ID A0A0V0YDX6_TRIPS Unreviewed; 4947 AA.
AC A0A0V0YDX6;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Dynein heavy chain, cytoplasmic {ECO:0000313|EMBL:KRX98547.1};
GN Name=Dhc64C {ECO:0000313|EMBL:KRX98547.1};
GN ORFNames=T4E_10496 {ECO:0000313|EMBL:KRX98547.1};
OS Trichinella pseudospiralis (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6337 {ECO:0000313|EMBL:KRX98547.1, ECO:0000313|Proteomes:UP000054815};
RN [1] {ECO:0000313|EMBL:KRX98547.1, ECO:0000313|Proteomes:UP000054815}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS141 {ECO:0000313|EMBL:KRX98547.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Consists of at least two heavy chains and a number of
CC intermediate and light chains. {ECO:0000256|ARBA:ARBA00011655}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX98547.1}.
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DR EMBL; JYDU01000020; KRX98547.1; -; Genomic_DNA.
DR Proteomes; UP000054815; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR CDD; cd05371; HSD10-like_SDR_c; 1.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 1.20.920.60; -; 2.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002347; SDR_fam.
DR PANTHER; PTHR10676:SF314; CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF00106; adh_short; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 2.
DR PRINTS; PR00081; GDHRDH.
DR SMART; SM00382; AAA; 3.
DR SMART; SM00822; PKS_KR; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000054815}.
FT DOMAIN 1906..2043
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2591..2741
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2933..3099
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 1034..1090
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1292..1322
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3212..3271
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3470..3525
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4947 AA; 567155 MW; 304D95D6E0199196 CRC64;
MVDNINEAIV DVSSPTVEIA QVELAEARVF SLFVRRIILL LLEDASGEPC GDAYATALDE
CLHRTDTVDV FRRFIADAQA PALLIERSCE RDSEETADAT EITEIVNYTV STEVHFSSPK
TNGLILIKRG AVLEADKPLI QQLLLFILAD ASPYETLHSY FSTTICPYFK SFVKESGGGD
NYRDTDKAAM SVEKKLIELE MGLLHLQQNI DIPDITLLIH PVVQSVIKQA AEENRRAKVS
DFGKLVDDST FLNQLQNGVT RWVREMQKVT KLDRDPSSGS ALQEITFWRN LERAVFNLLE
KRESPEVILT LEVLKHGKRF HATVSFDTDT GLKQALDTVT NYNVLMKDFP INDLLSAVEM
DRIRAAVASI FIHLRKIRTS RYPIQRCLRL IEAISRDLQI QMLKVLGMRR ILQISFDEFD
