ID   A0A0V0ZZH6_9BILA        Unreviewed;      1196 AA.
AC   A0A0V0ZZH6;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Guanine nucleotide exchange factor DBS {ECO:0000313|EMBL:KRY17562.1};
GN   Name=Mcf2l {ECO:0000313|EMBL:KRY17562.1};
GN   ORFNames=T12_2272 {ECO:0000313|EMBL:KRY17562.1};
OS   Trichinella patagoniensis.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=990121 {ECO:0000313|EMBL:KRY17562.1, ECO:0000313|Proteomes:UP000054783};
RN   [1] {ECO:0000313|EMBL:KRY17562.1, ECO:0000313|Proteomes:UP000054783}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS2496 {ECO:0000313|EMBL:KRY17562.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRY17562.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; JYDQ01000060; KRY17562.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0V0ZZH6; -.
DR   Proteomes; UP000054783; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.58.60; -; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR001251; CRAL-TRIO_dom.
DR   InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   PANTHER; PTHR22826:SF201; LD43457P; 1.
DR   PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR   Pfam; PF13716; CRAL_TRIO_2; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50191; CRAL_TRIO; 1.
DR   PROSITE; PS50010; DH_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000054783}.
FT   DOMAIN          129..281
FT                   /note="CRAL-TRIO"
FT                   /evidence="ECO:0000259|PROSITE:PS50191"
FT   DOMAIN          710..891
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   REGION          1106..1127
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1153..1178
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1109..1123
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1153..1171
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1196 AA;  136806 MW;  1FC2F72C6EC84280 CRC64;
     MNDNNGLAES KFSECFEIAK HESSKLKKQS IFSTHPTNQA CRMASVQLHS LQFNDVDKEQ
     AQQQQQPQQK ILRSDLEESG YQSALTRSQS SQYGTGWLYH DSESIASTSS CDDWDGYMKV
     DNQRVKIREV SDLLVTRYAF ISGAKTDQGF PVLTFPDSHV HLPFVEYRLL ITYLTRLQPY
     ELQVEDIFLG FVVIIDRRTD RWASVKTLLS HLSSFFPGNL RFVYVIKPDG VLQRALEVGY
     KHISGVNRLQ TFVCNSLPEL HQHINPSCLT YDLCGSFHYN HLEWLQHRME IERLRCSAEG
     IARTLDEFVQ NLRETELPND ASTTANILSS QKADRDAIKE DFRIIVRRGF DLLKSVRQAD
     TKPNAEQLSP TRVHNVTSVQ RTLLQLEDTE KRFDKFWPTH EFRLQHCLQL RQFEEDFKKL
     QSNFLCHLEK LRIGPHFETG ERDQCRLCSI DEVDRLIEEY RIYAEKTQAD VQAANSLKLR
     GEQLIAAEEK ELIGSLTPKC QELQRLTEQL DQALKNRSRF LHDVKKLHDY ICQANHWCNT
     GVQLMINMTM ELDDIRQCEE SLYSIQNLLS SSNDLTLDLD TSDSLLLLSA YDTKTLLSQV
     NARVSDVKQL CENRCVFLKR LLSKARISSF SEPIKMTAAK ATNPLSCTYR YLPLRDSSHT
     DIGQLSDDAS DDALAMLSPP PGSLWSELPY DQQANVDNNS CTFNAESSKR SSFVLNELLS
     TEQNYVDELR SVVKYYIHAF EDADQRRYVP NNLLSKQKVL FGNLHQIYNF HSEVFLPALK
     AAESNVRNIA RTFLDHTDHF QIYITYCLNK PLSEALLKQC PEGYSFLQMC QDRAGHALPL
     SAYLLKPVQR VTKYQLLLKE LARSVDRTEG SDQVEQALNA ILELLHLVNA SLNQGYIVGY
     TGDLSSLGAV LLEGRFRVWL NKKTGDKAPL RMRRASKVRQ RHVFLYSTVM LMCKCRRNSI
     PHIDECYEVK EELPIDMIEN VEVIKTTNNS SSTAQQEKFQ IITENKQEVL TFQSINTNIN
     AFQFVAKLKH LLSISDDSTG KKNGRMRRPI SWTSHSSNEA GYCNLDRKRH SESDLLVSDS
     NNNPSTCLGS ARSELNLLSS VGGTAAVADE ENNKTQNPAA KGTRNRDRWN VVSRTEYRTA
     TGSFPFLRSE LSAGEQANRQ ATNQPTIVSE RSERQQRTER LVECRASSLG YTASRF
//