ID A0A0V0YIJ8_TRIPS Unreviewed; 2925 AA.
AC A0A0V0YIJ8;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE SubName: Full=Metabotropic glutamate receptor 8 {ECO:0000313|EMBL:KRX99916.1};
DE Flags: Fragment;
GN Name=Grm4 {ECO:0000313|EMBL:KRX99916.1};
GN ORFNames=T4E_4172 {ECO:0000313|EMBL:KRX99916.1};
OS Trichinella pseudospiralis (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6337 {ECO:0000313|EMBL:KRX99916.1, ECO:0000313|Proteomes:UP000054815};
RN [1] {ECO:0000313|EMBL:KRX99916.1, ECO:0000313|Proteomes:UP000054815}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS141 {ECO:0000313|EMBL:KRX99916.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX99916.1}.
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DR EMBL; JYDU01000011; KRX99916.1; -; Genomic_DNA.
DR Proteomes; UP000054815; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR Gene3D; 3.40.50.2300; -; 10.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24060:SF176; MANGETOUT, ISOFORM G; 1.
DR PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 3.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 4.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:KRX99916.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054815};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..2925
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5006873274"
FT TRANSMEM 2606..2631
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2643..2663
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2669..2690
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2711..2731
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2793..2812
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2824..2842
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 2635..2809
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT NON_TER 2925
FT /evidence="ECO:0000313|EMBL:KRX99916.1"
SQ SEQUENCE 2925 AA; 331855 MW; 4057C72526E3652C CRC64;
MVNVNCSLII LFFTYGTVFG GNIALEQCAS EQLPAEKNAA AIITLILDVR RTLHNHDGPS
CGTVSEEGLQ IEEIAQWVIK ILNQASGTVF GLPVADSFIP GIELGLQVLD TCGIASRAIR
LSAEAFSDLQ SPKHKCTFND TRISLGVIVK ADDSTMHHLS DFFYQYKKSV IGLGSRSTML
KQKQVFTLQP DIDTIVQTIL KTAETMDWKH LWLIYENTDY GNEGKTLLTK MSTQQQSICI
LGTEQFSHGT NSSENIKLIL EKILSRKEDS YLIILFMSRS VALQFLQAAF EEELIVDSRR
MKWIMSDGFD ESFVDIFDLS KGVIAISDEN PYRIPEFLSH WTEADPKEHS KFWYKEFYQH
RHKCRLEDDT NPAFYRFGVC KNKKSAINHT DSELFLTPSA VHVVDAIFTY AIALKGAWMA
KCRGRPGLCP QLVQMDNQDF IRFMKHVEFS YRKENRSPPS LISRQVSHRK PKSQVAVFQV
QSDEQGNLLL KQIFRYDRFR NNRLLQLSAP LFYDNFGKID MEKKHSMTTN NKSNQCMTFQ
KRNTCHIIPG DLYIIAIIGI QEKGSYFDYC GQVNVEDSLA DVVFFNHALS SLNKKLLPDL