KVMTQAFEVF TCWDDEYEKL QALLRDLLKK KREEQLKLIW RIVPAHKKLQ FRLEEIRRFR
RHHEQLRAVI VRVFRLTSTL HGNENDHTFD ESPRMYDAAD TSVVEEVNVA YDFVKDIDCL
DLSKEGSDSW SSALKCYEER IDRVEGRIAT RLRDQLGSAK NANEMFRIFS QFNALFVRPH
IRGAIREYQT QLIERVKDDI EALHERFKKQ YSHSKACSTS SIYDIPPVSG FVIWAKQIER
QLALYLRRVE DVLGKGWENH IEGQALKTDG DIFRAKLNTQ PVFDEWVTKV QTRNLGLSGR
VFVVESVRRR NDSKASLRLR VNFLPDFITL AKEVRNFKNL SFRVPLAIVN KAHQVNQLYP
FAMSMIESVR TYELMTERLN EKENVAILLA GLVKEIHAQI AEGAGLVWES YKLDSYVQKF
SEMISHFQER VEELLHLEEQ IKIQLNLLDT CQYAAPAFQQ ILSNIQKSVD ALSLYQYSNL
DIWIKRLDEE IEQKLAIRLE EGIKSWIRAL KGEIDEENSS SEDLSAQSKF KVGGDPIIHS
FVHEIRITQQ VMYLSPCIEE IQVNLLQQLF SWEAIVTSQA RISSSCYHVE IERSSALTKY
RSLLAKLPHG IKYIEKAYAA IENLKIEVKD YVNEWLRYQA LWDLQADTLY DRLNTDLSKW
MKTLQELKEA RSTFDTSETR KQFGVIVVDF ARVQSKVSLK YDSWHKEILQ RFGTILGNEM
QSLYTVVNKA RTHLEQQSVD ISSTSEAVSF ITYVQNLKRN VLDWDDKVEC FREGQRILER
QRFQFPSNWL YSENFDGEWS AFSDILSRKS TAIQSQVNTL QAKIRQEATA VETRSADXXX
XXXXXXXXXX XXXDFSSTII GDQLPDVALQ TLVVYEGKLS RLKEERDNIS RAREALELQE
TSHTSVHGER LKAAIEELND LKQVWQALNP LYNELAEIKE RLWLSVQPRK LRQNVDSLLN
QMKEMPANYR NYDAYDHLKR LLQSYAKINF LIVELKSDAL KSRHWKQLMS LLHVHWNLNE
LTIGQIWACD LQRYESSIKE IILVAQGELA LEEFLKQLRE FWQTYELELI NYQNKTKLIR
GWDDLFNKLK EHINSLNAMK LSPYYKEFEE DCLVWEEKLN RITALFDVWI DVQRRWVYLE
GIFSGSADIK TLLPTETSKF QSISSEFLGI MKKVSMSARV TEILNVPGIQ RLLERLADML
NKIQKALGEY LERERSEFPR FYFVGDEDLL EIIGNSKNIP RLQKHFKKMF AGVACILFNE
DYTLIHGVAS REGEEVNFLH SISIKETPRV NEWLGLVEKE IQNTLAQLLV TCLQEFQKFK
VHPIDADSYY NWLDKFPLQV ITLAAQIAWS EDVELALGKN ANLESILKFV ENTLNLLADS
VLHEHPPLRR KKIEHLITEF VHKRCIMRYL MDCGVNSNQS FYWLKQMRFY LNADEVDPQK
KLTIRMANAQ FYYGFEYLGI QEKLVQTPLT DRCFLTMTQA LESRLGGSPF GPAGTGKTES
VKALGNQLGR FVLVFNCDEN FDFQARRIFI GLCQVGAWGC FDEFNRLEER MLSAVSQQIQ
AIQETLRLTQ TKNDASVELL GKRVWVSPQM AIFITMNPGY AGRSNLPDNL KQLFRSLAMT
QPDKQLIAEV MLFSQGFRLA EKLASKIVPF FTLCSEQLSN QTHYDFGLRA LKYVLVKAGN
VKRDHVQQLK EQFQQVDRSF SEGVIGEQLP EQEILIQSVC ETLVPKLVAE DIPLMFSLLS
DVFPGIPHTK AEMKRLREEI RKVCRERYLC YSEVEGELGY TWAEKVIQLY QIVQLNHGLM
MVGSSGTGKT KAWQVLLAAL GRVDGVDGAV HVIDPKAITK DALYGTLDPN TREWTDGLFT
HILRKIIDNV RGESTKRQWI IFDGDVDPEW VENLNSVLDD NKLLTLPNGE RLALPQNVRI
MFEVENLKYA TLATVSRCGM VWFSADCVTE EMCFENYLQK LRNVSLDAHE NSGMPVSNLP
VTQAQTNLTD QILPSLQVQR DIANILAPYL SSDGLVARCL EFAENQVEHI MEFSSCRALS
SFFSMISQCI MKILFYNQQH SDFPMAFDQM ERYITRSLLL SIVWSFVGDA RAKYRDDMCE
MIRSLTAIAL PAQENVSLIE FEVSVDGEWS SLHNRVPQVE VESHKVGAPD VVIPTIDTVL
HEQLLYTWLA DHKPLVLCGP PGSGKTMTLF SSLRSLPDME VVGLNFSSAT SPELLLKTFD
HYCEYKRTPN GIVLSPVQLG KWIVLFCDEI NLPNYDKYGT QRVISFLRQM VEHGGFYRSS
