ID A0A0V0YC46_TRIPS Unreviewed; 930 AA.
AC A0A0V0YC46;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 22-FEB-2023, entry version 21.
DE SubName: Full=SH2B adapter protein 2 {ECO:0000313|EMBL:KRX97802.1};
DE Flags: Fragment;
GN Name=Sh2b2 {ECO:0000313|EMBL:KRX97802.1};
GN ORFNames=T4E_10367 {ECO:0000313|EMBL:KRX97802.1};
OS Trichinella pseudospiralis (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6337 {ECO:0000313|EMBL:KRX97802.1, ECO:0000313|Proteomes:UP000054815};
RN [1] {ECO:0000313|EMBL:KRX97802.1, ECO:0000313|Proteomes:UP000054815}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS141 {ECO:0000313|EMBL:KRX97802.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the IWR1/SLC7A6OS family.
CC {ECO:0000256|ARBA:ARBA00010218}.
CC -!- SIMILARITY: Belongs to the SH2B adapter family.
CC {ECO:0000256|ARBA:ARBA00010220}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX97802.1}.
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DR EMBL; JYDU01000027; KRX97802.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0YC46; -.
DR STRING; 6337.A0A0V0YC46; -.
DR Proteomes; UP000054815; Unassembled WGS sequence.
DR GO; GO:0035591; F:signaling adaptor activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01231; PH_SH2B_family; 1.
DR CDD; cd10346; SH2_SH2B_family; 1.
DR Gene3D; 6.10.140.110; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR015012; Phe_ZIP.
DR InterPro; IPR036290; Phe_ZIP_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR030523; SH2B.
DR InterPro; IPR035057; SH2B1_SH2.
DR InterPro; IPR013883; TF_Iwr1_dom.
DR PANTHER; PTHR10872:SF2; LNK, ISOFORM D; 1.
DR PANTHER; PTHR10872; SH2B ADAPTER PROTEIN; 1.
DR Pfam; PF08574; Iwr1; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF08916; Phe_ZIP; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00233; PH; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF109805; Phenylalanine zipper; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000054815};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 524..630
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 765..869
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 220..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 220..254
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KRX97802.1"
SQ SEQUENCE 930 AA; 104204 MW; AB683E009950CF80 CRC64;
LLQRSGVCLD QTLCTIMSLP VLYRVKRQAD EKPFALTEIC SKKRRPDETS PPLSGDEPMM
LDSQLLNDLE SSIPSACLQK WKKLKLVDLK RSTTTTTGSD GGEGDEVNWM VDTVSLLDLT
ELRRKSRKQY TTDEDENEGG SIEDYIKQLS FSEKKQNNFQ NKITCNDVIM ERTTLEDRFL
WSRIDDSEGL AYDYLFLPSK EESPVQPEDE NICLWEGEVD DNDEDEDSED SNAENYYTND
YPEEEEEEGE EYYEADDRDS IKSKGEASKV GAAAAAATAT TTTTEQENFS FWLAIISSSG
YPSTMISTNQ QKNVELLNGG TVLQANVAEP RASLVWTEFC ESCAKFAAYD FAQSWRNYLT
LNPQMIDRVS EQEAAAKFVQ AFGSYFENEA RRICRSSRLL NESIISCGSH ILPPEPGTSR
NGAPAQYVNS LCSSETDSDS SLNDALSTDY DIKKKKNFFT RFSYKSVKRS FFKKQSSDET
VFAPGSSDCD PARNSLLLMK HRKKGKAGTG TGTTFLTTTK TVVEVVREGS VNFICGKELD
GESWEKGRMV LVKTAGGYLL EFYSPPKASK PKNGIFCFLI TEVRETTALE TPDSEHTFVL
KAENLKEYIV QAKSHKDMRS WLSVIRSCMD NSLCTENANT TSSERLSIIA NACTKTDSGY
RSGDFHSLPL RGSSGTRKTP HIRLSSLFTG RDLTGSSANH SHLASQLRRS YSSSQASHVN
MAVRQLHSSG SALLNSLRGL QMSTGAIHDN SCPYGILRML ENYPWFHGSL SRRDATNLVV
QCGVDGHGLF LVRQSETRTG EYVLTFNCYG RAKHLRITVL ARGHCRVQHL WFESIFDMLD
HFRSHHIPLQ TSARDNHSAN VGVMLLDYVI VWPPQQGPQI TTGPVDPRNY MTHGGSVRLT
TRSLEQLALE QNYQHPTAVH GRAENAYQFT
//