ID A0A0V0YEE9_TRIPS Unreviewed; 2322 AA.
AC A0A0V0YEE9;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 22-FEB-2023, entry version 20.
DE SubName: Full=Pre-mRNA-processing-splicing factor 8 {ECO:0000313|EMBL:KRX98336.1};
DE Flags: Fragment;
GN Name=Prpf8 {ECO:0000313|EMBL:KRX98336.1};
GN ORFNames=T4E_2907 {ECO:0000313|EMBL:KRX98336.1};
OS Trichinella pseudospiralis (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6337 {ECO:0000313|EMBL:KRX98336.1, ECO:0000313|Proteomes:UP000054815};
RN [1] {ECO:0000313|EMBL:KRX98336.1, ECO:0000313|Proteomes:UP000054815}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS141 {ECO:0000313|EMBL:KRX98336.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX98336.1}.
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DR EMBL; JYDU01000022; KRX98336.1; -; Genomic_DNA.
DR Proteomes; UP000054815; Unassembled WGS sequence.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR GO; GO:0030623; F:U5 snRNA binding; IEA:InterPro.
DR GO; GO:0017070; F:U6 snRNA binding; IEA:InterPro.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR CDD; cd08056; MPN_PRP8; 1.
DR CDD; cd13838; RNase_H_like_Prp8_IV; 1.
DR Gene3D; 1.20.80.40; -; 1.
DR Gene3D; 3.30.420.230; -; 1.
DR Gene3D; 3.90.1570.40; -; 2.
DR Gene3D; 3.40.140.10; Cytidine Deaminase, domain 2; 1.
DR Gene3D; 3.30.43.40; Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain; 1.
DR InterPro; IPR000555; JAMM/MPN+_dom.
DR InterPro; IPR037518; MPN.
DR InterPro; IPR012591; PRO8NT.
DR InterPro; IPR012592; PROCN.
DR InterPro; IPR012984; PROCT.
DR InterPro; IPR027652; PRP8.
DR InterPro; IPR021983; PRP8_domainIV.
DR InterPro; IPR043173; Prp8_domainIV_fingers.
DR InterPro; IPR043172; Prp8_domainIV_palm.
DR InterPro; IPR019581; Prp8_U5-snRNA-bd.
DR InterPro; IPR042516; Prp8_U5-snRNA-bd_sf.
DR InterPro; IPR019580; Prp8_U6-snRNA-bd.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR019582; RRM_spliceosomal_PrP8.
DR PANTHER; PTHR11140; PRE-MRNA SPLICING FACTOR PRP8; 1.
DR PANTHER; PTHR11140:SF0; PRE-MRNA-PROCESSING-SPLICING FACTOR 8; 1.
DR Pfam; PF01398; JAB; 1.
DR Pfam; PF08082; PRO8NT; 1.
DR Pfam; PF08083; PROCN; 1.
DR Pfam; PF08084; PROCT; 1.
DR Pfam; PF12134; PRP8_domainIV; 1.
DR Pfam; PF10598; RRM_4; 1.
DR Pfam; PF10597; U5_2-snRNA_bdg; 1.
DR Pfam; PF10596; U6-snRNA_bdg; 1.
DR SMART; SM00232; JAB_MPN; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 2.
DR PROSITE; PS50249; MPN; 1.
PE 4: Predicted;
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000054815};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW Spliceosome {ECO:0000256|ARBA:ARBA00022728}.