DQAWVTVERI QFVGACNPPT DPGRKPLSQR FLRHVPVVYV DYPGELSLKQ IYGTFNRAML
RMIPSLRSFA EPLTAAMVEL YLLSQDRFTP ELQPHYVYSP RELTRWVRGI CEAIRPLETL
NVESLVKLWA HEALRLFQDR LAEEDERRWT DEQIDLIAAK HFPNVDVSVV LRRPLLYSCW
LTKDYLPVER EELRNFLQAR LRVFYEEELD VRLVFFDEVL DHVLRIDRIF RQPQGHLLLI
GVSGSGRATL SRFVAWMNGL SVFQVKIHNK YSAENFDDDL RLVLRRVGCK GEKLCFIMDE
SNLLDSSFLE RINTLLANGE VPGLFEGDEY TTLMSQIKEA SQHEGLILDS SEELYRWFTQ
QVMRNLHVVF TMNPSSEGLK DRVSTSPALF NRCVVNWFGD WSKSALFQVG RELTSNLDMD
NTAYRSPDYF PYACDLVSRP PTYREAVVNA YVYVHETLHQ VVLQLTKRDH RTVLITPRHF
LDFINHYVKL FHEKRKDLVD QQRHLNIGLS KIVETEQQVT ELQKSLSLKS KELEEKNALA
NEKLKQMLSN RQEAENQKHM SEQIQSNLQQ QLAEVAAKKS DVMKQLAQVE PAVIDAQNAV
KSIKKQHLVE VRSMANPPGL VKLALESICL LLGENCTEWK LMRAVIVKDD FISRIVNFDT
DSVTNIRRQH LGEIRYLSSP PATVKLALEA VIFLFTGSST LDWKSIRGYL LRDDFVSQIL
NFDTERITED IRQKMKAKYL DNPEYNYEKV NRASQACGPM VKWATAQINY AEMLHKVEPL
RNELKKLEND AEVNKRKVED VNAVINQLEK SIASYKDEYA LLISEVQSIK ADLIAVQTKV
DNEISFYKTC YFDQQIRLSL FMNWSRHLDE AGIQFRPDIS LVEYLANPDE RLRWQQHALP
VDELCVENAI MLKRFTRYPL IIDPSGQAIE FLMQEYGERK IIRTSFMDDA FRKNLESALR
FGNSLLVQDV ECYDPILNPV LNYEVKRAGG RVLITVGDQD IDLSPSFQIF LSTRDPTIQL
TPDICSRVTV INFTVTRSSL QSQCLNHILK AERPDIDSKR SDLMKLQGEF ALRLRHLETS
LLQALNDVKG RILDDDSIIS TLETLKKEAA EVSRKASETE TVMMEIEKTS QLYTPFSSYC
ASLYFTLDHL NQMHFLYQYS LQFFMDIFMH VLNKKSILDG ISDYSQRLNV ITKNIFKTVY
KRVSLGLLHH DRLGFALLLS RIYLKGMSES DCSFDDEFSH LLMKSDSLKT ADTTPFSISG
QLKLSKEQKE KLAQLVVTLP AFASLAERLT QTEGVLEWME SSNPEINCPI LWDESKTTTP
VSQALYRLLL IQALRPDRLL SAAHMFIDVA FGENFMSTGE NILNLKTIVE NEISCNMPLL
LCSVPGYDAS GRVDDLSSEL DRGLTSIAMG SAEGFDAAEK AVNSSAKTGR WVLLKNVHLA
TGWLIHLEKK LHSLVPHPNF RLFLTMEIHP KLPVNLLRAG RIIVYEPPPG IKANLLRTFG
TIPPGKMTKP PAERPRLFFL LAWLHALVQE RLQYVPLGWT KKYEFSEADL RAAWECVDTW
VDAAAHGRAN LPAEKVPWNA IRTLLSQCIY GGHLDNEFDQ ILLDCFIEKL FSEKSFQPDF
ALVNNVDSFG NKLTVPDGVR REQYVNWVES IQALQSPTWL GLPSNAEKVL LTIRGQTMVK
KLLKMNDEDE ELAYTPIGEQ FEGENHKPHW LKQIREAADH WLNSLPTSLA PLKRSVSNIK
DPLYRFFERE VNIASRLLNN VRHDLADLIS IVEGNKKPTN HHRDLFAHLN KGLVPETWIK
YTIPSTTTIT QWVHDFAERL AQFQLIVDAI SSGRIKNLKN RLWIGGLLSP EAYLTATRQH
VAQLNEWSLE ELKLDVQVAN NFDNLEMDDC SFGVTGLKIM GVSCSEQGRL KISPKIWTDL
LAVQLRWVHG MGAEKQKLNN TVRLPVYLYT DRQRVLFSLD FQTDPAVSSV NEFYERGVAI
VCSGLMQMVL AKSRNLVALI TGGASGLGKG CAEQLLKMGS KIVLMDLPTS SGAEVANSLH
KTDVVFSPGD VASESDVSKT LEFCRQKFGK LDAVVNCAAI GIAFSIYNNT KKQPHPLEPF
ESVFRVNVLG TFNVIRQSIG MMLEKELGED EERGVIIMTS STAAFEGQQG QAAYAACCGA
LNSMTLPLAR DCSRHRIRVV TIAPGLFDTP LTSFLPEKVQ QFFGRLTPYP HRFGQPAEFG
HLVQSVIENP MINGEVIRID GGLRMPP
//