KIGSIIVDSC SNAIFAAQQI GTCLSNMEEI IFSEPDNDAS ISKQPLFIGA LIQADGLESA
EISHLLSLTL PSLPIVMYGK NVVPGIAPNI INFGTNFQNI ADAVFNVIQH FPCHYKQFIL
ARKYAPSVSV IESMAMKNLI GNFKILLTKF GSDFGGISSM NWIEKNANLS VVVLFLEEVE
LLEFLKIANQ SETSSNHIYL IVFDHIWTFE KLRNFSHLKD NMIIFYTDND ANYSLQDNII
NEAVDGIFNS KNIWIRQYIE SNLNCGKQNE KNEHNAIVAS CKNETILYLK KLALQHSIKT
NRLLASVDML VATLHHVVKN NCFDGFTTGN KCSQFLESFL NLKDNKMLNY VTKHYEKISE
NDMFVLPKKI GIYFQSQLKN EKFQQIGTFS FNSKKFEIID FSLFKNLSNQ ASSYCLNGSS
EKQHREQSAV QKSEELLTTL LPVTDMSNYL LQSENVKEMH IYPENIVMHI PPRSNGESVL
IGVLLPLMGS ANCEYLDYNK VKNEDAVYAL EALLWARKKV HILYNMDIQF IIFNTCSSVS
KTNILLNSFL INPQQFFGEK FGLNYTEDLL VGFINGYSAG SASIASEILS EASIINADIR
NNVQNRNSMT LHFSDNLNSY ISATLQFLDQ FQINFISILH SNDDTAVTFA DKFRLIANNY
NVCMAYISQV ESTQSLNTLI DNLKSVRNAG ATVVLVVLEF QKLIAFERAL EKQSHGLTFF
IILLQNEINA WNSNHFPVLL NSSILLKKQA DLPKDFMNHL LQLRYDNNDG NYLWSDFVKK
KFNCTTECHN RLPDISDYAM LNANQVLSAI NALSALAVGV RKLGSTMCKN QTIVCKELKE
LPNFGSKLLH ILQEEPFPAV DDISRKIRID ETRQVNEKLT ISTALILGSN ETPLLQPIAV
YEDEKLILNR IGIEVKNQSV FTSQCLDIHQ CKQCWKSMDK LLNSYLRKFS PALEVHTESS
DNVEEISSIP EEEAANVEKK TNKQIAESKS FVCIKSTSNI YLMAVIPIHN DGQKRLACGA
FSSNQYQRWK AIQWSLERLN YYLLAQTGIN LGIIAVDSCS NQAHTIKQLS YLINGDMQLD
SCIQGNLSDQ VIAAILVPYD QQDTSHEATV DLLTNNGILT FNWDSSFAYS ANSMLFSTGL
IEQSIVYGLV KFLAKTKWHY VAYIYSKNKN SMRRKHIFSN LANDNGICSE YILYPSHNKH
SCGEMTELFD QLKKIQVNGL RGVVLGLSMD KLRCFLDRME RLVASGQFSP NQFTFITALD
ANYKQAFFRY ESVAAGFVVV HPTAVELDEF HQYWKALKHL NVSNDIWWKE LLAADDWPER
QDEKLLYLAN AAYSVGHAIY ETKQQLCGSG MTASKKCNNL IMHHSFREAF RENVAKSKFV
DESGQMFIFD KDGLATQRVS ISLLVMDLDI VQWIEIGRIE NDVFDTKQRG NSPFQNYEPM
LYLKKLTSKC TNATLCPQCS RCSSLVQSLT CPSVHCKNEF EESTAPAQLD VTTEKIHLPA
PNLHYSESKL HWIVHSSNGI YAIALVPVHF PSEELFLCGP LDIFGGFRQA LAFMHSMEKL
NKQLPKQNQI GLIIIDTCNA KSDLAFSWIH QLSINNRSVQ ILAVLEAAYS NSNSNELAEL
MKNLQIPLLT IDPKLEMSKN EWNLQFKFDL NLYAEIACSV VHRLKFITPL VLFEQSNKLH
SSIMEKFIYC LESNNFNNAI TKIPVNNYRE LDAILNGLSN RPTAVFVLFM SSTFISAFKR
AIFQQPYNIG QTIVLGYGLE RIFTTTSPIK QAEQHSDVVT WLSIELLIEN EADISEFLLS
KQLNNHNPIP QYWFEEYWQQ MFTCRLSNSA IVENFHFHKN CTEKEEINST ALSKNVENDI
SVWFLMNVVV DGYKKYVDND CAQVSTAAQP TRLVNCLKNG NRINLLKYLK SSSWNQIAVG
NEFSNYKTLD NCKIVLKKIY MDKDQLLTES VALWKQTFTL SINGKLTSSS SSSKDILCKT
SVEDDCWKRF DFTVSNLEET NRMNEIWIVI AISLAGLGMT VCIITSIVLI VTDHASNDMF
NHLTLFGLFN LYAVTLAFTW QLSDIVCTIR LYATGFAWIL VFAPLSVKVV QMRLFPENGK
KQAYCWKKRN CIMVILALVF VHAIIVAQWM IVSKSTKIPV MFKHAKCAPV GSLATFELSL
TFSMAYPILI ILATMITAMT TTTDMSKHNK SSCGIAVTCM LTIIIWLFWN ITSTMEIFQL
SDPVIAMGIL INASVLFVGL RLRDNKNTST QSRRSYNVNM TRNEASLQPD LSLVPYGVNF
SKSKLGTFDS DQSYSTYSTV PKTKRYFNVM AYDGSSEFSA TTMVN
//
