRC64;
LLLYFLPNLF PNAEHIRLFG LLRAPRPLIM LRLIRSLLKI QLPRNRISQI FKRSSQQVYN
VTIFFLFFMS LYAILGVQLF GRMDYHCVKN GTDPKNVSIR DLAIPDTYCS PDTTGYQCPK
GMECIRLKLT DSIEGYYGMF NDFAHSVFSV YMAASQEGWV YVMYDCIDSF PSWKTFLYFT
TLIFFLAWLV KNVFIAVITE TFAEIRVQFS QMWGNREMMT EVEIRQILEK KEESWRLIAM
DAKQSKGWAP KICQDFYSST VFQIIIMILV LSNAFIHASF VHRHDGTDWF RKQIYYYIEC
GFTLIFNLEC LFKVWCLSWK GYISRGLHKF EFILCVGSTL NIIKPLYDMN VFTYCQVFRV
LRLIKASPML EDFVYKIFGP GKKLGGIILF TISLLLLTSS ISLQLFCFVN NLDMFRTLPQ
AIMSMFQIMT QEEWIEVVVE TMRAVGDTLA PLVAIYFVTY HLLVTLIVLS LFVAVILDNL
EMDEELKKVK QLKAREHTTS SRNKLPLRLR VFTHFPDRPQ MVTVKRIPSE FPLPKIRDSF
TKQYANDDQE ELEDEREKSR TYNYRVPNDG IKKLRARKQT KIRQIGHLSA ITGVSYVLND
SNKTRLMLSD SYGILPTSNL ISNRKPSSFE SRNRKNAKPP GGTKIKQIYQ HLKENGDLFS
PDDLSEKKEK SQGEIDIKAI QQKKRQAEMA RSRLEEEMKE NHPYFDKPLF VLNREHKIRK
ICQLIVYSKY MPTKTDPITQ KPVLRKHQEI HELFGMMTYL DWTMFFLTCV SCISMLFEKP
WPLDGRHLIM NNGYLQIAEY LFVIGMTFEL LLKILANGLF FTPKAVIRDA GGVLTAFIYI
TSLIFLIWMP KHVQPNSGAQ LFMIFRAMRP LRIYTLVPHI RRVVVELFKG FREILLVTIL
LVVLMFIFAS YGVQIAGGKL AKCNDLTIKT KEECVGYFYQ YVHVTKLKIP GQGDPDLHPK
LLVPRLWANP RNFNFDHIGN AMLALFEILS FKGWTVMRDV ILDRLGAWAA IFVHIYVFIG
CMIGLTLFVG VVIANYSENR GTALLTVDQR RWNDLKSRLK MAQPLYVPPR PPESSKIRKF
LYDLSMSQYF KRFFTICVLL NSMLLFVPWS VEEEEHPETK ETLKALIALS AVFTLLFAVE
IICKVIAFTH RGFWQSVRNR IDLVITLFGL IWCLLHFFVA LPTEKKNLRE VTYLIGYSIV
VMRFFTIVGR HSTLKMLMLT VFMSMLRSFF IIMAMFLLML FYAYAGVILF GMVKYGQAVN
RHANFRSSSN ALAVLFRIVT GEDWNEVMHD CMRSPPYCWY FEGAAYWETD CGNYHGAIIY
FCSFYLTITY IVLNLLVAII MENFSLFYSS EEDALLSYAD IRNFQTVWNI VDKEQKGYVV
VRRVKFLLRL LKGRLEVDPE KDRLLFKHMC YEMEQLHNSD EVSFHDVLSM LSYRSVDIRK
HLQLEELVQR EELEYLIEEE VAKLTIRSWL EKCLRRMRQK EQNFSFINSL RAATAGLVEP
IEVPAVVEIN KADVSKKSVG SKLSQRSSLG NAIADTAKKL IPTAKSPFER GNGRSSSIKI
RPKPLTGVAE SIEDLKKETS DLQMSPLHSN ILNSTSSHSA AVLESEVYFE TIDVKEWWND
AIRCG
//