FT DOMAIN 2089..2220
FT /note="MPN"
FT /evidence="ECO:0000259|PROSITE:PS50249"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KRX98336.1"
SQ SEQUENCE 2322 AA; 271653 MW; AA7C689C776D4ADF CRC64;
LRTMEVAPPG WNGPPPAMQN IPFAPGASVI SHPPLASSNQ FANAPRLTAE ELEDKAKKWQ
QLQSKRYAVK RKFGYTDTQK EEMPPEHVRK IIRDHGDMSS RKYRHDKRVY LGALKYMPHA
VLKLMENMPM PWEQMRDVKV LYHITGAITF VNEIPWVVEP VYIAQWGTMW IMMRREKRDR
RHFKRMRFPP FDDEEPPLDY ADNILDVEPL EPIQMELDPE EDETVFKWFY DNKPLVGTKY
VNGLTYKKWN FTLPMMATLY RLANQLLTDL VDDNYFYLFD LKTFFTAKAL NVAIPGGPKF
EPLVKDQNLQ DEDWNEFNDI NKIIIRQPIR TEYRIAFPYL YNNLINMLPV QLCWYHTPND
PELPAFYFDP LINPILLRHT SKTDPYFDDD EEDYKLPEGV EALFSDVPLY TDHTANGIAL
LWAPRPFNLR SGHTRRAIDI PLVKSWYREH CPSAMPVKVR VSYQKLLKIY VLNALKHRPP
KPQKRRYLFR SFKSTKFFQV TTLDWVEAGL QVCRQGYNML NLLIHRKNLN YLHLDYNFNL
KPVKTLTTKE RKKSRFGNAF HLCREILRLT KLVVDSHVQY RLNNIDAYQL ADGLQYIFAH
VGQLTGMYRY KYKLMRQIRM CKDLKHLIYY RFNTGTVGKG PGCGFWAPGW RVWLFFLRGV
TPLLERWLGN LLSRQFEGRH SKGVAKTVTK QRVESHYDLE LRAAVMHDII DMMPEGIKQN
KARTILQHLS EAWRCWKANI PWKVPGLPTP VENMILRFVK AKADWWTNTA HYNRERIRRG
ATVDKTVCKK NLGRLTRLYL KAEQERQHNY LKDGPYISPE EAVAVYTTTV HWLESRRFSP
IPFPPLSYKH DTKLLILALE RLKEAYSVKN RLNQSQREEL ALIEQAYDNP HEALSRIKRH
MLTQRAFKEV GIEFMDLYSH LVPVHDIEPL EKVTDAYLDQ YLWYEADKRR LFPQWIKPGD
SEPPPLLVYK WCQGINNLQD VWDTSNGECN VMLEAKFEKL YEKIDLTLLN RLLRLIVDHN
IADYMTAKNN VVINYKDMNH TNSYGIIRGL QFASFISQYY GLVLDLLLLG LRRASEIAGP
PQCPNDFLTF QDVATETAHP IRLYCRYVDR IWMFFKFTAD DAKDLIQRYL TEHPDPNNEN
IVGYNNKKCW PRDSRMRLMK HDNRLPRSLT TVEWENSFVS VYSRDNPNLL FDMAGFECRI
LPKCRMSHED FSHRDGVWNL QNEVTKERTA QCFLKVDEES MNRFHNRVRQ ILMASGSTTF
TKIVNKWNTA LIGLMTYYRE AVVNTQELLD LLVKCENKIQ TRIKIGLNSK MPARFPPVVF
YTPKELGGLG MLSMGHVLIP QSDLRWCKQT DAGGITHFRS GMSHDEDQLI PNLYRYIQPW
EAEFIDSQRV WAEYALKRQE ANAQNRRLTL EDLEDSWDRG IPRINTLFQK DRHTLAYDKG
WRVRTEFKQY QVLKQNPFWW THQRHDGKLW NLNNYRTDMI QALGGVEGIL EHTLFKGTYF
PTWEGLFWEK ASGFEESMKF KKLTNAQRSG LNQIPNRRFT LWWSPTINRA NVYVGFQVQL
DLTGIFMHGK IPTLKISLIQ IFRAHLWQKI HESIVMDLCQ VCDQELDALE IETVQKETIH
PRKSYKMNSS CADILLFAQY KWHVSRPSLL ADSKDIMDNT TTQKYWIDVQ LRWGDYDSHD
IERYSRAKFL DYTTDNMSIY PSPTGTLIAP LIRQAMAKIM KANPALYVLR ERIRKGLQLY
SSEPTEPYLT SQNYGELFSN QIIWFVDDTN VYRVTIHKTF EGNLTTKPIN GAIFIFNPRT
GQLFLKIIHT SVWAGQKRLG QLAKWKTAEE VAALIRSLPV EEQPRQIIVT RKAMLDPLEV
HLLDFPNIVI KGSELMLPFQ ACMKVEKFGD LILKATEPQM VLFNLYDDWL KTISSYTAFS
RLILMLRALH INPDKTKVIL KPDKTTITEA HHIWPSLADE EWIKVELALK DMILADYGKK
NNVNVASLTQ SEIRDIILGM EISAPSAQRQ QIAEIEKQTK EQSQLTATAT RTVNKHGDEI
ISTTTSNYES LSFASRTEWR VRAISATNLH LRTQHIYVNS DDVKDTGYTY ILPKNILKKF
IIISDLRTQI VGLLYGTSPT DNSQVKEIRC VVMPPQWGTH QTVHIPSVFP EHEFLKDLEP
LGWMHTQPNE LPQLSPQDIT LHAKLMNENQ NWDGEKTVVI TCSFTPGSVS LTAYKLTPSG
FEWGRQNTDK GNNPKGYLPS HYEKVQMLLS DRFLGFFMVP VQTSWNYNFM GVRHDANMKY
DVTLGNPKEF YHEQHRPSHF LNFVAIEDPE GIYSADRENL LA
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